Search Results - "T. V. Grinenko"

PLASMINOGEN AND ANGIOSTATIN LEVELS IN FEMALE BENIGN BREAST LESIONS by Tykhomyrov, A A, Vovchuk, I L, Grinenko, T V

“…It is known that benign breast tissue exhibit relatively low angiogenic capacity. Activation of angiogenesis in mammary pre-malignant lesions could be…”
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Effect of fibrin degradation products on fibrinolytic process by Yatsenko, T A, Rybachuk, V M, Yusova, O I, Kharchenko, S M, Grinenko, T V

“…Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation with subsequent release into bloodstream. The fragments…”
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Plasminogen fragments K 1-3 and K 5 bind to different sites in fibrin fragment DD by Grinenko, T V, Kapustianenko, L G, Yatsenko, T A, Yusova, O I, Rybachuk, V N

“…Specific plasminogen-binding sites of fibrin molecule are located in Аα148-160 regions of C-terminal domains. Plasminogen interaction with these sites…”
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Study of the sites of plasminogen molecule which are responsible for inhibitory effect of Lys-plasminogen on platelet aggregation by Roka-Moya, Y M, Zhernossekov, D D, Yusova, E I, Kapustianenko, L G, Grinenko, T V

“…Plasminogen/plasmin system is involved in such important processes as thrombosis, inflammation and cancer. Plasmin and plasminogen mediate their action through…”
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Plasminogen modulates formation and release of platelet angiogenic regulators by Tykhomyrov, A. A., Zhernosekov, D. D., Grinenko, T. V.

“…Platelets store, produce and release a variety of angiogenesis regulators, which can contribute to both normal tissue repair and angiopathy-associated…”
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Identification of the binding site for plasminogen kringle 5 in the α-chain of fibrin(ogen) D-fragment by L. G. Kapustianenko, T. V. Grinenko, A. V. Rebriev, O. I. Yusova, A. A. Tykhomyrov

“…The interaction of the fifth kringle of Glu-plasminogen with fibrin triggers activation and initiation of fibrinolysis, yet the site on fibrin that binds…”
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Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke by Tykhomyrov, A. A., Kushnir, Yu. S., Nedzvetsky, V. S., Grinenko, T. V., Kuryata, O. V.

“…Ischemic stroke is considered as one of the most frequent and severe complications of atrial fibrillation. The present study was undertaken to examine whether…”
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PRODUCTION AND CHARACTERIZATION OF ANTIBODIES TO TISSUE PLASMINOGEN ACTIVATOR: APPLICATION FOR THE PLATELET FLOW CYTOMETRY ASSAY by Yusova, E. I.

“…Tissue plasminogen activator (tPA) is one of the key protein of plasminogen/plasmin system that converts plasminogen in the active proteinase plasmin…”
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Surface-exposed actin binds plasminogen on the membrane of agonist-activated platelets: a flow cytometry study by Tykhomyrov, A. A., Zhernossekov, D. D., Grinenko, T. V.

“…Aim. To elucidate whether actin exposed on the surface of agonist-activated platelets is responsible for plasminogen binding. Methods. Human washed platelets…”
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Plasminogen modulates formation of reactive oxygen species in human platelets by Tykhomyrov, A. A., Zhernosekov, D. D., Guzyk, M. M., Korsa, V. V., Grinenko, T. V.

“…Reactive oxygen species (ROS) are considered to be important signalling molecules controlling many platelet functions. ROS production has been shown to be…”
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Ca(2+)-dependent regulation of fibrinolytic system activation on fibrin(ogen) D-domains by Yatsenko, T. A., Rybachuk, V. M., Kharchenko, S. M., Grinenko, T. V.

“…In the present study, we investigated whether calcium content modulation in D-domains of fibrin(ogen) was involved in fibrinolytic process activation. To…”
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Clot formation and lysis in platelet rich plasma of healthy donors and patients with resistant hypertension by Patalakh, I. I., Revka, O. V., Kuchmenko, O. B., Matova, O. O., Drobotko, T. F., Grinenko, T. V.

“…Hemostatic balance in blood is affected by numerous factors, including coagulation and fibrinolytic proteins, the wide spectrum of their inhibitors, and blood…”
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Extracellular annexins in hemostasis system by Zhernossekov, D. D., Roka-Moiia, Y. M., Grinenko, T. V.

“…Annexins are calcium-binding proteins that interact with cellular membranes due to their ability to bind phospholipids. The structural and functional…”
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CALIX[4]ARENES METHYLENE BISPHOSPHONIC ACIDS EFFECT ON PLASMIN ACTIVITY by Yusova, O. I.

“…The aim of the work was to study plasmin inhibiting properties of calix[4]arenes functionalized by phosphonic acid residues. The following methods were used:…”
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Glu- and Lys-forms of plasminogen differentially affect phosphatidylserine exposure on the platelet surface by Zhernossekov, D. D., Roka-Moiia, Y. M., Tykhomyrov, A. O., Guzyk, M. M., Grinenko, T. V.

“…Plasminogen/plasmin system is known for its ability to support hemostatic balance of blood. However, plasminogen may be considered as an adhesive ligand and in…”
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Plasminogen and its fragments in rat brain: a plausible role for astrocytes in angiostatin generation by Tykhomyrov, A. A., Nedzvetsky, V. S., Agca, C. A., Korsa, V. V., Grinenko, T. V.

“…The purpose of the present study was to examine the plasminogen localization and to detect levels of its fragments (angiostatins) in various regions of rat…”
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Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension by Yusova, O. I., Savchuk, O. V., Grinenko, T. V., Kuchmenko, O. B.

“…The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type…”
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Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue by Chernyshenko, V. O., Savchuk, O. V., Cherenok, S. O., Silenko, O. M., Negelia, A. O.

“…C-145 (octasodium salt of calix[4]arene-tetra-methylenebisphosphonic acid) was previously considered as specific anti-сoagulant agent that affects fibrin…”
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Novel aspects of platelet aggregation by Roka-Moya, Y. M., Bilous, V. L., Zhernossekov, D. D., Grinenko, T. V.

“…The platelet aggregation is an important process, which is critical for the hemostatic plug formation and thrombosis. Recent studies have shown that the…”
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The role of angiostatins in diabetic complications by Tykhomyrov, A. A., Shram, S. I., Grinenko, T. V.

“…Angiogenesis, a process of formation of new blood vessels form pre-existing vessels, is regulated by a large number of peptide factors. Imbalance of pro- and…”
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