Search Results - "TAIT, G"

Mitochondria as multifaceted regulators of cell death by Bock, Florian J., Tait, Stephen W. G.

“…Through their many and varied metabolic functions, mitochondria power life. Paradoxically, mitochondria also have a central role in apoptotic cell death. Upon…”
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A fate worse than death: apoptosis as an oncogenic process by Ichim, Gabriel, Tait, Stephen W. G.

“…Apoptotic cell death undoubtedly has beneficial roles in cancer, but paradoxically, apoptosis can also cause unwanted effects that could promote cancer. This…”
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Targeting BCL-2 regulated apoptosis in cancer by Campbell, Kirsteen J., Tait, Stephen W. G.

“…The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro-…”
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Mitochondrial apoptosis: killing cancer using the enemy within by Lopez, J, Tait, S W G

“…Apoptotic cell death inhibits oncogenesis at multiple stages, ranging from transformation to metastasis. Consequently, in order for cancer to develop and…”
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Reliability of the American Society of Anesthesiologists physical status scale in clinical practice by Sankar, A., Johnson, S.R., Beattie, W.S., Tait, G., Wijeysundera, D.N.

“…Previous studies, which relied on hypothetical cases and chart reviews, have questioned the inter-rater reliability of the ASA physical status (ASA-PS) scale…”
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Mitochondria and cell death: outer membrane permeabilization and beyond by Green, Douglas R, Tait, Stephen W. G

“…Key Points Mitochondrial outer membrane permeabilization (MOMP) is a crucial event for most apoptotic pathways. MOMP leads to the release of mitochondrial…”
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Die another way--non-apoptotic mechanisms of cell death by Tait, Stephen W G, Ichim, Gabriel, Green, Douglas R

“…Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during…”
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RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis by Orozco, S, Yatim, N, Werner, M R, Tran, H, Gunja, S Y, Tait, S WG, Albert, M L, Green, D R, Oberst, A

“…Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Mitochondria and Inflammation: Cell Death Heats Up by Vringer, Esmee, Tait, Stephen W G

“…Mitochondrial outer membrane permeabilization (MOMP) is essential to initiate mitochondrial apoptosis. Due to the disruption of mitochondrial outer membrane…”
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Genomic mating as sustainable breeding for Chinese indigenous Ningxiang pigs by He, Jun, Wu, Xiao-Lin, Zeng, Qinghua, Li, Hao, Ma, Haiming, Jiang, Juan, Rosa, Guilherme J. M, Gianola, Daniel, Tait Jr., Richard G, Bauck, Stewart

“…An important economic reason for the loss of local breeds is that they tend to be less productive, and hence having less market value than commercial breeds…”
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Modulating mitofusins to control mitochondrial function and signaling by Zacharioudakis, Emmanouil, Agianian, Bogos, Kumar MV, Vasantha, Biris, Nikolaos, Garner, Thomas P., Rabinovich-Nikitin, Inna, Ouchida, Amanda T., Margulets, Victoria, Nordstrøm, Lars Ulrik, Riley, Joel S., Dolgalev, Igor, Chen, Yun, Wittig, Andre J. H., Pekson, Ryan, Mathew, Chris, Wei, Peter, Tsirigos, Aristotelis, Tait, Stephen W. G., Kirshenbaum, Lorrie A., Kitsis, Richard N., Gavathiotis, Evripidis

“…Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a physiological process that impacts diverse cellular processes…”
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Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death by Bock, Florian J., Sedov, Egor, Koren, Elle, Koessinger, Anna L., Cloix, Catherine, Zerbst, Désirée, Athineos, Dimitris, Anand, Jayanthi, Campbell, Kirsteen J., Blyth, Karen, Fuchs, Yaron, Tait, Stephen W. G.

“…Damaged or superfluous cells are typically eliminated by apoptosis. Although apoptosis is a cell-autonomous process, apoptotic cells communicate with their…”
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Per- and polyfluoroalkyl substances (PFAS) in river discharge: Modeling loads upstream and downstream of a PFAS manufacturing plant in the Cape Fear watershed, North Carolina by Pétré, M.-A., Salk, K.R., Stapleton, H.M., Ferguson, P.L., Tait, G., Obenour, D.R., Knappe, D.R.U., Genereux, D.P.

“…The Cape Fear River is an important source of drinking water in North Carolina, and many drinking water intakes in the watershed are affected by per- and…”
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Spray coated high-conductivity PEDOT:PSS transparent electrodes for stretchable and mechanically-robust organic solar cells by Tait, Jeffrey G., Worfolk, Brian J., Maloney, Samuel A., Hauger, Tate C., Elias, Anastasia L., Buriak, Jillian M., Harris, Kenneth D.

“…High conductivity poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) was spray cast to form highly flexible transparent electrodes for…”
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MCL-1 is a prognostic indicator and drug target in breast cancer by Campbell, Kirsteen J., Dhayade, Sandeep, Ferrari, Nicola, Sims, Andrew H., Johnson, Emma, Mason, Susan M., Dickson, Ashley, Ryan, Kevin M., Kalna, Gabriela, Edwards, Joanne, Tait, Stephen W. G., Blyth, Karen

“…Analysis of publicly available genomic and gene expression data demonstrates that MCL1 expression is frequently elevated in breast cancer. Distinct from other…”
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Getting more bang for their buck: BCL2 inhibitors boost dendritic-cell function to enhance anti-cancer immune surveillance by Montes-Gómez, Alfredo E, Tait, Stephen W G

“…The anti-apoptotic BCL-2 protein family regulates cancer cell survival, thus it represents an important therapeutic target. Indeed, a drug class, called…”
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Retrograde signaling from autophagy modulates stress responses by Simon, Hans-Uwe, Friis, Robert, Tait, Stephen W G, Ryan, Kevin M

“…Macroautophagy is a process in which cytoplasmic components, including whole organelles, are degraded within lysosomes. Basally, this process is essential for…”
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Association between preoperative ambulatory heart rate and postoperative myocardial injury: a retrospective cohort study by Ladha, K S, Beattie, W S, Tait, G, Wijeysundera, D N

“…Resting heart rate is well established as a predictor of morbidity and mortality in the general population. However, the relationship between preoperative…”
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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness by Fanfone, Deborah, Wu, Zhichong, Mammi, Jade, Berthenet, Kevin, Neves, David, Weber, Kathrin, Halaburkova, Andrea, Virard, François, Bunel, Félix, Jamard, Catherine, Hernandez-Vargas, Hector, Tait, Stephen W G, Hennino, Ana, Ichim, Gabriel

“…Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are…”
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