Search Results - "Türeci, O."

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study by Türeci, O., Sahin, U., Schulze-Bergkamen, H., Zvirbule, Z., Lordick, F., Koeberle, D., Thuss-Patience, P., Ettrich, T., Arnold, D., Bassermann, F., Al-Batran, S.E., Wiechen, K., Dhaene, K., Maurus, D., Gold, M., Huber, C., Krivoshik, A., Arozullah, A., Park, J.W., Schuler, M.

“…Claudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity…”
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Translation of genomics-guided RNA-based personalised cancer vaccines: towards the bedside by Boisguérin, V, Castle, J C, Loewer, M, Diekmann, J, Mueller, F, Britten, C M, Kreiter, S, Türeci, Ö, Sahin, U

“…Cancer is a disease caused by DNA mutations. Cancer therapies targeting defined functional mutations have shown clinical benefit. However, as 95% of the…”
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Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo by Kuhn, A N, Diken, M, Kreiter, S, Selmi, A, Kowalska, J, Jemielity, J, Darzynkiewicz, E, Huber, C, Türeci, Ö, Sahin, U

“…Vaccination with in vitro transcribed RNA coding for tumor antigens is considered a promising approach for cancer immunotherapy and has already entered human…”
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FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma by Sahin, U., Türeci, Ö., Manikhas, G., Lordick, F., Rusyn, A., Vynnychenko, I., Dudov, A., Bazin, I., Bondarenko, I., Melichar, B., Dhaene, K., Wiechen, K., Huber, C., Maurus, D., Arozullah, A., Park, J.W., Schuler, M., Al-Batran, S.-E.

“…Claudin 18.2 (CLDN18.2) is contained within normal gastric mucosa epithelial tight junctions; upon malignant transformation, CLDN18.2 epitopes become exposed…”
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Expression of a Novel Transmembrane Carbonic Anhydrase Isozyme XII in Normal Human Gut and Colorectal Tumors by Kivelä, Antti, Parkkila, Seppo, Saarnio, Juha, Karttunen, Tuomo J., Kivelä, Jyrki, Parkkila, Anna-Kaisa, Waheed, Abdul, Sly, William S., Grubb, Jeffrey H., Shah, Gul, Türeci, Özlem, Rajaniemi, Hannu

“…Carbonic anhydrase isozyme XII is a recently discovered member of the α-carbonic anhydrase gene family with a suggested role in von Hippel-Lindau gene-mediated…”
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Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α by Koslowski, M, Luxemburger, U, Türeci, Ö, Sahin, U

“…Hypoxia-inducible factor 1α (HIF-1α) is frequently overexpressed in human cancers and controls the expression of several genes that have been implicated in…”
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Expression of the Membrane-associated Carbonic Anhydrase Isozyme XII in the Human Kidney and Renal Tumors by Parkkila, Seppo, Parkkila, Anna-Kaisa, Saarnio, Juha, Kivela, Jyrki, Karttunen, Tuomo J, Kaunisto, Kari, Waheed, Abdul, Sly, William S, Tureci, Ozlem, Virtanen, Ismo, Rajaniemi, Hannu

“…Carbonic anhydrase isozyme XII (CA XII) is a novel membrane-associated protein with a potential role in von Hippel–Lindau carcinogenesis. Although Northern…”
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Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation by Diken, M, Kreiter, S, Selmi, A, Britten, C M, Huber, C, Türeci, Ö, Sahin, U

“…Even though it is known for more than one decade that antigen-encoding RNA can deliver antigenic information to induce antigen-specific immunity against…”
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Autoantibodies in lung cancer: possibilities for early detection and subsequent cure by Chapman, C J, Murray, A, McElveen, J E, Sahin, U, Luxemburger, U, Türeci, O, Wiewrodt, R, Barnes, A C, Robertson, J F

“…People with lung cancer usually present at a late stage in the course of their disease when their chances of long-term survival are low. At present there is…”
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A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer by Reppert, S., Boross, I., Koslowski, M., Türeci, Ö., Koch, S., Lehr, H.A., Finotto, S.

“…Lung cancer is the leading cause of cancer deaths worldwide. The cytokine interleukin-17A supports tumour vascularization and growth, however, its role in lung…”
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T-cell receptor transfer into human T cells with ecotropic retroviral vectors by Koste, L, Beissert, T, Hoff, H, Pretsch, L, Türeci, Ö, Sahin, U

“…Adoptive T-cell transfer for cancer immunotherapy requires genetic modification of T cells with recombinant T-cell receptors (TCRs). Amphotropic retroviral…”
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Serological identification of human tumor antigens by Sahin, Ugur, Türeci, Özlem, Pfreundschuh, Michael

“…Using the antibody repertoire of cancer patients for the systematic search for human tumor antigens, a plenitude of new human tumor antigens has been…”
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Human Neoplasms Elicit Multiple Specific Immune Responses in the Autologous Host by Sahin, Ugur, Tureci, Ozlem, Schmitt, Holger, Cochlovius, Bjorn, Johannes, Thomas, Schmits, Rudolf, Stenner, Frank, Luo, Guorong, Schobert, Ingrid, Pfreundschuh, Michael

“…Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and Hodgkin disease in Escherichia coli and screening for clones reactive with…”
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A Testicular Antigen Aberrantly Expressed in Human Cancers Detected by Autologous Antibody Screening by Chen, Yao-Tseng, Scanlan, Matthew J., Sahin, Ugur, Türeci, Özlem, Gure, Ali O., Tsang, Solam, Williamson, Barbara, Stocker, Elisabeth, Pfreundschuh, Michael, Old, Lloyd J.

“…Serological analysis of recombinant cDNA expression libraries (SEREX) using tumor mRNA and autologous patient serum provides a powerful approach to identify…”
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Characterization of human colon cancer antigens recognized by autologous antibodies by Scanlan, Matthew J., Chen, Yao‐Tseng, Williamson, Barbara, Gure, Ali O., Stockert, Elisabeth, Gordan, John D., Türeci, Özlem, Sahin, Ugur, Pfreundschuh, Michael, Old, Lloyd J.

“…The screening of cDNA expression libraries derived from human tumors with autologous antibody (SEREX) has proven to be a powerful method for defining the…”
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866 A Highly Specific Cancer Target, Regulated Via Promoter Methylation by Wagner, M, Paret, C, Koslowski, M, Kneip, C, Tureci, O, Sahin, U

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Human Carbonic Anhydrase XII: cDNA Cloning, Expression, and Chromosomal Localization of a Carbonic Anhydrase Gene that is Overexpressed in Some Renal Cell Cancers by Tureci, Ozlem, Sahin, Ugur, Vollmar, Evi, Siemer, Stefan, Gottert, Elisabeth, Seitz, Gerhard, Parkkila, Anna-Kaisa, Shah, Gul N., Grubb, Jeffrey H., Pfreundschuh, Michael, Sly, William S.

“…We report the cloning and characterization of a tumor-associated carbonic anhydrase (CA) that was identified in a human renal cell carcinoma (RCC) by…”
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Identification of a Meiosis-Specific Protein as a Member of the Class of Cancer/Testis Antigens by Tureci, Ozlem, Sahin, Ugur, Zwick, Carsten, Koslowski, Michael, Seitz, Gerhard, Pfreundschuh, Michael

“…Little is known about the function of human cancer/testis antigens (CTAs), such as MAGE, BAGE, GAGE, HOM-MEL-40, and NY-ESO-1, the expression of which is…”
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SSX: A multigene family with several members transcribed in normal testis and human cancer by Gure, Ali O., Türeci, Özlem, Sahin, Ugur, Tsang, Solam, Scanlan, Matthew J., Jäger, Elke, Knuth, Alexander, Pfreundschuh, Michael, Old, Lloyd J., Chen, Yao‐Tseng

“…Analysis of t(X;18) translocation in synovial sarcoma had previously led to the definition of the SSX2 gene, the fusion partner on chromosome X. Subsequent…”
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Molecular Definition of a Novel Human Galectin Which Is Immunogenic in Patients with Hodgkin's Disease by Türeci, Özlem, Schmitt, Holger, Fadle, Natalie, Pfreundschuh, Michael, Sahin, Ugur

“…Using autologous serum for the immunoscreening of a cDNA expression library derived from tissue involved by Hodgkin's disease, a new 36-kDa protein with the…”
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