Search Results - "Tökés, Z A"

Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients by Lim, G P, Backstrom, J R, Cullen, M J, Miller, C A, Atkinson, R D, Tökés, Z A

“…Matrix metalloproteinases (MMPs) were analyzed by immunohistochemistry and zymography in amyotrophic lateral sclerosis (ALS) and control brain and spinal cord…”
Get more information

Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: identification of calcium-dependent metalloproteinases from the hippocampus by Backstrom, J R, Miller, C A, Tökés, Z A

“…Three neutral proteinases from human hippocampal tissue have been identified and partially characterized using substrate gel electrophoresis. The proteinases…”
Get more information

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-beta Peptide (1-40) by Backstrom, Jon R, Lim, Giselle P, Cullen, Michael J, Tokes, Zoltan A

“…We reported earlier that the levels of Ca2+-dependent metalloproteinases are increased in Alzheimer's disease (AD) specimens, relative to control specimens…”
Get full text

Matrix Metalloproteinases in Dog Brains Exhibiting Alzheimer‐Like Characteristics by Lim, Giselle P., Russell, Michael J., Cullen, Michael J., Tökés, Zoltán A.

“…: We have previously reported that the amount of the neuronal matrix metalloproteinase (MMP) MMP‐9, capable of cleaving β‐amyloid1–40 predominantly at…”
Get full text

Induction of erythroid differentiation in human leukemic K-562 cells by membrane-directed action of adriamycin covalently bound to microspheres by JEANNESSON, P, TRENTESAUX, C, GERARD, B, JARDILLIER, J.-C, ROSS, K. L, TOKES, Z. A

“…Covalent coupling of Adriamycin (ADR) to polyglutaraldehyde microspheres focuses the drug action to the plasma membrane which leads to growth inhibition and…”
Get full text

Creatine kinase BB: a new tumor-associated marker by Silverman, L M, Dermer, G B, Zweig, M H, Van Steirteghem, A C, Tökés, Z A

“…Creatine kinase isoenzyme BB (CK-BB) is found in the serum of patients with various types of cancer. Using both radioimmunoassay and agarose electrophoresis,…”
Get more information

The 84-kDa form of human matrix metalloproteinase-9 degrades substance P and gelatin by Backstrom, J R, Tökés, Z A

“…Matrix metalloproteinase-9 (MMP-9) is secreted from cells and, once activated, is thought to degrade collagen in the extracellular matrix. Because collagen is…”
Get more information

Immunohistochemical study of the expression of human milk fat globule membrane glycoprotein 70 by ASHRAF IMAM, TAYLOR, C. R, TOKES, Z. A

“…Human milk fat globule membrane, which is said to derive from apical plasma membrane of secretory epithelial cells in breast, was analyzed by sodium dodecyl…”
Get full text

Preferential expression of a Mr 155,000 milk-fat-globule membrane glycoprotein on luminal epithelium of lobules in human breast by IMAM, A, DRUSHELLA, M. M, TAYLOR, C. R, TOKES, Z. A

“…An integral membrane glycoprotein with an apparent molecular weight of 155,000 and isoelectric points ranging from 7.2 to 7.6 has been found to be…”
Get full text

Neurotoxicity and dermatotoxicity of cyanomorpholinyl adriamycin by CRAMER, S. C, RHODES, R. H, ACTON, E. M, TOKES, Z. A

“…The highly lipophilic cyanomorpholinyl adriamycin (CMA) is the most potent antineoplastic anthracycline yet described. CNS distribution and toxicity were…”
Get full text

Proteolytic activity associated with the nuclear scaffold. The effect of self-digestion on lamins by TOKES, Z. A, CLAWSON, G. A

“…The inner aspect of the nuclear envelope is supported by a peripheral framework called the nuclear scaffold, which consists of both structural and functional…”
Get full text

Liposome encapsulation enhancement of methotrexate sensitivity in a transport resistant human leukemic cell line by Todd, J A, Modest, E J, Rossow, P W, Tökés, Z A

“…A stable mutant of human leukemia CCRF/CEM cells has recently been isolated which is transport resistant for methotrexate (MTX). Encapsulation of MTX in…”
Get more information

Use of Anionic Liposomes for the Reduction of Chronic Doxorubicin-Induced Cardiotoxicity by Forssen, Eric A., Tokes, Zoltan A.

“…Anionic liposomes containing doxorubicin were evaluated in mice for therapeutic potential in reducing the risks of chronic cardiotoxicity characteristic of…”
Get full text

Synthesis of Adriamycin-Coupled Polyglutaraldehyde Microspheres and Evaluation of Their Cytostatic Activity by Tokes, Zoltan A., Rogers, Kathryn E., Rembaum, Alan

“…Adriamycin was coupled to polyglutaraldehyde microspheres having an average diameter of 4500 angstrom. The coupled microspheres remained stable during…”
Get full text

Novel mode of cytotoxicity obtained by coupling inactive anthracycline to a polymer by Rogers, K E, Tökés, Z A

“…The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog…”
Get more information

Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of 2-hydroxy-1H-isoindolediones as new cytostatic agents by Chan, Carcy L, Lien, Eric J, Tokes, Zoltan A

“…A series of 16 derivatives of 2-hydroxy-1H-isoindole-1,3-diones was designed and synthesized as potential antitumor agents. The cytostatic activity against…”
Get full text

The 46-kDa nucleoside triphosphatase of rat liver nuclear scaffold represents the N-terminal portion of lamins A/C by Clawson, G A, Lackey, A, Tokes, Z A

“…The major nucleoside triphosphatase (NTPase) of rat liver nuclear scaffold (NS) or envelope, which is thought to participate in nucleocytoplasmic transport,…”
Get more information

Phenotypic variations dictate the intracellular compartmentalization of doxorubicin in normal human bone marrow cells by AGHAÏ, E, TOKES, Z. A

“…In vitro accumulation of doxorubicin in intracellular compartments of normal bone marrow cells was studied with the use of fluorescent microscopy. Both the…”
Get full text

Proteolysis associated with normal, carcinogen-treated, and transformed rat liver epithelial cells by Tökés, Z A, Sorgente, N

“…A method was developed to distinguish between cell surface-associated and released proteolytic activity. The approach utilizes 125I-labeled protein substrate…”
Get more information

Generation and immunohistological characterization of human monoclonal antibodies to mammary carcinoma cells by Imam, A, Drushella, M M, Taylor, C R, Tökés, Z A

“…The purpose of this study was to identify human antibodies generated against autologous breast tumor cells by the host's immune response. Accordingly,…”
Get full text