Search Results - "T. Backman, Janne"

Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation by Tornio, Aleksi, Filppula, Anne M., Niemi, Mikko, Backman, Janne T.

“…Many drug–drug interactions (DDIs) are based on alterations of the plasma concentrations of a victim drug due to another drug causing inhibition and/or…”
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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions by Backman, Janne T, Filppula, Anne M, Niemi, Mikko, Neuvonen, Pertti J

“…During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is…”
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VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection by Räsänen, Markus, Degerman, Joni, Nissinen, Tuuli A., Miinalainen, Ilkka, Kerkelä, Risto, Siltanen, Antti, Backman, Janne T., Mervaala, Eero, Hulmi, Juha J., Kivelä, Riikka, Alitalo, Kari

“…Congestive heart failure is one of the leading causes of disability in long-term survivors of cancer. The anthracycline antibiotic doxorubicin (DOX) is used to…”
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In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors by Filppula, Anne M, Neuvonen, Pertti J, Backman, Janne T

“…Previous studies have shown that several protein kinase inhibitors are time-dependent inhibitors of cytochrome P450 (CYP) 3A. We screened 14 kinase inhibitors…”
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Enantiospecific Pharmacogenomics of Fluvastatin by Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Kiander, Wilma, Kidron, Heidi, Paile‐Hyvärinen, Maria, Tapaninen, Tuija, Backman, Janne T., Niemi, Mikko

“…The aim of this study was to investigate how variability in multiple genes related to pharmacokinetics affects fluvastatin exposure. We determined fluvastatin…”
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Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin by Neuvonen, Pertti J., Backman, Janne T., Niemi, Mikko

“…HMG-CoA reductase inhibitors (statins) dose-dependently lower both the level of low-density lipoprotein cholesterol and risk of cardiovascular disease. In…”
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Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans by Itkonen, Matti K, Tornio, Aleksi, Neuvonen, Mikko, Neuvonen, Pertti J, Niemi, Mikko, Backman, Janne T

“…A recent in vitro study suggested that CYP2C8 is essential in the metabolism of desloratadine, an H1 receptor antagonist. If the proposed biotransformation…”
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Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review by Kuula, Laura S M, Viljemaa, Kati M, Backman, Janne T, Blom, Marja

“…Adverse events (AEs) associated with the use of fluoroquinolone antimicrobials include Clostridium difficile associated diarrhea (CDAD), liver injury and…”
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Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters by Tornio, Aleksi, Neuvonen, Pertti J, Niemi, Mikko, Backman, Janne T

“…Cytochrome P450 (CYP) 2C8 is a drug metabolizing enzyme of major importance. The lipid-lowering drug gemfibrozil has been identified as a strong inhibitor of…”
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Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers by Shyamsundar, Murali, McKeown, Scott T. W, O'Kane, Cecilia M, Craig, Thelma R, Brown, Vanessa, Thickett, David R, Matthay, Michael A, Taggart, Clifford C, Backman, Janne T, Elborn, J. Stuart, McAuley, Daniel F

“…Simvastatin inhibits inflammatory responses in vitro and in murine models of lung inflammation in vivo. As simvastatin modulates a number of the underlying…”
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Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers by Lohela, Terhi J., Poikola, Satu, Neuvonen, Mikko, Niemi, Mikko, Backman, Janne T., Olkkola, Klaus T., Lilius, Tuomas O.

“…BACKGROUND:Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such…”
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Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function by Hämäläinen, Kreetta, Hirvensalo, Päivi, Neuvonen, Mikko, Tornio, Aleksi, Backman, Janne T., Lehtonen, Marko, Niemi, Mikko

“…Our aim was to evaluate biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) function using a hypothesis‐free metabolomics approach. We analyzed…”
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Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response by Filppula, Anne M, Neuvonen, Mikko, Laitila, Jouko, Neuvonen, Pertti J, Backman, Janne T

“…Recent data suggest that the role of CYP3A4 in imatinib metabolism is smaller than presumed. This study aimed to evaluate the quantitative importance of…”
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Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle by Hulmi, Juha J., Nissinen, Tuuli A., Räsänen, Markus, Degerman, Joni, Lautaoja, Juulia H., Hemanthakumar, Karthik Amudhala, Backman, Janne T., Ritvos, Olli, Silvennoinen, Mika, Kivelä, Riikka

“…Background Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of…”
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Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction by Tapaninen, Tuija, Olkkola, Aleksi M., Tornio, Aleksi, Neuvonen, Mikko, Elonen, Erkki, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.

“…The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable…”
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Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis by Morel, Jerome, Hargreaves, Iain, Brealey, David, Neergheen, Viruna, Backman, Janne T, Lindig, Sandro, Bläss, Marcus, Bauer, Michael, McAuley, Daniel F, Singer, Mervyn

“…Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated the effects of…”
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Trimethoprim and the CYP2C83 Allele Have Opposite Effects on the Pharmacokinetics of Pioglitazone by TORNIO, Aleksi, NIEMI, Mikko, NEUVONEN, Pertti J, BACKMAN, Janne T

“…We studied the effects of the CYP2C8 inhibitor trimethoprim and CYP2C8 genotype on the pharmacokinetics of the antidiabetic pioglitazone. In a randomized…”
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The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study by Simonen, Piia, Ulander, Lotta, Eklund, Kari K., Niemi, Mikko, Backman, Janne T., Gylling, Helena, Sinisalo, Juha

“…Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in…”
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Pharmacogenomics of celiprolol – evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics by Hirvensalo, Päivi, Tornio, Aleksi, Tapaninen, Tuija, Paile‐Hyvärinen, Maria, Neuvonen, Mikko, Backman, Janne T., Niemi, Mikko

“…The aim of this study was to search for associations of genetic variants with celiprolol pharmacokinetics in a large set of pharmacokinetic genes, and, more…”
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Healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions by Kuula, Laura S.M., Backman, Janne T., Blom, Marja L.

“…The aim of this study was to estimate healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions in Finland from 2008 to…”
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