Search Results - "T. D. Lebedev"

Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly by Zhernakova, N I, Bunova, S S, Agarkov, N M, Lebedev, D T, Aksenov, V V

“…Cardiovascular diseases are among the most common causes of disability and death in the world, and the number of patients with this category of diseases is…”
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Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling by Spirin, P V, Lebedev, T D, Orlova, N N, Gornostaeva, A S, Prokofjeva, M M, Nikitenko, N A, Dmitriev, S E, Buzdin, A A, Borisov, N M, Aliper, A M, Garazha, A V, Rubtsov, P M, Stocking, C, Prassolov, V S

“…The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding…”
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Plasmolipin and Its Role in Cell Processes by Shulgin, A. A., Lebedev, T. D., Prassolov, V. S., Spirin, P. V.

“…The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task…”
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The Different Impact of ERK Inhibition on Neuroblastoma, Astrocytoma, and Rhabdomyosarcoma Cell Differentiation by Lebedev, T D, Vagapova, E R, Prassolov, V S

“…Aberrant ERK activity can lead to uncontrolled cell proliferation, immortalization, and impaired cell differentiation. Impairment of normal cell…”
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The Role of TAL1 in Hematopoiesis and Leukemogenesis by Vagapova, E R, Spirin, P V, Lebedev, T D, Prassolov, V S

“…TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates…”
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Lentiviral gene delivery to plasmolipin-expressing cells using Mus caroli endogenous retrovirus envelope protein by Prokofjeva, M.M., Proshkina, G.M., Lebedev, T.D., Shulgin, A.A., Spirin, P.V., Prassolov, V.S., Deyev, S.M.

“…Gene therapy is a promising method for treating malignant diseases. One of the main problems is target delivery of therapeutic genes. Here we show that…”
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Inhibition of Non-Receptor Tyrosine Kinase JAK2 Reduces Neuroblastoma Cell Growth and Enhances the Action of Doxorubicin by Lebedev, T. D., Vagapova, E. R., Astashkova, O. O., Spirin, P. V., Prassolov, V. S.

“…—Novel treatments for various types of malignant diseases are warranted. In this study, we evaluated JAK2 inhibitors (Janus kinase 2) for suppressing the…”
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High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin by Vagapova, E R, Lebedev, T D, Tikhonova, A D, Goikhman, B V, Ivanenko, K A, Spirin, P V, Prassolov, V S

“…Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat…”
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High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin by Vagapova, E. R., Lebedev, T. D., Tikhonova, A. D., Goikhman, B. V., Ivanenko, K. A., Spirin, P. V., Prassolov, V. S.

“…—Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat…”
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Establishment of a FDC-P1 murine cell line with human KIT N822K gene overexpression by Vagapova, Elmira R., Lebedev, T. D., Popenko, V. I., Leonova, O. G., Spirin, P. V., Prasolov, V. S.

“…The mechanism of resistance of leukemia cells to chemotherapeutic drugs remains poorly understood. New model systems for studying the processes of malignant…”
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Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia by Orlova, N. N., Lebedev, T. D., Spirin, P. V., Prassolov, V. S.

“…Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most…”
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Transfer and Expression of Small Interfering RNAs in Mammalian Cells Using Lentiviral Vectors by Lebedev, T D, Spirin, P V, Prassolov, V S

“…RNA interference is a convenient tool for modulating gene expression. The widespread application of RNA interference is made difficult because of the…”
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Comparative analysis of gene expression: Targeted antitumor therapy in neuroblastoma cell lines by Lebedev, T. D., Spirin, P. V., Orlova, N. N., Prokofjeva, M. M., Prassolov, V. S.

“…In this study, we evaluated the level of c-kit, VEGFA , and MYC gene expression in seven neuroblastoma stable cell lines, i.e., SK-N-SH, SK-N-BE, SK-N-AS,…”
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Receptor tyrosine kinase KIT can regulate the expression of genes involved in spontaneous regression of neuroblastoma by Lebedev, T. D., Spirin, P. V., Suntsova, M. V., Ivanova, A. V., Buzdin, A. A., Prokofjeva, M. M., Rubtsov, P. M., Prassolov, V. S.

“…An important feature of neuroblastoma is its ability to spontaneously regress or differentiate into a benign tumor at all stages of the disease; however, the…”
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Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication by Prokofjeva, M. M., Orlova, N. N., Gornostaeva, A. S., Shulgin, A. A., Nikitenko, N. A., Senchenko, V. N., Lebedev, T. D., Spirin, P. V., Riecken, K., Fehse, B., Stocking, C., Prassolov, V. S.

“…A system based on recombinant lentiviral vectors has been designed for safe screening of potential anti-HIV drugs. The system can be used to evaluate the…”
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Specific silencing of leukemic oncogenes using RNA-interference approach by T. D. Lebedev, P. V. Spirin, N. N. Orlova, A. S. Gornostaeva, C. Stocking, V. S. Prassolov

“…RNA-interference is an effective natural mechanism of post-transcriptional modulation of gene expression. RNA-interference mechanism exists as in high…”
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Modulation of activated oncogene c-kit expression with RNA-interference by Spirin, P. V., Nikitenko, N. A., Lebedev, T. D., Rubtsov, P. M., Stocking, C., Prasolov, V. S.

“…Overexpression of oncogene c-kit is detected in 80% patients with acute myeloid leukemia (AML). A transgenic model cell line expressing oncogene c-kit was…”
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RNA interference and deep sequencing as tools for identifying new genes involved in leukemogenesis by Lebedev, T. D., Spirin, P. V., Orlova, N. N., Kudryavtseva, A. V., Melnikova, N. V., Speranskaya, A. S., Prasolov, V. S.

“…The establishment of the molecular mechanisms of occurrence and progression of oncological diseases and the development of effective tools to combat them is an…”
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The medical significance of loneliness and social isolation in old age (literature review). by Lebedev, D T, Rukavishnikov, A S, Lupashko, E V, Khokhlyuk, E V, Saginbaev, U R

“…Communication is considered as one of the basic human needs. For a long time, loneliness and social isolation were mainly considered as a psychosocial problem…”
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Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia by Orlova, N N, Lebedev, T D, Spirin, P V, Prassolov, V S

“…Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most…”
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