Search Results - "T M de Rosales, Rafael"
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Bisphosphonate-Anchored PEGylation and Radiolabeling of Superparamagnetic Iron Oxide: Long-Circulating Nanoparticles for in Vivo Multimodal (T1 MRI-SPECT) Imaging
Published in ACS nano (22-01-2013)“…The efficient delivery of nanomaterials to specific targets for in vivo biomedical imaging is hindered by rapid sequestration by the reticuloendothelial system…”
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Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging
Published in Chemical reviews (08-06-2022)“…The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical application in a rational manner depends on reliable, clinically…”
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Imaging Nanomedicine-Based Drug Delivery: a Review of Clinical Studies
Published in Molecular imaging and biology (01-10-2018)“…Imaging plays a key role in the preclinical evaluation of nanomedicine-based drug delivery systems and it has provided important insights into their mechanism…”
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Harnessing Nanomedicine to Potentiate the Chemo-Immunotherapeutic Effects of Doxorubicin and Alendronate Co-Encapsulated in Pegylated Liposomes
Published in Pharmaceutics (01-11-2023)“…Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death inducer, in pegylated (Stealth) liposomes, is well known to have major…”
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5
Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
Published in ACS nano (27-02-2018)“…The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast…”
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Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation
Published in Small (Weinheim an der Bergstrasse, Germany) (01-04-2021)“…Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune…”
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Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain
Published in Scientific reports (28-04-2023)“…Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics and imaging agents across the blood–brain barrier. Uniform treatment…”
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8
Microwave-assisted synthesis of [52Mn]Mn-porphyrins: Applications in cell and liposome radiolabelling
Published in Nuclear medicine and biology (01-11-2022)“…Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and as paramagnetic MRI…”
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Liposome delivery to the brain with rapid short-pulses of focused ultrasound and microbubbles
Published in Journal of controlled release (01-01-2022)“…Liposomes are clinically used drug carriers designed to improve the delivery of drugs to specific tissues while minimising systemic distribution. However,…”
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NHS-Functionalized THP Derivative for Efficient Synthesis of Kit-Based Precursors for 68Ga Labeled PET Probes
Published in Biomedicines (01-04-2021)“…Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentrations and their high affinities for oxophilic trivalent metal ions…”
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Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility
Published in ACS nano (26-04-2022)“…Throughout the female menstrual cycle, physiological changes occur that affect the biodistribution of nanoparticles within the reproductive system. We…”
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Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines
Published in ACS nano (22-11-2016)“…The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body…”
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Manganese-52: applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore
Published in Dalton transactions : an international journal of inorganic chemistry (2018)“…The ionophore 8-hydroxyquinoline (oxine) has been used to radiolabel cells and liposomal medicines with 111In and, more recently, 89Zr, for medical nuclear…”
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14
68Ga-bisphosphonates for the imaging of extraosseous calcification by positron emission tomography
Published in Scientific reports (05-09-2023)“…Radiolabelled bisphosphonates (BPs) and [ 18 F]NaF ( 18 F-fluoride) are the two types of radiotracers available to image calcium mineral (e.g. bone), yet only…”
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15
PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling
Published in Bioconjugate chemistry (16-03-2022)“…Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease…”
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On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
Published in ACS applied materials & interfaces (27-07-2022)“…Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and…”
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[68Ga]Ga-THP-Pam: A Bisphosphonate PET Tracer with Facile Radiolabeling and Broad Calcium Mineral Affinity
Published in Bioconjugate chemistry (21-07-2021)“…Calcium minerals such as hydroxyapatite (HAp) can be detected noninvasively in vivo using nuclear imaging agents such as [18F]NaF (available from cyclotrons),…”
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Mechanisms of inclusion of thallium-201 into Prussian blue nanoparticles for nuclear medicine applications
Published in Journal of materials chemistry. B, Materials for biology and medicine (22-08-2024)“…Prussian blue is known for its high affinity for thallium and other univalent metal cations and has been used as a treatment for radiocaesium and…”
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[Ga]Ga-THP-tetrazine for bioorthogonal click radiolabelling: pretargeted PET imaging of liposomal nanomedicines
Published in RSC chemical biology (03-07-2024)“…Pretargeted PET imaging using bioorthogonal chemistry is a leading strategy for the tracking of long-circulating agents such as antibodies and…”
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Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents
Published in Advanced functional materials (01-04-2014)“…Carbon nanotubes (CNTs) are one of the most promising nanomaterials to be used in biomedicine for drug/gene delivery as well as biomedical imaging. This study…”
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