Search Results - "TADAKI, Douglas K"

Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) by KIRK, Allan D, HALE, Douglas A, MANNON, Roslyn B, KLEINER, David E, HOFFMANN, Steven C, KAMPEN, Robert L, CENDALES, Linda K, TADAKI, Douglas K, HARLAN, David M, SWANSON, S. John

“…Profound T-cell depletion before allotransplantation with gradual posttransplant T-cell repopulation induces a state of donor-specific immune…”
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Metalloproteinase Expression is Associated with Traumatic Wound Failure by Utz, Edward R., B.S, Elster, Eric A., M.D, Tadaki, Douglas K., Ph.D, Gage, Frederick, Perdue, Philip W., M.D, Forsberg, Jonathan A., M.D, Stojadinovic, Alexander, M.D, Hawksworth, Jason S., M.D, Brown, Trevor S., Ph.D

“…Background Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation…”
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Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: effects of extracorporeal shock wave therapy by Zins, Stephen R., Amare, Mihret F., Tadaki, Douglas K., Elster, Eric. A., Davis, Thomas A.

“…Impaired wound healing is a persistent clinical problem which has been treated with mixed results. Studies aimed at elucidating the mechanism of impaired wound…”
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Cryopreservation of human whole blood allows immunophenotyping by flow cytometry up to 30days after cell isolation by Paredes, R. Madelaine, Tadaki, Douglas K., Sooter, Amanda, Gamboni, Fabia, Sheppard, Forest

“…Immunophenotyping of whole blood (WB) by flow cytometry (FC) is used clinically to assess a patient's immune status and also in biomedical research. Current…”
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Generation of complement molecular complex C5b-9 (C5b-9) in response to poly-traumatic hemorrhagic shock and evaluation of C5 cleavage inhibitors in non-human primates by Paredes, R. Madelaine, Reyna, Sarah, Vernon, Philip, Tadaki, Douglas K., Dallelucca, Jurandir J., Sheppard, Forest

“…Severe trauma initiates a systemic inflammatory cascade and that involves early activation of complement and cleavage of C5 into C5a (anaphylatoxin) and C5b…”
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Nonhuman Primate (Rhesus Macaque) Models of Severe Pressure-Targeted Hemorrhagic and Polytraumatic Hemorrhagic Shock by Sheppard, Forest R, Macko, Antoni R, Glaser, Jacob J, Vernon, Philip J, Burdette, Alexander J, Paredes, Ruth Madelaine, Koeller, Craig A, Pusateri, Anthony E, Tadaki, Douglas K, Cardin, Sylvain

“…BACKGROUND:We endeavored to develop clinically translatable nonhuman primate (NHP) models of severe polytraumatic hemorrhagic shock. METHODS:NHPs were…”
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Development of a Nonhuman Primate (Rhesus Macaque) Model of Uncontrolled Traumatic Liver Hemorrhage by Sheppard, Forest R, Macko, Antoni, Fryer, Darren M, Ozuna, Kassandra M, Brown, Alexander K, Crossland, Randy F, Tadaki, Douglas K

“…ABSTRACTHemorrhage is the leading cause of potentially survivable trauma mortality, necessitating the development of improved therapeutic interventions. The…”
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Cerebral Blood Flow in Polytrauma: Transcranial Doppler Analysis in a Nonhuman Primate Shock Model by Pratt, Gilbert Andrew, Hathaway, Emily N., Hemond, Peter J., Tadaki, Douglas K., Sheppard, Forest R., Glaser, Jacob J.

“…In combat-related trauma, resuscitation goals are to attenuate tissue hypoxia and maintain circulation. During hemorrhagic shock, compensatory and…”
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Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates by HE XU, TADAKI, Douglas K, KIRK, Allan D, ELSTER, Eric A, BURKLY, Linda C, BERNING, Justin D, CRUZATA, Francis, KAMPEN, Robert L, MONTGOMERY, Sean P, PATTERSON, Noelle B, HARLAN, David M

“…The anti-CD154 antibody hu5C8 prevents acute allograft rejection and prolongs allograft survival after withdrawal of therapy in nonhuman primates. This study…”
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates by Kirk, Allan D, Burkly, Linda C, Batty, D. Scott, Baumgartner, Roxanne E, Berning, Justin D, Buchanan, Kelvin, Fechner, John H, Germond, Rhonda L, Kampen, Robert L, Patterson, Noelle B, Swanson, S. John, Tadaki, Douglas K, TenHoor, Christopher N, White, Leonard, Knechtle, Stuart J, Harlan, David M

“…CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the…”
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Inflammatory response is associated with critical colonization in combat wounds by Brown, Trevor S, Hawksworth, Jason S, Sheppard, Forest R, Tadaki, Douglas K, Elster, Eric

“…Modern combat- or blast-related injuries are characterized by devastatingly massive zones of injury that violate soft tissue, bone, and neurovascular…”
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Studies Investigating Pretransplant Donor-Specific Blood Transfusion, Rapamycin, and the CD154-Specific Antibody IDEC-131 in a Nonhuman Primate Model of Skin Allotransplantation by Xu, He, Montgomery, Sean P, Preston, Edwin H, Tadaki, Douglas K, Hale, Douglas A, Harlan, David M, Kirk, Allan D

“…Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies suggest that adding pretransplant donor-specific transfusion (DST) and/or…”
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Probabilistic (Bayesian) Modeling of Gene Expression in Transplant Glomerulopathy by Elster, Eric A, Hawksworth, Jason S, Cheng, Orlena, Leeser, David B, Ring, Michael, Tadaki, Douglas K, Kleiner, David E, Eberhardt, John S, Brown, Trevor S, Mannon, Roslyn B

“…Transplant glomerulopathy (TG) is associated with rapid decline in glomerular filtration rate and poor outcome. We used low-density arrays with a novel…”
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Assessment of Cadaveric Organ Viability During Pulsatile Perfusion Using Infrared Imaging by GORBACH, Alexander M, LEESER, David B, HENGLIANG WANG, TADAKI, Douglas K, FERNANDEZ, Carlos, DESTEPHANO, David, HALE, Douglas, KIRK, Allan D, GAGE, Fred A, ELSTER, Eric A

“…Assessment of pulsatile perfusion (PP) is limited to measurements of flow (V) and resistance (R). We investigated infrared (IR) imaging during PP as a means…”
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Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates by ELSTER, Eric A, HE XU, KIRK, Allan D, TADAKI, Douglas K, MONTGOMERY, Sean, BURKLY, Linda C, BERNING, Justin D, BAUMGARTNER, Roxanne E, CRUZATA, Frank, MARX, Richard, HARLAN, David M

“…Allogeneic skin transplantation remains a rigorous test of any immune intervention designed to prevent allograft rejection. To date, no single, clinically…”
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The role of CD154 in organ transplant rejection and acceptance by Kirk, Allan D., Blair, Patrick J., Tadaki, Douglas K., Xu, He, Harlan, David M.

“…CD154 plays a critical role in determining the outcome of a transplanted organ. This simple statement is amply supported by experimental evidence demonstrating…”
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Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction (∗) by French, Anthony R., Tadaki, Douglas K., Niyogi, Salil K., Lauffenburger, Douglas A.

“…Using members of the epidermal growth factor (EGF) family as well as site-directed recombinant human EGF mutants, we investigated how ligand binding properties…”
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Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation by MONTGOMERY, Sean P, HE XU, SWANSON, S. John, HARLAN, David M, KIRK, Allan D, TADAKI, Douglas K, CELNIKER, Abbie, BURKLY, Linda C, BERNING, Justin D, CRUZATA, Francis, ELSTER, Eric A, GRAY, Gary, KAMPEN, Robert L

“…Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing donor-specific tolerance in rodents. These…”
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Development of a Bayesian model to estimate health care outcomes in the severely wounded by Stojadinovic, Alexander, Eberhardt, John, Brown, Trevor S, Hawksworth, Jason S, Gage, Frederick, Tadaki, Douglas K, Forsberg, Jonathan A, Davis, Thomas A, Potter, Benjamin K, Dunne, James R, Elster, E A

“…Graphical probabilistic models have the ability to provide insights as to how clinical factors are conditionally related. These models can be used to help us…”
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QS194. Inflammatory Cytokine and Chemokine Expression Is Associated With Wound Failure in High Energy Penetrating War Injuries by Hawksworth, Jason, Stojadinovic, Alexander, Gage, Fred, Tadaki, Douglas K, Perdue, Philip W, Forsberg, John, Davis, Tom, Brown, Trevor, Elster, Eric A

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