Search Results - "TAFFURELLI, Mario"

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis by Chang, Qing, Bournazou, Eirini, Sansone, Pasquale, Berishaj, Marjan, Gao, Sizhi Paul, Daly, Laura, Wels, Jared, Theilen, Till, Granitto, Selena, Zhang, Xinmin, Cotari, Jesse, Alpaugh, Mary L, de Stanchina, Elisa, Manova, Katia, Li, Ming, Bonafe, Massimiliano, Ceccarelli, Claudio, Taffurelli, Mario, Santini, Donatella, Altan-Bonnet, Gregoire, Kaplan, Rosandra, Norton, Larry, Nishimoto, Norihiro, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline

“…Abstract We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and metastasis. In human primary breast cancers, increased…”
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Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer by Sansone, Pasquale, Ceccarelli, Claudio, Berishaj, Marjan, Chang, Qing, Rajasekhar, Vinagolu K., Perna, Fabiana, Bowman, Robert L., Vidone, Michele, Daly, Laura, Nnoli, Jennifer, Santini, Donatella, Taffurelli, Mario, Shih, Natalie N. C., Feldman, Michael, Mao, Jun J., Colameco , Christopher, Chen, Jinbo, DeMichele, Angela, Fabbri, Nicola, Healey, John H., Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline

“…The mechanisms of metastatic progression from hormonal therapy (HT) are largely unknown in luminal breast cancer. Here we demonstrate the enrichment of CD133…”
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Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence by Zacchini, Federico, Venturi, Giulia, De Sanctis, Veronica, Bertorelli, Roberto, Ceccarelli, Claudio, Santini, Donatella, Taffurelli, Mario, Penzo, Marianna, Treré, Davide, Inga, Alberto, Dassi, Erik, Montanaro, Lorenzo

“…Abstract Background Dyskerin is a nuclear protein involved in H/ACA box snoRNA-guided uridine modification of RNA. In humans, its defective function is…”
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A simple immunohistochemical bio-profile incorporating Bcl2 curbs those cases of invasive breast carcinoma for which an Oncotype Dx characterization is needed by Ceccarelli, Claudio, De Leo, Antonio, Chieco, Pasquale, Zamagni, Claudio, Zamagni, Alice, Rubino, Daniela, Taffurelli, Mario, Santini, Donatella

“…Our goal has been to evaluate the importance that the incorporation of Bcl2 in the ER/PGR/Her2/Ki67 bio-profile can have as predictor of the Oncotype Dx…”
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Mitochondrial DNA analysis efficiently contributes to the identification of metastatic contralateral breast cancers by Girolimetti, Giulia, Marchio, Lorena, De Leo, Antonio, Mangiarelli, Miriam, Amato, Laura Benedetta, Zanotti, Simone, Taffurelli, Mario, Santini, Donatella, Gasparre, Giuseppe, Ceccarelli, Claudio

“…Purpose In daily practice, a contralateral breast cancer (CBC) is usually considered as a new independent tumor despite the indications of several studies…”
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Liquid Biopsy in the Management of Breast Cancer Patients: Where Are We Now and Where Are We Going by Mazzitelli, Carlotta, Santini, Donatella, Corradini, Angelo Gianluca, Zamagni, Claudio, Trerè, Davide, Montanaro, Lorenzo, Taffurelli, Mario

“…Liquid biopsy (LB) is an emerging diagnostic tool that analyzes biomarkers in the blood (and possibly in other body fluids) to provide information about tumor…”
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HPV DNA Associates With Breast Cancer Malignancy and It Is Transferred to Breast Cancer Stromal Cells by Extracellular Vesicles by De Carolis, Sabrina, Storci, Gianluca, Ceccarelli, Claudio, Savini, Claudia, Gallucci, Lara, Sansone, Pasquale, Santini, Donatella, Seracchioli, Renato, Taffurelli, Mario, Fabbri, Francesco, Romani, Fabrizio, Compagnone, Gaetano, Giuliani, Cristina, Garagnani, Paolo, Bonafè, Massimiliano, Cricca, Monica

“…A causal link between Human Papillomavirus (HPV) and breast cancer (BC) remains controversial. In spite of this, the observation that HPV DNA is…”
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Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation by MONTANARO, Lorenzo, CALIENNI, Maria, BRIGOTTI, Maurizio, BONAFE, Massimiliano, TRERE, Davide, DERENZINI, Massimo, BERTONI, Sara, ROCCHI, Laura, SANSONE, Pasquale, STORCI, Gianluca, SANTINI, Donatella, CECCARELLI, Claudio, TAFFURELLI, Mario, CARNICELLI, Domenica

“…In up to 60% of human cancers, p53 gene mutations are responsible for direct inactivation of the tumor suppressor function of p53. Alternative mechanisms of…”
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p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres by Sansone, Pasquale, Storci, Gianluca, Giovannini, Catia, Pandolfi, Silvia, Pianetti, Simona, Taffurelli, Mario, Santini, Donatella, Ceccarelli, Claudio, Chieco, Pasquale, Bonafé, Massimiliano

“…The comprehension of the basic biology of stem cells is expected to provide a useful insight into the pathogenesis of cancer. In particular, there is evidence…”
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Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft by Landuzzi, Lorena, Palladini, Arianna, Ceccarelli, Claudio, Asioli, Sofia, Nicoletti, Giordano, Giusti, Veronica, Ruzzi, Francesca, Ianzano, Marianna L., Scalambra, Laura, Laranga, Roberta, Balboni, Tania, Arigoni, Maddalena, Olivero, Martina, Calogero, Raffaele A., De Giovanni, Carla, Dall’Ora, Massimiliano, Di Oto, Enrico, Santini, Donatella, Foschini, Maria Pia, Cucchi, Maria Cristina, Zanotti, Simone, Taffurelli, Mario, Nanni, Patrizia, Lollini, Pier-Luigi

“…We established patient-derived xenografts (PDX) from human primary breast cancers and studied whether stability or progressive events occurred during long-term…”
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Nipple discharge: is its significance as a risk factor for breast cancer fully understood? Observational study including 915 consecutive patients who underwent selective duct excision by Montroni, Isacco, Santini, Donatella, Zucchini, Giorgia, Fiacchi, Monica, Zanotti, Simone, Ugolini, Giampaolo, Manaresi, Alessio, Taffurelli, Mario

“…Nipple discharge (ND) is a common symptom seen in breast cancer clinics. The primary aim of this study was to identify preoperative risk factors for breast…”
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Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells by Papi, Alessio, Storci, Gianluca, Guarnieri, Tiziana, De Carolis, Sabrina, Bertoni, Sara, Avenia, Nicola, Sanguinetti, Alessandro, Sidoni, Angelo, Santini, Donatella, Ceccarelli, Claudio, Taffurelli, Mario, Orlandi, Marina, Bonafé, Massimiliano

“…Cancer stem cell biology is tightly connected to the regulation of the pro-inflammatory cytokine network. The concept of cancer stem cells "inflammatory…”
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Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia by D'Uva, Gabriele, Bertoni, Sara, Lauriola, Mattia, De Carolis, Sabrina, Pacilli, Annalisa, D'Anello, Laura, Santini, Donatella, Taffurelli, Mario, Ceccarelli, Claudio, Yarden, Yosef, Montanaro, Lorenzo, Bonafé, Massimiliano, Storci, Gianluca

“…Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms…”
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Granular cell tumour of the breast: A rare presentation of a breast mass in an elderly female with a subsequent breast cancer diagnosis by Al-Balas, Mahmoud, De Leo, Antonio, Serra, Margherita, Santini, Donatella, Taffurelli, Mario

“…A 74-year-old female patient presented with a hard breast mass and dimpling with a clinical suspicion of a carcinoma. Histological evaluation revealed a…”
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COVID-19-free Surgical Pathways for Breast Cancer Patients by Grendele, Sara, Pellegrini, Alice, Bardelli, Matteo, Cisternino, Giovanni, Melina, Marica, Serra, Margherita, Taffurelli, Mario, Zanotti, Simone

“…NA…”
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A regional population‐based hereditary breast cancer screening tool in Italy: First 5‐year results by Cortesi, Laura, Baldassarri, Bruna, Ferretti, Stefano, Razzaboni, Elisabetta, Bella, Mariangela, Bucchi, Lauro, Canuti, Debora, De Iaco, Pierandrea, De Santis, Giorgio, Falcini, Fabio, Galli, Vania, Godino, Lea, Leoni, Maurizio, Perrone, Anna Myriam, Pignatti, Marco, Saguatti, Gianni, Santini, Donatella, Sassoli de'Bianchi, Priscilla, Sebastiani, Federica, Taffurelli, Mario, Tazzioli, Giovanni, Turchetti, Daniela, Zamagni, Claudio, Naldoni, Carlo

“…Background Up to 10% of individuals with breast cancer (BC) belong to families with hereditary syndromes. The aim of this study was to develop an instrument to…”
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A Prospective, Double-Blind, Multicenter, Randomized Trial Comparing Ertapenem 3 Vs ≥5 Days in Community-Acquired Intraabdominal Infection by Basoli, Antonio, Chirletti, Piero, Cirino, Ercole, D’Ovidio, Nicola G., Doglietto, Giovanni Battista, Giglio, Domenico, Giulini, Stefano M., Malizia, Alberto, Taffurelli, Mario, Petrovic, Jelena, Ecari, Maurizio

“…Severe secondary peritonitis is diagnosed in only 20–30% of all patients, but studies to date have persisted in using a standard fixed duration of antibiotic…”
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Loss of Retinoblastoma Tumor Suppressor Protein Makes Human Breast Cancer Cells More Sensitive to Antimetabolite Exposure by DERENZINI, Massimo, DONATI, Giulio, MAZZINI, Giuliano, MONTANARO, Lorenzo, VICI, Manuela, CECCARELLI, Claudio, SANTINI, Donatella, TAFFURELLI, Mario, TRERE, Davide

“…Purpose: The RB tumor-suppressor activity may influence the therapeutic response in human breast cancers. The effect of adjuvant therapy on clinical outcome of…”
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The Challenge of Education in Colorectal Cancer Surgery: A Comparison of Early Oncological Results, Morbidity, and Mortality Between Residents and Attending Surgeons Performing an Open Right Colectomy by Montroni, Isacco, MD, Ghignone, Federico, MD, Rosati, Giancarlo, PhD, Zattoni, Davide, MD, Manaresi, Alessio, MD, Taffurelli, Mario, MD, Ugolini, Giampaolo, PhD

“…Objectives Ongoing education in surgical oncology is mandatory in a modern residency program. Achieving acceptable morbidity and mortality rates, together with…”
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Retention of the p53 Codon 72 Arginine Allele Is Associated with a Reduction of Disease-Free and Overall Survival in Arginine/Proline Heterozygous Breast Cancer Patients by BONAFE, Massimiliano, CECCARELLI, Claudio, FRANCESCHI, Claudio, FARABEGOLI, Fulvia, SANTINI, Donatella, TAFFURELLI, Mario, BARBI, Cristiana, MARZI, Erika, TRAPASSI, Chiara, STORCI, Gianluca, OLIVIERI, Fabiola

“…Purpose: The arginine to proline substitution at codon 72 represents a common aminoacidic polymorphism of the p53 protein. Recent data suggest that p53 codon…”
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