Search Results - "TAKAGI, Kazutaka"

Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance by ANTONY, Smitha, AGAMA, Keli K, POMMIER, Yves, MIAO, Ze-Hong, TAKAGI, Kazutaka, WRIGHT, Mollie H, ROBLES, Ana I, VARTICOVSKI, Lyuba, NAGARAJAN, Muthukaman, MORRELL, Andrew, CUSHMAN, Mark

“…Camptothecin (CPT) derivatives are effective anticancer drugs, especially against solid tumors. As CPTs are chemically unstable and have clinical limitations,…”
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Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5′-nucleotidase II expression ratio in primary acute myeloid leukemia cells by Yamauchi, Takahiro, Negoro, Eiju, Kishi, Shinji, Takagi, Kazutaka, Yoshida, Akira, Urasaki, Yoshimasa, Iwasaki, Hiromichi, Ueda, Takanori

“…Cytarabine (ara-C) is the key agent for treating acute myeloid leukemia (AML). After being transported into leukemic cells by human equilibrative nucleoside…”
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Development of acute lymphoblastic leukemia with IgH-EPOR in a patient with secondary erythrocytosis by Sakamoto, Kenichi, Tanaka, Seiji, Tomoyasu, Chihiro, Tomii, Toshihiro, Yano, Mio, Takagi, Kazutaka, Yasuhiko, Tsutsumi, Uoshima, Nobuhiko, Komatsu, Hiroshi, Imamura, Toshihiko

“…We report the first patient to develop ALL with a fusion gene of the erythropoietin receptor (EPOR) with immunoglobulin heavy chain (IgH) 22 years after a…”
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Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells by Yamauchi, Takahiro, Matsuda, Yasufumi, Tasaki, Toshiki, Negoro, Eiju, Ikegaya, Satoshi, Takagi, Kazutaka, Yoshida, Akira, Urasaki, Yoshimasa, Ueda, Takanori

“…Gemtuzumab ozogamicin (GO) consists of the CD33 antibody linked to calicheamicin. The binding of GO to the CD33 antigen on leukemic cells results in…”
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Von Hippel-Lindau–Coupled and Transcription-Coupled Nucleotide Excision Repair–Dependent Degradation of RNA Polymerase II in Response to Trabectedin by Aune, Gregory J, Takagi, Kazutaka, Sordet, Olivier, Guirouilh-Barbat, Josée, Antony, Smitha, Bohr, Vilhelm A, Pommier, Yves

“…Purpose: Ecteinascidin 743 (Et743; trabectedin, Yondelis) has recently been approved in Europe for the treatment of soft tissue sarcomas and is undergoing…”
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Marked upregulation of Survivin and Aurora-B kinase is associated with disease progression in the myelodysplastic syndromes by YOSHIDA, Akira, ZOKUMASU, Kouichi, WANO, Yuji, YAMAUCHI, Takahiro, IMAMURA, Shin, TAKAGI, Kazutaka, KISHI, Shinji, URASAKI, Yoshimasa, TOHYAMA, Kaoru, UEDA, Takanori

“…Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Survivin is a…”
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Synergistic effects of combination with fludarabine and carboplatin depend on fludarabine-mediated inhibition of enhanced nucleotide excision repair in leukemia by Takagi, Kazutaka, Kawai, Yasukazu, Yamauchi, Takahiro, Iwasaki, Hiromichi, Ueda, Takanori

“…Overcoming drug resistance remains a major obstacle to curing relapsed or refractory lymphoma and obtaining a beneficial long-term prognosis for patients,…”
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Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters by Takagi, Kazutaka, Dexheimer, Thomas S, Redon, Christophe, Sordet, Olivier, Agama, Keli, Lavielle, Gilbert, Pierré, Alain, Bates, Susan E, Pommier, Yves

“…Camptothecin (CPT) analogues are powerful anticancer agents but are chemically unstable due to their α-hydroxylactone six-membered E-ring structure, which is…”
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Multiple inflammatory cytokine‐productive ThyL‐6 cell line established from a patient with thymic carcinoma by Inai, Kunihiro, Takagi, Kazutaka, Takimoto, Nobuo, Okada, Hiromi, Imamura, Yoshiaki, Ueda, Takanori, Naiki, Hironobu, Noriki, Sakon

“…Thymic epithelial cells can produce many kinds of cytokines, and interleukin (IL)‐6‐producing thymic carcinoma cases have been reported. However, a…”
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Variation of Urate Transport in the Nephrons in Subtypes of Hyperuricemia by Nakamura, Toru, Nishi, Rie, Tanaka, Tuneo, Takagi, Kazutaka, Sakai, Katsuya, Takai, Mihoko, Morishima, Shigeru, Yamauchi, Takahiro, Ueda, Takanori

“…Background: Hyperuricemia cases (HU) can be classified into four subgroups by combining the two main causes of hyperuricemia, i.e. urate underexcretion and…”
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Quantitative Estimation of Urate Transport in Nephrons in Relation to Urinary Excretion Employing Benzbromarone-Loading Urate Clearance Tests in Cases of Hyperuricemia by Nakamura, Toru, Nishi, Rie, Tanaka, Tuneo, Takagi, Kazutaka, Yamashita, Taro, Yamauchi, Takahiro, Ueda, Takanori

“…Background: A four-component system for urate transport in nephrons has been proposed and widely investigated by various investigators studying the mechanisms…”
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Successful Administration of Recombinant Human Soluble Thrombomodulin α (Recomodulin) for Disseminated Intravascular Coagulation during Induction Chemotherapy in an Elderly Patient with Acute Monoblastic Leukemia Involving the t(9;11)(p22;q23) MLL/AF9 Translocation by Iwasaki, Hiromichi, Tasaki, Toshiki, Yamauchi, Takahiro, Ueda, Takanori, Takagi, Kazutaka

“…Patients with acute myelogenous leukemia complicate with disseminated intravascular coagulation (DIC), not only at the time of the initially leukemia…”
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53% PAE 32W Miniaturized X-Band GaN HEMT Power Amplifier MMICs by Ono, Naoko, Senju, Tomohiro, Takagi, Kazutaka

“…We have developed a miniaturized high efficiency X-band power amplifier MMIC with \pmb{0.25} \ \pmb{\mu}\ \mathbf{m} \ \mathbf{AlGaN}\mathbf{/GaN} HEMT on SiC…”
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Combined Low-dose Cytarabine, Melphalan and Mitoxantone for Older Patients with Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome by YAMAUCHI, Takahiro, NEGORO, Eiju, UEDA, Takanori, ARAI, Hajime, IKEGAYA, Satoshi, TAKAGI, Kazutaka, TAKEMURA, Haruyuki, INAI, Kunihiro, YOSHIDA, Akira, URASAKI, Yoshimasa, IWASAKI, Hiromichi

“…Background: Low-dose cytarabine (ara-C) has been used to treat older patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS),…”
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Physiology and dynamics of uric acid in hyperuricemia by Takagi, Kazutaka, Nakamura, Toru, Ueda, Takanori

“…Gout is a type of inflammatory arthritis that is triggered by the crystallization of monosodium urate (MSU) within the joints and is often associated with…”
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Typing of hypouricemia (uric acid clearance) by Tsutani, Hiroshi, Takagi, Kazutaka

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A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease by Masaki, Yasufumi, Matsui, Shoko, Saeki, Takako, Tsuboi, Hiroto, Hirata, Shintaro, Izumi, Yasumori, Miyashita, Taiichiro, Fujikawa, Keita, Dobashi, Hiroaki, Susaki, Kentaro, Morimoto, Hisanori, Takagi, Kazutaka, Kawano, Mitsuhiro, Origuchi, Tomoki, Wada, Yoko, Takahashi, Naoki, Horikoshi, Masanobu, Ogishima, Hiroshi, Suzuki, Yasunori, Kawanami, Takafumi, Kawanami Iwao, Haruka, Sakai, Tomoyuki, Fujita, Yoshimasa, Fukushima, Toshihiro, Saito, Masatoshi, Suzuki, Ritsuro, Morikawa, Yuko, Yoshino, Tadashi, Nakamura, Shigeo, Kojima, Masaru, Kurose, Nozomu, Sato, Yasuharu, Tanaka, Yoshiya, Sugai, Susumu, Sumida, Takayuki

“…Objective: Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, the treatment…”
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An X-band 250W solid-state power amplifier using GaN power HEMTs by Kanto, K., Satomi, A., Asahi, Y., Kashiwabara, Y., Matsushita, K., Takagi, K.

“…More than 250 W of peak output power (pulse width 64 mus, duty cycle 7%) is achieved with newly developed X-band solid-state power amplifier. The final stage…”
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A high serum uric acid level is associated with poor prognosis in patients with acute myeloid leukemia by Yamauchi, Takahiro, Negoro, Eiju, Lee, Shin, Takai, Mihoko, Matsuda, Yasufumi, Takagi, Kazutaka, Kishi, Shinji, Tai, Katsunori, Hosono, Naoko, Tasaki, Toshiki, Ikegaya, Satoshi, Inai, Kunihiro, Yoshida, Akira, Urasaki, Yoshimasa, Iwasaki, Hiromichi, Ueda, Takanori

“…Uric acid in serum (S-UA) is produced by the breakdown of the cellular nucleic acids of leukemia cells, and may be a marker of disease aggressiveness. S-UA…”
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Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes by Yoshida, Akira, Zokumasu, Kouichi, Yamauchi, Takahiro, Takagi, Kazutaka, Kishi, Shinji, Urasaki, Yoshimasa, Tohyama, Kaoru, Ueda, Takanori

“…Abstract 3823 Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffctive hematopoiesis…”
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