Search Results - "Tötterman, T H"

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients by Schiza, A, Wenthe, J, Mangsbo, S, Eriksson, E, Nilsson, Anders, Tötterman, T H, Loskog, A, Ullenhag, G

“…Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do…”
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Optimization of the MB49 mouse bladder cancer model for adenoviral gene therapy by Loskog, A, Ninalga, C, Hedlund, T, Alimohammadi, M, Malmstrom, P.U, Totterman, T.H

“…Bladder cancer is regarded as a promising candidate for innovative therapies in the field of immune and gene therapy. In this paper, we present the…”
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Characterization of CMVpp65-specific CD8+ T lymphocytes using MHC tetramers in kidney transplant patients and healthy participants by ENGSTRAND, M, TOURNAY, C, PEYRAT, M. A, ERIKSSON, B.-M, WADSTRÖM, J, WIRGART, B. Z, ROMAGNE, F, BONNEVILLE, M, TÖTTERMAN, T. H, KORSGREN, O

“…Cytomegalovirus (CMV) is a ubiquitous herpesvirus that infects 50-90% of individuals in different populations. After primary infection, the virus persists…”
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Efficient adenovirus-mediated gene transduction of normal and leukemic hematopoietic cells by HUANG, M. R, OLSSON, M, KALLIN, A, PETTERSSON, U, TÖTTERMAN, T. H

“…We evaluated the efficiency of adenovirus-mediated gene transfer into normal and malignant human hematopoietic cells. An E-1 and E-3 deleted,…”
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Human urinary bladder carcinomas express adenovirus attachment and internalization receptors by LOSKOG, A, HEDLUND, T, WESTER, K, DE LA TORRE, M, PHILIPSON, L, MALMSTRÖM, P-U, TÖTTERMAN, T. H

“…The use of adenoviral vectors as potent gene delivery systems requires expression of the Coxsackievirus/adenovirus receptor (CVADR) on the target cell surface…”
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Cytomegalovirus‐Specific CD4 and CD8 T Cell Responses in Infants and Children by Lidehäll, A. K., Engman, M.‐L., Sund, F., Malm, G., Lewensohn‐Fuchs, I., Ewald, U., Tötterman, T. H., Karltorp, E., Korsgren, O., Eriksson, B.‐M.

“…Congenital cytomegalovirus (CMV) infection is the most common congenital infection causing childhood morbidity. The pathogenetic mechanisms behind long‐term…”
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An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood by Danielsson, A, Elgue, G, Nilsson, B M, Nilsson, B, Lambris, J D, Tötterman, T H, Kochanek, S, Kreppel, F, Essand, M

“…Polyethylene glycol coating (PEGylation) of adenovirus serotype 5 (Ad5) has been shown to effectively reduce immunogenicity and increase circulation time of…”
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Kick-starting the cancer-immunity cycle by targeting CD40 by Ellmark, P, Mangsbo, S M, Furebring, C, Tötterman, T H, Norlén, P

“…Stimulation of CD40 on dendritic cells to expand and activate tumor-specific T cells and generate anticancer immunity is an attractive therapeutic approach…”
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Soluble vascular cell adhesion molecule‐1 (sVCAM‐1) is an independent prognostic marker in Hodgkin's disease by Christiansen, Ilse, SundstrÖm, Christer, Enblad, Gunilla, Tötterman, Thomas H.

“…Serum levels of soluble vascular cell adhesion molecule‐1 (sVCAM‐1, sCD106) were significantly elevated in patients with Hodgkin's disease (HD) (n = 101)…”
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Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro by Lund, T, Mangsbo, S M, Scholz, H, Gjorstrup, P, Tötterman, T H, Korsgren, O, Foss, A

“…In clinical islet transplantation, inflammatory responses initiated by the transplanted islets and by the host immune system cause acute and chronic graft…”
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Elevated serum levels of soluble vascular cell adhesion molecule‐1 (sVCAM‐1) closely reflect tumour burden in chronic B‐lymphocytic leukaemia by Christiansen, Ilse, Sundström, Christer, Tötterman, Thomas H.

“…The present study is the first to report elevated serum levels of soluble (s)VCAM‐1 in B‐cell chronic lymphocytic leukaemia (B‐CLL). A large cohort of 106…”
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An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer by Cheng, W-S, Dzojic, H, Nilsson, B, Tötterman, T H, Essand, M

“…The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a…”
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Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment by ENGSTRAND, M., LIDEHÄLL, A. K., TÖTTERMAN, T. H., HERRMAN, B., ERIKSSON, B.‐M., KORSGREN, O.

“…SUMMARY The availability of tetrameric complexes of HLA class I molecules folded with immunodominant peptides makes it possible to utilize flow cytometry for…”
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Circadian rhythm of serum interleukin-6 in rheumatoid arthritis by Arvidson, N G, Gudbjörnsson, B, Elfman, L, Rydén, A C, Tötterman, T H, Hällgren, R

“…OBJECTIVES--To test the hypothesis of a diurnal variation in circulating levels of interleukin-6 (IL-6) and/or tumour necrosis factor-alpha (TNF-alpha) in…”
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A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies by GIDLÖF, C, DOHLSTEN, M, LANDO, P, KALLAND, T, SUNDSTRÖM, C, TÖTTERMAN, T. H

“…The bacterial superantigen staphylococcal enterotoxin A (SEA) is an efficient activator of cytotoxic T cells when presented on major histocompatibility complex…”
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Stimulation of NK cell, T cell, and monocyte functions by the novel immunomodulator Linomide after autologous bone marrow transplantation. A pilot study in patients with acute myeloid leukemia by Bengtsson, M, Simonsson, B, Carlsson, K, Nilsson, B, Smedmyr, B, Termander, B, Oberg, G, Tötterman, T H

“…Immunostimulatory therapy is at present considered after autologous bone marrow transplantation (ABMT) in order to mimic the allogeneic graft-versus-leukemia…”
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Adoptive T-cell therapy for malignant melanoma patients with TILs obtained by ultrasound-guided needle biopsy by Ullenhag, Gustav J., Sadeghi, Arian M., Carlsson, Björn, Ahlström, Håkan, Mosavi, Firas, Wagenius, Gunnar, Tötterman, Thomas H.

“…Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate objective responses in up to 50% of malignant melanoma patients with a good…”
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Is primary biliary cirrhosis an autoimmune disease? by Björkland, A, Tötterman, T H

“…This review summarizes the experimental and clinical support for an autoimmune origin of primary biliary cirrhosis (PBC). Direct proof is lacking, but…”
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Ex Vivo PKH26‐Labelling of Lymphocytes for Studies of Cell Migration In Vivo by JOHNSSON, C., FESTIN, R., TUFVESON, G., TÖTTERMAN, T. H.

“…A prerequisite for studies of cell migration is that the cells of interest can be appropriately labelled and subsequently easily traced. The use of…”
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Antibody-directed superantigen-mediated T-cell killing of myeloid leukaemic cell line cells by Gidlöf, Cecilia, Carlson, Barbro, Dohlsten, Mikael, Tötterman, Thomas H.

“…: Bacterial superantigens (SAgs) bound to MHC class II molecules on target cells are efficient activators of cytotoxic T cells expressing certain T cell…”
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