Search Results - "T’jollyn, Huybrecht"

The AAPS Journal Theme Issue: “Perspectives on Clinical Drug Development of Long-Acting Injectables” by T’jollyn, Huybrecht, Ackaert, Oliver

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PBPK and its Virtual Populations: the Impact of Physiology on Pediatric Pharmacokinetic Predictions of Tramadol by T’jollyn, Huybrecht, Vermeulen, An, Van Bocxlaer, Jan

“…In pediatric PBPK models, age-related changes in the body are known to occur. Given the sparsity of and the variability associated with relevant physiological…”
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Plasma and Liver Pharmacokinetics of the N-Acetylgalactosamine Short Interfering RNA JNJ-73763989 in Recombinant Adeno-Associated–Hepatitis B Virus–Infected Mice by Sandra, Louis, T’jollyn, Huybrecht, Goeyvaerts, Nele, Vermeulen, An, Dosne, Anne-Gaëlle, Perez-Ruixo, Juan-Jose

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Efficacy and safety exposure–response relationships of apalutamide in patients with metastatic castration-sensitive prostate cancer: results from the phase 3 TITAN study by T’jollyn, Huybrecht, Ackaert, Oliver, Chien, Caly, Lopez-Gitlitz, Angela, McCarthy, Sharon, Ruixo, Carlos Perez, Karsh, Lawrence, Chi, Kim, Chowdhury, Simon, Ruixo, Juan-Jose Perez, Agarwal, Neeraj

“…Purpose Apalutamide plus androgen-deprivation therapy (ADT) has been approved for treatment of patients with metastatic castration-sensitive prostate cancer…”
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Model-Informed Clinical Development of 6-Monthly Injection of Paliperidone Palmitate in Patients with Schizophrenia: Dosing Strategies Guided by Population Pharmacokinetic Modeling and Simulation (Part II) by T’jollyn, Huybrecht, Venkatasubramanian, Raja, Neyens, Martine, Gopal, Srihari, Russu, Alberto, Nandy, Partha, Perez-Ruixo, Juan Jose, Ackaert, Oliver

“…Background and Objective Paliperidone palmitate 6-month (PP6M) intramuscular (IM) injection is the longest-acting treatment available for patients with…”
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A Physiologically Based Pharmacokinetic Perspective on the Clinical Utility of Albumin-Based Dose Adjustments in Critically Ill Patients by T’jollyn, Huybrecht, Vermeulen, An, Van Bocxlaer, Jan, Colin, Pieter

“…Introduction In hypo-albuminemia, the extent of albumin binding of a drug decreases. The resulting change in plasma protein binding only rarely leads to…”
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Model-Informed Clinical Development of Once-Every-6-Month Injection of Paliperidone Palmitate in Patients with Schizophrenia: A Pharmacometric Bridging Approach (Part I) by T’jollyn, Huybrecht, Russu, Alberto, Venkatasubramanian, Raja, Gopal, Srihari, Nandy, Partha, Neyens, Martine, Faelens, Ruben, Samtani, Mahesh N., Ackaert, Oliver, Perez-Ruixo, Juan Jose

“…Background and Objective A model-informed drug development (MIDD) approach was implemented for paliperidone palmitate (PP) 6-month (PP6M) clinical development,…”
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Model‐based meta‐analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B‐infected mice by Sandra, Louis, T'jollyn, Huybrecht, Vermeulen, An, Ackaert, Oliver, Perez‐Ruixo, Juan‐Jose

“…The objective of this study was to compare the efficacy of short interfering RNA therapeutics (siRNAs) in reducing hepatitis B surface antigen (HBsAg) levels…”
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Physiology-Based IVIVE Predictions of Tramadol from in Vitro Metabolism Data by T’jollyn, Huybrecht, Snoeys, Jan, Colin, Pieter, Van Bocxlaer, Jan, Annaert, Pieter, Cuyckens, Filip, Vermeulen, An, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Boussery, Koen

“…ABSTRACT Purpose To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro - in vivo extrapolation…”
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Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation by T’jollyn, Huybrecht, Snoeys, Jan, Vermeulen, An, Michelet, Robin, Cuyckens, Filip, Mannens, Geert, Van Peer, Achiel, Annaert, Pieter, Allegaert, Karel, Van Bocxlaer, Jan, Boussery, Koen

“…This paper focuses on the retrospective evaluation of physiologically based pharmacokinetic (PBPK) techniques used to mechanistically predict clearance…”
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Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro–In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound by T’jollyn, Huybrecht, Snoeys, Jan, Van Bocxlaer, Jan, De Bock, Lies, Annaert, Pieter, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Vermeulen, An, Boussery, Koen

“…Background and Objective Although the measurement of cytochrome P450 (CYP) contributions in metabolism assays is straightforward, determination of actual in…”
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A Randomized, Double-Blind, Multicenter, Noninferiority Study Comparing Paliperidone Palmitate 6-Month Versus the 3-Month Long-Acting Injectable in Patients With Schizophrenia by Najarian, Dean, Sanga, Panna, Wang, Steven, Lim, Pilar, Singh, Arun, Robertson, Mary Jane, Cohen, Kristin, Schotte, Alain, Milz, Ruth, Venkatasubramanian, Raja, T’Jollyn, Huybrecht, Walling, David P, Galderisi, Silvana, Gopal, Srihari

“…Abstract Background This double-blind (DB), randomized, parallel-group study was designed to evaluate efficacy and safety of paliperidone palmitate 6-month…”
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First-in-human, open-label, phase 1/2 study of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced cancers by Felip, Enriqueta, Moreno, Victor, Morgensztern, Daniel, Curigliano, Giuseppe, Rutkowski, Piotr, Trigo, José Manuel, Calvo, Aitana, Kowalski, Dariusz, Cortinovis, Diego, Plummer, Ruth, Maio, Michele, Ascierto, Paolo A., Vladimirov, Vladimir I., Cervantes, Andres, Zudaire, Enrique, Hazra, Anasuya, T’jollyn, Huybrecht, Bandyopadhyay, Nibedita, Greger, James G., Attiyeh, Edward, Xie, Hong, Calvo, Emiliano

“…Purpose To assess the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of cetrelimab (JNJ-63723283), a monoclonal antibody programmed cell…”
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Development and validation of a fast and sensitive UPLC–MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity by De Bock, Lies, Boussery, Koen, Colin, Pieter, De Smet, Julie, T’Jollyn, Huybrecht, Van Bocxlaer, Jan

“…► The development of a UPLC–MS/MS method for in vitro CYP activity determination. ► A generic, fast gradient for detection of all metabolites. ► The method was…”
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Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography–electrospray-tandem mass spectrometry by Colin, Pieter, De Bock, Lies, T'jollyn, Huybrecht, Boussery, Koen, Van Bocxlaer, Jan

“…Monitoring of plasma antibiotic concentrations is necessary for individualization of antimicrobial chemotherapy dosing in special patient populations. One of…”
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Moxifloxacin dosing in post‐bariatric surgery patients by Colin, Pieter, Eleveld, Douglas J., Struys, Michel M. R. F., T'Jollyn, Huybrecht, Bortel, Luc M. Van, Ruige, Johannes, De Waele, Jan, Van Bocxlaer, Jan, Boussery, Koen

“…Introduction Given the ever increasing number of obese patients and obesity related bypass surgery, dosing recommendations in the post‐bypass population are…”
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Understanding the dynamics of HBsAg decline through model-informed drug development (MIDD) of JNJ-3989 and JNJ-6379 for the treatment of chronic hepatitis B virus infection (CHB) by T’jollyn, Huybrecht, Goeyvaerts, Nele, Kakuda, Thomas, Sandra, Louis, Ogawa, Tetsuro, Vandenbossche, Joris J, de Trixhe, Xavier Woot, Lenz, Oliver, Kalmeijer, Ronald, Biermer, Michael, Perez Ruixo, Juan Jose, Ackaert, Oliver

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