Search Results - "TAKAHASHI, Sadao"

Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation by Takahashi, Sadao

“…Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL)…”
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The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins by Nakajima, Katsuyuki, Tokita, Yoshiharu, Tanaka, Akira, Takahashi, Sadao

“…A new concept to account for the process of postprandial remnant lipoprotein metabolism is proposed based on the characteristics of lipoprotein particles and…”
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Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice by Sato, Satsuki, Suzuki, Jinya, Hirose, Masamichi, Yamada, Mika, Zenimaru, Yasuo, Nakaya, Takahiro, Ichikawa, Mai, Imagawa, Michiko, Takahashi, Sadao, Ikuyama, Shoichiro, Konoshita, Tadashi, Kraemer, Fredric B, Ishizuka, Tamotsu

“…Atrial fibrillation (AF) is prevalent in patients with obesity and diabetes, and such patients often exhibit cardiac steatosis. Since the role of cardiac…”
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Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase by Ueno, Masami, Suzuki, Jinya, Hirose, Masamichi, Sato, Satsuki, Imagawa, Michiko, Zenimaru, Yasuo, Takahashi, Sadao, Ikuyama, Shoichiro, Koizumi, Tsutomu, Konoshita, Tadashi, Kraemer, Fredric B, Ishizuka, Tamotsu

“…Cardiac intracellular lipid accumulation (steatosis) is a pathophysiological phenomenon observed in starvation and diabetes mellitus. Perilipin 2 (PLIN2) is a…”
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Quantification of soluble very low-density lipoprotein receptor in human serum using a sandwich enzyme-linked immunosorbent assay by Tokita, Yoshiharu, Miyashita, Kazuya, Nakajima, Katsuyuki, Takahashi, Sadao, Tanaka, Akira

“…To investigate the regulation of soluble very low-density lipoprotein receptor (sVLDL-R), which is cleaved mostly from the extracellular domain of VLDL-R II,…”
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Role of VLDL receptor in atherogenesis by Takahashi, Sadao

“…My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the…”
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Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5) Is Essential for Normal Cholesterol Metabolism and Glucose-Induced Insulin Secretion by Fujino, Takahiro, Asaba, Hiroshi, Kang, Man-Jong, Ikeda, Yukio, Sone, Hideyuki, Takada, Shinji, Kim, Dong-Ho, Ioka, Ryoichi X., Ono, Masao, Tomoyori, Hiroko, Okubo, Minoru, Murase, Toshio, Kamataki, Akihisa, Yamamoto, Joji, Magoori, Kenta, Takahashi, Sadao, Miyamoto, Yoshiharu, Oishi, Hisashi, Nose, Masato, Okazaki, Mitsuyo, Usui, Shinichi, Imaizumi, Katsumi, Yanagisawa, Masashi, Sakai, Juro, Yamamoto, Tokuo T.

“…A Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) plays an essential role in bone accrual and eye development. Here, we show that LRP5…”
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Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice by Ueno, Masami, Suzuki, Jinya, Zenimaru, Yasuo, Takahashi, Sadao, Koizumi, Tsutomu, Noriki, Sakon, Yamaguchi, Osamu, Otsu, Kinya, Shen, Wen-Jun, Kraemer, Fredric B, Miyamori, Isamu

“…Intracellular lipid accumulation (steatosis) and resultant lipotoxicity are key features of diabetic cardiomyopathy. Since cardiac hormone-sensitive lipase…”
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The Very Low-density Lipoprotein (VLDL) Receptor: Characterization and Functions as a Peripheral Lipoprotein Receptor by Takahashi, Sadao, Sakai, Juro, Fujino, Takahiro, Hattori, Hiroaki, Zenimaru, Yasuo, Suzuki, Jinya, Miyamori, Isamu, Yamamoto, Tokuo T.

“…The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. In vitro and in vivo studies have shown that…”
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Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression by Takahashi, Sadao, Ito, Takashi, Zenimaru, Yasuo, Suzuki, Jinya, Miyamori, Isamu, Takahashi, Masao, Takahashi, Masafumi, Ishida, Takafumi, Ishida, Tatsuro, Hirata, Ken-ichi, Yamamoto, Tokuo T., Iwasaki, Tadao, Hattori, Hiroaki, Shiomi, Masashi

“…► We discovered species differences in macrophage VLDL-R protein. ► Human and rabbit macrophage VLDL-R protein were detected, no mouse macrophage VLDL-R…”
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New Therapeutic Target for Metabolic Syndrome: PPARδ by TAKAHASHI, Sadao, TANAKA, Toshiya, SAKAI, Juro

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Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: Effect of a high-dose statin on VLDL receptor expression by Imagawa, Michiko, Takahashi, Sadao, Zenimaru, Yasuo, Kimura, Tomoko, Suzuki, Jinya, Miyamori, Isamu, Iwasaki, Tadao, Hattori, Hiroaki, Yamamoto, Tokuo T., Nakano, Takamitsu, Nakajima, Katsuyuki

“…Comparison of the reactivity of remnant-like lipoprotein particles (RLP) and LDL particles to LDL receptor and VLDL receptor has not been investigated. LDL…”
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Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding by Suzuki, Jinya, Ueno, Masami, Uno, Miyuki, Hirose, Yoshikazu, Zenimaru, Yasuo, Takahashi, Sadao, Osuga, Jun-Ichi, Ishibashi, Shun, Takahashi, Masafumi, Hirose, Masamichi, Yamada, Mitsuhiko, Kraemer, Fredric B, Miyamori, Isamu

“…Increased fatty acid (FA) flux and intracellular lipid accumulation (steatosis) give rise to cardiac lipotoxicity in both pathological and physiological…”
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Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E by Magoori, Kenta, Kang, Man-Jong, Ito, Mitsuko R, Kakuuchi, Hajime, Ioka, Ryoichi X, Kamataki, Akihisa, Kim, Dong-Ho, Asaba, Hiroshi, Iwasaki, Satoshi, Takei, Yumiko A, Sasaki, Masako, Usui, Shinichi, Okazaki, Mitsuyo, Takahashi, Sadao, Ono, Masao, Nose, Masato, Sakai, Juro, Fujino, Takahiro, Yamamoto, Tokuo T

“…LDL receptor-related protein 5 (LRP5) plays multiple roles, including embryonic development and bone accrual development. Recently, we demonstrated that LRP5…”
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A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2 by Yamamoto, Joji, Ikeda, Yukio, Iguchi, Haruhisa, Fujino, Takahiro, Tanaka, Toshiya, Asaba, Hiroshi, Iwasaki, Satoshi, Ioka, Ryoichi X., Kaneko, Izumi W., Magoori, Kenta, Takahashi, Sadao, Mori, Toshiyuki, Sakaue, Hiroshi, Kodama, Tatsuhiko, Yanagisawa, Masashi, Yamamoto, Tokuo T., Ito, Sadayoshi, Sakai, Juro

“…Acetyl-CoA synthetase 2 (AceCS2) produces acetyl-CoA for oxidation through the citric acid cycle in the mitochondrial matrix. AceCS2 is highly expressed in the…”
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Familial lecithin-cholesterol acyltransferase (LCAT) deficiency by Takahashi, Sadao

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Expression Cloning and Characterization of a Novel Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein, GPI-HBP1 by Ioka, Ryoichi X, Kang, Man-Jong, Kamiyama, Shin, Kim, Dong-Ho, Magoori, Kenta, Kamataki, Akihisa, Ito, Yuichiro, Takei, Yumiko A, Sasaki, Masako, Suzuki, Takashi, Sasano, Hironobu, Takahashi, Sadao, Sakai, Juro, Fujino, Takahiro, Yamamoto, Tokuo T

“…By expression cloning using fluorescent-labeled high density lipoprotein (HDL), we isolated two clones that conferred the cell surface binding of HDL…”
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Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase (∗) by Takahashi, Sadao, Suzuki, Jinya, Kohno, Mitsuyuki, Oida, Koji, Tamai, Toshitaka, Miyabo, Susumu, Yamamoto, Tokuo, Nakai, Tsuguhiko

“…The low-density lipoprotein (LDL) receptor plays a crucial role in cholesterol metabolism. A related protein, designated the very low density lipoprotein…”
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Transcriptional Regulation of the Murine Acetyl-CoA Synthetase 1 Gene through Multiple Clustered Binding Sites for Sterol Regulatory Element-binding Proteins and a Single Neighboring Site for Sp1 by Ikeda, Yukio, Yamamoto, Joji, Okamura, Masashi, Fujino, Takahiro, Takahashi, Sadao, Takeuchi, Kazuhisa, Osborne, Timothy F., Yamamoto, Tokuo T., Ito, Sadayoshi, Sakai, Juro

“…Cytosolic acetyl-CoA synthetase (AceCS1) activates acetate to supply the cells with acetyl-CoA for lipid synthesis. The cDNA for the mammalian AceCS1 has been…”
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Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive by Oka, T, Kujiraoka, T, Ito, M, Egashira, T, Takahashi, S, Nanjee, M N, Miller, N E, Metso, J, Olkkonen, V M, Ehnholm, C, Jauhiainen, M, Hattori, H

“…Plasma phospholipid transfer protein (PLTP) plays an important role in the maintenance of plasma high-density lipoprotein (HDL) content and remodeling of HDL…”
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