Search Results - "TAKAHASHI, KOHTA"

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange by Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida‐Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M, Ikonen, Elina

“…Low‐density lipoprotein (LDL)‐cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the…”
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CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses by Maehara, Kayoko, Takahashi, Kohta, Saitoh, Shigeaki

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Biological and Pathological Roles of Ganglioside Sialidases by Miyagi, Taeko, Takahashi, Kohta, Yamamoto, Koji, Shiozaki, Kazuhiro, Yamaguchi, Kazunori

“…Sialidases are glycosidases responsible for the removal of α-glycosidically linked sialic acid residues from carbohydrate portions of glycoproteins and…”
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Regulation of Sialyl Lewis Antigen Expression in Colon Cancer Cells by Sialidase NEU4 by Shiozaki, Kazuhiro, Yamaguchi, Kazunori, Takahashi, Kohta, Moriya, Setsuko, Miyagi, Taeko

“…Sialyl Lewis antigens, sialyl Lewis a and sialyl Lewis x, are utilized as tumor markers, and their increase in cancer is associated with tumor progression by…”
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Electrochemical Fluorination Using Alkali-Metal Fluorides by Sawamura, Takahiro, Takahashi, Kohta, Inagi, Shinsuke, Fuchigami, Toshio

“…Charged up: The selective electrochemical fluorination of organic compounds using the alkali‐metal fluoride KF under very mild reaction conditions has been…”
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Epigenetic Inactivation and Subsequent Heterochromatinization of a Centromere Stabilize Dicentric Chromosomes by Sato, Hiroshi, Masuda, Fumie, Takayama, Yuko, Takahashi, Kohta, Saitoh, Shigeaki

“…The kinetochore is a multiprotein complex that forms on a chromosomal locus designated as the centromere, which links the chromosome to the spindle during…”
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Heterochromatin Integrity Affects Chromosome Reorganization After Centromere Dysfunction by Ishii, Kojiro, Ogiyama, Yuki, Chikashige, Yuji, Soejima, Saeko, Masuda, Fumie, Kakuma, Tatsuyuki, Hiraoka, Yasushi, Takahashi, Kohta

“…The centromere is essential for the inheritance of genetic information on eukaryotic chromosomes. Epigenetic regulation of centromere identity has been…”
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Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice by Sultana, Mst. Farzana, Suzuki, Maki, Yamasaki, Fumiya, Kubota, Wataru, Takahashi, Kohta, Abo, Hirohito, Kawashima, Hiroto

“…Angiogenin 4 bearing ribonuclease activity is an endogenous antimicrobial protein expressed in small and large intestine. However, the crucial amino acid…”
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Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum by Hata, Keiko, Tochigi, Tatsuo, Sato, Ikuro, Kawamura, Sadafumi, Shiozaki, Kazuhiro, Wada, Tadashi, Takahashi, Kohta, Moriya, Setsuko, Yamaguchi, Kazunori, Hosono, Masahiro, Miyagi, Taeko

“…Aberrant sialylation in glycoproteins and glycolipids is a characteristic feature of malignancy. Human sialidases, which catalyze the removal of sialic acid…”
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Mis16 and Mis18 Are Required for CENP-A Loading and Histone Deacetylation at Centromeres by Hayashi, Takeshi, Fujita, Yohta, Iwasaki, Osamu, Adachi, Yoh, Takahashi, Kohta, Yanagida, Mitsuhiro

“…Centromeres contain specialized chromatin that includes the centromere-specific histone H3 variant, spCENP-A/Cnp1. Here we report identification of five…”
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Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides by Pan, Xuefang, De Britto Pará De Aragão, Camila, Velasco‐Martin, Juan P., Priestman, David A., Wu, Harry Y., Takahashi, Kohta, Yamaguchi, Kazunori, Sturiale, Luisella, Garozzo, Domenico, Platt, Frances M., Lamarche‐Vane, Nathalie, Morales, Carlos R., Miyagi, Taeko, Pshezhetsky, Alexey V.

“…ABSTRACT Gangliosides (sialylated glycolipids) play an essential role in the CNS by regulating recognition and signaling in neurons. Metabolic blocks in…”
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Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling by Takahashi, Kohta, Hosono, Masahiro, Sato, Ikuro, Hata, Keiko, Wada, Tadashi, Yamaguchi, Kazunori, Nitta, Kazuo, Shima, Hiroshi, Miyagi, Taeko

“…The plasma membrane‐associated sialidase NEU3 is a key enzyme for ganglioside degradation. We previously demonstrated remarkable up‐regulation of NEU3 in…”
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Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins by Takahashi, Kohta, Proshin, Sergei, Yamaguchi, Kazunori, Yamashita, Yoji, Katakura, Ryuichi, Yamamoto, Koji, Shima, Hiroshi, Hosono, Masahiro, Miyagi, Taeko

“…Glioblastoma multiforme is one of the most malignant tumors of the human central nervous system characterized by high degree of invasiveness. Focusing on this…”
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Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis by Shiga, Kiyoto, Takahashi, Kohta, Sato, Ikuro, Kato, Kengo, Saijo, Shigeru, Moriya, Setsuko, Hosono, Masahiro, Miyagi, Taeko

“…Regional lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) is a crucial event for its progression, associated with a high rate of…”
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Biphasic incorporation of centromeric histone CENP-A in fission yeast by Takayama, Yuko, Sato, Hiroshi, Saitoh, Shigeaki, Ogiyama, Yuki, Masuda, Fumie, Takahashi, Kohta

“…CENP-A is a centromere-specific histone H3 variant that is essential for kinetochore formation. Here, we report that the fission yeast Schizosaccharomyces…”
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Differential regulation of repeated histone genes during the fission yeast cell cycle by Takayama, Yuko, Takahashi, Kohta

“…The histone genes are highly reiterated in a wide range of eukaryotic genomes. The fission yeast, Schizosaccharomyces pombe, has three pairs of histone H3-H4…”
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Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation by Yamamoto, Koji, Takahashi, Kohta, Shiozaki, Kazuhiro, Yamaguchi, Kazunori, Moriya, Setsuko, Hosono, Masahiro, Shima, Hiroshi, Miyagi, Taeko

“…We previously demonstrated that sialidase NEU3, a key glycosidase for ganglioside degradation, is up-regulated in various human cancers, leading to increased…”
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Total Synthesis of the Proposed Structure for Aromin and Its Structural Revision by Takahashi, Shunya, Satoh, Daisuke, Hayashi, Misato, Takahashi, Kohta, Yamaguchi, Kazunori, Nakamura, Takemichi, Koshino, Hiroyuki

“…This paper describes the first total synthesis of the proposed structure for aromin, an annonaceous acetogenin possessing an unusual bis-THF ring system, and…”
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Phosphatidic acid‐mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration by Shiozaki, Kazuhiro, Takahashi, Kohta, Hosono, Masahiro, Yamaguchi, Kazunori, Hata, Keiko, Shiozaki, Momo, Bassi, Rosaria, Prinetti, Alessandro, Sonnino, Sandro, Nitta, Kazuo, Miyagi, Taeko

“…ABSTRACT The plasma membrane‐associated sialidase NEU3 plays crucial roles in regulation of transmembrane signaling, and its aberrant up‐regulation in various…”
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N-acetylglucosamine-6-O-sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota by Abo, Hirohito, Muraki, Aoi, Harusato, Akihito, Imura, Tetsuya, Suzuki, Maki, Takahashi, Kohta, Denning, Timothy L, Kawashima, Hiroto

“…Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the…”
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