Search Results - "TADESSE, Seifu"

Do Gender-Based Pathways Influence Mental Health? Examining the Linkages Between Early Child Marriage, Intimate Partner Violence, and Psychological Well-being among Young Ethiopian Women (18–24 years Old) by John, Neetu A., Kapungu, Chisina, Sebany, Meroji, Tadesse, Seifu

“…Limited emphasis is placed on understanding the gendered pathways that influence mental health, especially long-term cumulative impacts of gender-based…”
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Cash plus programming and intimate partner violence: a qualitative evaluation of the benefits of group-based platforms for delivering activities in support of the Ethiopian government’s Productive Safety Net Programme (PSNP) by Buller, Ana Maria, Pichon, Marjorie, Hidrobo, Melissa, Mulford, Michael, Amare, Tseday, Sintayehu, Wastina, Tadesse, Seifu, Ranganathan, Meghna

“…ObjectivesIntimate partner violence (IPV) is a public health challenge but there is evidence that cash and cash ‘plus’ interventions reduce IPV. An…”
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Azole-based inhibitors of AKT/PKB for the treatment of cancer by Zeng, Qingping, Allen, John G., Bourbeau, Matthew P., Wang, Xianghong, Yao, Guomin, Tadesse, Seifu, Rider, James T., Yuan, Chester C., Hong, Fang-Tsao, Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie A., Freeman, Daniel J., Yang, Suijin, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey K., Fotsch, Christopher, Dominguez, Celia, Hungate, Randall, Zhang, Xiaoling

“…Through a combination of screening and structure-based rational design, we have discovered a series of N…”
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase by HAQUE, Tasir S., TADESSE, Seifu, MARCINKEVICIENE, Jovita, ROGERS, M. John, SIZEMORE, Christine, KOPCHO, Lisa M., AMSLER, Karen, ECRET, Lisa D., ZHAN, Dong Liang, HOBBS, Frank, SLEE, Andrew, TRAINOR, George L., STERN, Andrew M., COPELAND, Robert A., COMBS, Andrew P.

“…The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach…”
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Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis by Copeland, Robert A., Marcinkeviciene, Jovita, Haque, Tasir S., Kopcho, Lisa M., Jiang, Wenjun, Wang, Kathy, Ecret, Lisa D., Sizemore, Christine, Amsler, Karen A., Foster, Lori, Tadesse, Seifu, Combs, Andrew P., Stern, Andrew M., Trainor, George L., Slee, Andrew, Rogers, M. John, Hobbs, Frank

“…We report the discovery of a class of pyrazole-based compounds that are potent inhibitors of the dihydroorotate dehydrogenase of Helicobacter pylori but that…”
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Government of Ethiopia's public works and complementary programmes: A mixed-methods study on pathways to reduce intimate partner violence by Ranganathan, Meghna, Pichon, Marjorie, Hidrobo, Melissa, Tambet, Heleene, Sintayehu, Wastina, Tadesse, Seifu, Buller, Ana Maria

“…There is evidence that cash transfers reduce intimate partner violence (IPV), but less is known about the impacts of public works and complementary programmes…”
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Household Decision-Making: Implications for Production, Consumption, and Sale of Nutrient-Rich Foods by Tadesse, Seifu, Kershaw, Meghan, Knapp, Rachel, Gizaw, Rahel, Biadgilign, Sibhatu, Feleke, Amare, Dessalegn, Yigzaw, Abuye, Cherinet, Kennedy, Eileen

“…Household decision-making influences choices related to the production, sale, purchase, and consumption of nutrient-rich foods. The present study assessed the…”
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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint by Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J

“…The HTS-based discovery and structure-guided optimization of a novel series of GKRP-selective GK–GKRP disrupters are revealed. Diarylmethane­sulfonamide hit 6…”
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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis by Tamayo, Nuria A, Norman, Mark H, Bartberger, Michael D, Hong, Fang-Tsao, Bo, Yunxin, Liu, Longbin, Nishimura, Nobuko, Yang, Kevin C, Tadesse, Seifu, Fotsch, Christopher, Chen, Jie, Chmait, Samer, Cupples, Rod, Hale, Clarence, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Van, Gwyneth, St. Jean, David J

“…The glucokinase–glucokinase regulatory protein (GK-GKRP) complex plays an important role in controlling glucose homeostasis in the liver. We have recently…”
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Abstract 2861: Validation of PERK as an oncology target: A role for the unfolded protein response in cancer by Dellamaggiore, Ken, Mitchell, Petia, Sun, Ji-Rong, Jones, Jeffrey, Muchamuel, Tony, Hollenback, David, Tadesse, Seifu, Booker, Shon, Hong, Fang-Tsao, Smith, Adrian, Rose, Mark, Beltran, Pedro, Lipford, James R.

“…Abstract The Unfolded Protein Response (UPR) is a cellular stress response to stressors that induce accumulation of unfolded proteins in the endoplasmic…”
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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles by St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu, Tamayo, Nuria, Van, Gwyneth, Yang, Kevin C., Zhang, Jiandong, Norman, Mark H., Fotsch, Christopher, Lloyd, David J., Hale, Clarence

“…In the previous report, we described the discovery and optimization of novel small molecule disruptors of the GK-GKRP interaction culminating in the…”
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Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511 by Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E

“…The phosphoinositide 3-kinase family catalyzes the phosphorylation of phosphatidylinositol-4,5-diphosphate to phosphatidylinositol-3,4,5-triphosphate, a…”
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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases by Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H

“…A highly selective series of inhibitors of the class I phosphatidylinositol 3-kinases (PI3Ks) has been designed and synthesized. Starting from the dual…”
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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket by Hong, Fang-Tsao, Norman, Mark H, Ashton, Kate S, Bartberger, Michael D, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Tadesse, Seifu, Hale, Clarence, St. Jean, David J

“…Structure–activity relationship investigations conducted at the 5-position of the N-pyridine ring of a series of N-arylsulfonyl-N′-2-pyridinyl-piperazines led…”
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Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening by Subramanian, Raju, Lee, Matthew R, Allen, John G, Bourbeau, Matthew P, Fotsch, Christopher, Hong, Fang-Tsao, Tadesse, Seifu, Yao, Guomin, Yuan, Chester C, Surapaneni, Sekhar, Skiles, Gary L, Wang, Xianghong, Wohlhieter, G. Erich, Zeng, Qingping, Zhou, Yihong, Zhu, Xiaochun, Li, Chun

“…A 2-aminothiazole derivative 1 was developed as a potential inhibitor of the oncology target AKT, a serine/threonine kinase. When incubated in rat and human…”
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Oxopyrido[2,3‑d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors by Wurz, Ryan P, Pettus, Liping H, Ashton, Kate, Brown, James, Chen, Jian Jeffrey, Herberich, Brad, Hong, Fang-Tsao, Hu-Harrington, Essa, Nguyen, Tom, St. Jean, David J, Tadesse, Seifu, Bauer, David, Kubryk, Michele, Zhan, Jinghui, Cooke, Keegan, Mitchell, Petia, Andrews, Kristin L, Hsieh, Faye, Hickman, Dean, Kalyanaraman, Nataraj, Wu, Tian, Reid, Darren L, Lobenhofer, Edward K, Andrews, Dina A, Everds, Nancy, Guzman, Roberto, Parsons, Andrew T, Hedley, Simon J, Tedrow, Jason, Thiel, Oliver R, Potter, Matthew, Radinsky, Robert, Beltran, Pedro J, Tasker, Andrew S

“…In nonsmall cell lung cancer (NSCLC), the threonine790–methionine790 (T790M) point mutation of EGFR kinase is one of the leading causes of acquired resistance…”
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Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511 by Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E

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N-Arylation of Primary and Secondary Aliphatic Amines on Solid Supports by Combs, Andrew P, Tadesse, Seifu, Rafalski, Maria, Haque, Tasir S, Lam, Patrick Y. S

“…A general and mild method for the N-arylation of primary and secondary aliphatic amines is reported. Copper acetate, triethylamine mediated C/N cross-coupling…”
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Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter p ylori Dihydroorotate Dehydrogenase by Haque, Tasir S, Tadesse, Seifu, Marcinkeviciene, Jovita, Rogers, M. John, Sizemore, Christine, Kopcho, Lisa M, Amsler, Karen, Ecret, Lisa D, Zhan, Dong Liang, Hobbs, Frank, Slee, Andrew, Trainor, George L, Stern, Andrew M, Copeland, Robert A, Combs, Andrew P

“…The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach…”
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Solid-Phase Synthesis of Highly Functionalized 2,2‘-Bipyridines by Tadesse, Seifu, Bhandari, Ashok, Gallop, Mark A

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