Search Results - "Töllner, Kathrin"

Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy by Twele, Friederike, Töllner, Kathrin, Brandt, Claudia, Löscher, Wolfgang

“…Abstract The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy is increasingly being used for studies on epileptogenesis and…”
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Effective termination of status epilepticus by rational polypharmacy in the lithium–pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers by Brandt, Claudia, Töllner, Kathrin, Klee, Rebecca, Bröer, Sonja, Löscher, Wolfgang

“…Abstract The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the…”
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The organic anion transport inhibitor probenecid increases brain concentrations of the NKCC1 inhibitor bumetanide by Töllner, Kathrin, Brandt, Claudia, Römermann, Kerstin, Löscher, Wolfgang

“…Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal…”
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Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy by Bar-Klein, Guy, Klee, Rebecca, Brandt, Claudia, Bankstahl, Marion, Bascuñana, Pablo, Töllner, Kathrin, Dalipaj, Hotjensa, Bankstahl, Jens P., Friedman, Alon, Löscher, Wolfgang

“…Objective Acquired epilepsy is a devastating long‐term risk of various brain insults, including trauma, stroke, infections, and status epilepticus (SE). There…”
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The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice by Erker, Thomas, Brandt, Claudia, Töllner, Kathrin, Schreppel, Philipp, Twele, Friederike, Schidlitzki, Alina, Löscher, Wolfgang

“…Summary Objective The loop diuretic bumetanide has been reported to potentiate the antiseizure activity of phenobarbital in rodent models of neonatal seizures,…”
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Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy by Schidlitzki, Alina, Bascuñana, Pablo, Srivastava, Prashant K., Welzel, Lisa, Twele, Friederike, Töllner, Kathrin, Käufer, Christopher, Gericke, Birthe, Feleke, Rahel, Meier, Martin, Polyak, Andras, Ross, Tobias L., Gerhauser, Ingo, Bankstahl, Jens P., Johnson, Michael R., Bankstahl, Marion, Löscher, Wolfgang

“…Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis…”
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Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures by Töllner, Kathrin, Twele, Friederike, Löscher, Wolfgang

“…Abstract Resistance to antiepileptic drugs (AEDs) is a major problem in epilepsy therapy, so that development of more effective AEDs is an unmet clinical need…”
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Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy by Hampel, Philip, Johne, Marie, Gailus, Björn, Vogel, Alexandra, Schidlitzki, Alina, Gericke, Birthe, Töllner, Kathrin, Theilmann, Wiebke, Käufer, Christopher, Römermann, Kerstin, Kaila, Kai, Löscher, Wolfgang

“…Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from…”
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Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy by Töpfer, Manuel, Töllner, Kathrin, Brandt, Claudia, Twele, Friederike, Bröer, Sonja, Löscher, Wolfgang

“…The diuretic bumetanide, which acts by blocking the Na–K–Cl cotransporter (NKCC), is widely used to inhibit neuronal NKCC1, particularly when NKCC1 expression…”
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Brain endothelial TAK1 and NEMO safeguard the neurovascular unit by Ridder, Dirk A, Wenzel, Jan, Müller, Kristin, Töllner, Kathrin, Tong, Xin-Kang, Assmann, Julian C, Stroobants, Stijn, Weber, Tobias, Niturad, Cristina, Fischer, Lisanne, Lembrich, Beate, Wolburg, Hartwig, Grand'Maison, Marilyn, Papadopoulos, Panayiota, Korpos, Eva, Truchetet, Francois, Rades, Dirk, Sorokin, Lydia M, Schmidt-Supprian, Marc, Bedell, Barry J, Pasparakis, Manolis, Balschun, Detlef, D'Hooge, Rudi, Löscher, Wolfgang, Hamel, Edith, Schwaninger, Markus

“…Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This…”
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Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter by Lykke, Kasper, Töllner, Kathrin, Römermann, Kerstin, Feit, Peter W, Erker, Thomas, MacAulay, Nanna, Löscher, Wolfgang

“…Background and Purpose The N‐K‐Cl cotransporters (NKCCs) mediate the coupled, electroneutral movement of Na+, K+ and Cl− ions across cell membranes. There are…”
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The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs by Löscher, Wolfgang, Hoffmann, Katrin, Twele, Friederike, Potschka, Heidrun, Töllner, Kathrin

“…Imepitoin potentiates GABAergic inhibition via the BZD site of the GABAA receptor but its affinity and intrinsic efficacy at this site are much lower compared…”
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Gene therapy decreases seizures in a model of Incontinentia pigmenti by Dogbevia, Godwin K., Töllner, Kathrin, Körbelin, Jakob, Bröer, Sonja, Ridder, Dirk A., Grasshoff, Hanna, Brandt, Claudia, Wenzel, Jan, Straub, Beate K., Trepel, Martin, Löscher, Wolfgang, Schwaninger, Markus

“…Objective Incontinentia pigmenti (IP) is a genetic disease leading to severe neurological symptoms, such as epileptic seizures, but no specific treatment is…”
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Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity by Kücker, Saskia, Töllner, Kathrin, Piechotta, Marion, Gernert, Manuela

“…Abstract Basal ganglia are engaged in seizure propagation, control of seizures, and in epilepsy-induced neuroplasticity. Here, we tested the hypothesis that…”
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Female Wistar rats obtained from different breeders vary in anxiety-like behavior and epileptogenesis by Honndorf, Stefanie, Lindemann, Christoph, Töllner, Kathrin, Gernert, Manuela

“…Summary Outbred rats are widely used in biomedical research studies. The genotypic variation, different housing and handling conditions during development, and…”
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Cerebral influx of Na + and Cl - as the osmotherapy-mediated rebound response in rats by Oernbo, Eva Kjer, Lykke, Kasper, Steffensen, Annette Buur, Töllner, Kathrin, Kruuse, Christina, Rath, Martin Fredensborg, Löscher, Wolfgang, MacAulay, Nanna

“…Cerebral edema can cause life-threatening increase in intracranial pressure. Besides surgical craniectomy performed in severe cases, osmotherapy may be…”
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A novel prodrug-based strategy to increase effects of bumetanide in epilepsy by Töllner, Kathrin, Brandt, Claudia, Töpfer, Manuel, Brunhofer, Gerda, Erker, Thomas, Gabriel, Mario, Feit, Peter W., Lindfors, Jenna, Kaila, Kai, Löscher, Wolfgang

“…Objective There is considerable interest in using bumetanide, a chloride importer Na‐K‐Cl cotransporter antagonist, for treatment of neurological diseases,…”
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Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus by Henke, Christine, Töllner, Kathrin, van Dijk, R. Maarten, Miljanovic, Nina, Cordes, Thekla, Twele, Friederike, Bröer, Sonja, Ziesak, Vanessa, Rohde, Marco, Hauck, Stefanie M., Vogel, Charlotte, Welzel, Lisa, Schumann, Tina, Willmes, Diana M., Kurzbach, Anica, El-Agroudy, Nermeen N., Bornstein, Stefan R., Schneider, Susanne A., Jordan, Jens, Potschka, Heidrun, Metallo, Christian M., Köhling, Rüdiger, Birkenfeld, Andreas L., Löscher, Wolfgang

“…In addition to tissues such as liver, the plasma membrane sodium-dependent citrate transporter, NaCT (SLC13A5), is highly expressed in brain neurons, but its…”
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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain by Römermann, Kerstin, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Töllner, Kathrin, Erker, Thomas, Sweet, Douglas H., Löscher, Wolfgang

“…There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including…”
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Network pharmacology for antiepileptogenesis: Tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus mice by Welzel, Lisa, Twele, Friederike, Schidlitzki, Alina, Töllner, Kathrin, Klein, Pavel, Löscher, Wolfgang

“…•Prevention of epilepsy in patients at risk is a major unmet clinical need.•Epilepsy is a network phenomenon, so its prevention may necessitate combinatorial…”
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