Search Results - "Tölle, Regine C."
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Three-Dimensional Cell Culture Conditions Affect the Proteome of Cancer-Associated Fibroblasts
Published in Journal of proteome research (03-08-2018)“…In vitro cell culture systems are an invaluable tool for cell biological research to study molecular pathways and to characterize processes critical in human…”
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A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Published in Nature communications (21-11-2016)“…Amino acids (aa) are not only building blocks for proteins, but also signalling molecules, with the mammalian target of rapamycin complex 1 (mTORC1) acting as…”
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Dietary spermidine improves cognitive function
Published in Cell reports (Cambridge) (13-04-2021)“…Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent…”
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Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders
Published in EBioMedicine (01-06-2019)“…Missense mutations in keratin 5 and 14 genes cause the severe skin fragility disorder epidermolysis bullosa simplex (EBS) by collapsing of the keratin…”
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Effects of the Extracellular Matrix on the Proteome of Primary Skin Fibroblasts
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…The cellular microenvironment often plays a crucial role in disease development and progression. In recessive dystrophic epidermolysis bullosa (RDEB),…”
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Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disordersResearch in context
Published in EBioMedicine (01-06-2019)“…Background: Missense mutations in keratin 5 and 14 genes cause the severe skin fragility disorder epidermolysis bullosa simplex (EBS) by collapsing of the…”
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