Search Results - "Tóth, Péter T."

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis by Vadász, István, Dada, Laura A, Briva, Arturo, Trejo, Humberto E, Welch, Lynn C, Chen, Jiwang, Tóth, Péter T, Lecuona, Emilia, Witters, Lee A, Schumacker, Paul T, Chandel, Navdeep S, Seeger, Werner, Sznajder, Jacob I

“…Hypercapnia (elevated CO(2) levels) occurs as a consequence of poor alveolar ventilation and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase…”
Get full text

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice by Ilievski, Vladimir, Zuchowska, Paulina K, Green, Stefan J, Toth, Peter T, Ragozzino, Michael E, Le, Khuong, Aljewari, Haider W, O'Brien-Simpson, Neil M, Reynolds, Eric C, Watanabe, Keiko

“…The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease…”
Get full text

Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells by Zhang, Yanmin, Marsboom, Glenn, Toth, Peter T, Rehman, Jalees

“…Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated from bone marrow, adipose tissue as well as other tissues and have…”
Get full text

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation by Jambusaria, Ankit, Hong, Zhigang, Zhang, Lianghui, Srivastava, Shubhi, Jana, Arundhati, Toth, Peter T, Dai, Yang, Malik, Asrar B, Rehman, Jalees

“…Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression…”
Get full text

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer by Rehman, Jalees, Zhang, Hannah J., Toth, Peter T., Zhang, Yanmin, Marsboom, Glenn, Hong, Zhigang, Salgia, Ravi, Husain, Aliya N., Wietholt, Christian, Archer, Stephen L.

“…Mitochondria exist in dynamic networks that undergo fusion and fission. Mitochondrial fusion and fission are mediated by several GTPases in the outer…”
Get full text

Sox17 is required for endothelial regeneration following inflammation-induced vascular injury by Liu, Menglin, Zhang, Lianghui, Marsboom, Glenn, Jambusaria, Ankit, Xiong, Shiqin, Toth, Peter T., Benevolenskaya, Elizaveta V., Rehman, Jalees, Malik, Asrar B.

“…Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid homeostasis and normalizing leukocyte transmigration. However,…”
Get full text

Two-photon fluorescence and second harmonic generation characterization of extracellular matrix remodeling in post-injury murine temporomandibular joint osteoarthritis by Reed, David A, Yotsuya, Mamoru, Gubareva, Polina, Toth, Peter T, Bertagna, Andrew

“…End stage temporomandibular joint osteoarthritis (TMJ-OA) is characterized by fibrillations, fissures, clefts, and erosion of the mandibular condylar…”
Get full text

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension by Marsboom, Glenn, Toth, Peter T, Ryan, John J, Hong, Zhigang, Wu, Xichen, Fang, Yong-Hu, Thenappan, Thenappan, Piao, Lin, Zhang, Hannah J, Pogoriler, Jennifer, Chen, Yimei, Morrow, Erik, Weir, E Kenneth, Rehman, Jalees, Archer, Stephen L

“…RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery…”
Get full text

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence by Kim, Young-Mee, Youn, Seock-Won, Sudhahar, Varadarajan, Das, Archita, Chandhri, Reyhaan, Cuervo Grajal, Henar, Kweon, Junghun, Leanhart, Silvia, He, Lianying, Toth, Peter T., Kitajewski, Jan, Rehman, Jalees, Yoon, Yisang, Cho, Jaehyung, Fukai, Tohru, Ushio-Fukai, Masuko

“…Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial…”
Get full text

Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension by Piao, Lin, Fang, Yong-Hu, Parikh, Kishan, Ryan, John J., Toth, Peter T., Archer, Stephen L.

“…The rapid growth of cancer cells is permitted by metabolic changes, notably increased aerobic glycolysis and increased glutaminolysis. Aerobic glycolysis is…”
Get full text

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae by Zimnicka, Adriana M, Husain, Yawer S, Shajahan, Ayesha N, Sverdlov, Maria, Chaga, Oleg, Chen, Zhenlong, Toth, Peter T, Klomp, Jennifer, Karginov, Andrei V, Tiruppathi, Chinnaswamy, Malik, Asrar B, Minshall, Richard D

“…Caveolin 1 (Cav1) is a required structural component of caveolae, and its phosphorylation by Src is associated with an increase in caveolae-mediated…”
Get full text

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease by Jana, Arundhati, Wang, Xinge, Leasure, Joseph W., Magana, Lissette, Wang, Li, Kim, Young-Mee, Dodiya, Hemraj, Toth, Peter T., Sisodia, Sangram S., Rehman, Jalees

“…Blood–brain barrier (BBB) dysfunction is emerging as a key pathogenic factor in the progression of Alzheimer’s disease (AD), where increased microvascular…”
Get full text

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy by Jiang, Ying, Krantz, Sarah, Qin, Xiang, Li, Shun, Gunasekara, Hirushi, Kim, Young-Mee, Zimnicka, Adriana, Bae, Misuk, Ma, Ke, Toth, Peter T., Hu, Ying, Shajahan-Haq, Ayesha N., Patel, Hemal H., Gentile, Saverio, Bonini, Marcelo G., Rehman, Jalees, Liu, Yiyao, Minshall, Richard D.

“…As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular…”
Get full text

Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism by Srivastava, Shubhi, Gajwani, Priyanka, Jousma, Jordan, Miyamoto, Hiroe, Kwon, Youjeong, Jana, Arundhati, Toth, Peter T., Yan, Gege, Ong, Sang-Ging, Rehman, Jalees

“…Chemotherapy-induced cardiac damage remains a leading cause of death amongst cancer survivors. Anthracycline-induced cardiotoxicity is mediated by severe…”
Get full text

Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling by Kim, Young-Mee, Krantz, Sarah, Jambusaria, Ankit, Toth, Peter T., Moon, Hyung-Geun, Gunarathna, Isuru, Park, Gye Young, Rehman, Jalees

“…Endothelial barrier integrity is ensured by the stability of the adherens junction (AJ) complexes comprised of vascular endothelial (VE)-cadherin as well as…”
Get full text

Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle by Fang, Yong-Hu, Piao, Lin, Hong, Zhigang, Toth, Peter T., Marsboom, Glenn, Bache-Wiig, Peter, Rehman, Jalees, Archer, Stephen L.

“…Right ventricular hypertrophy (RVH) and RV failure are major determinants of prognosis in pulmonary hypertension and congenital heart disease. In RVH, there is…”
Get full text

Lung 18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension by MARSBOOM, Glenn, WIETHOLT, Christian, CHEN, Chin-Tu, ARCHER, Stephen L, HANEY, Chad R, TOTH, Peter T, RYAN, John J, MORROW, Erik, THENAPPAN, Thenappan, BACHE-WIIG, Peter, LIN PIAO, PAUL, Jonathan

“…Pulmonary arterial hypertension (PAH) is a proliferative arteriopathy associated with glucose transporter-1 (Glut1) up-regulation and a glycolytic shift in…”
Get full text

Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons by Jung, Hosung, Toth, Peter T, White, Fletcher A, Miller, Richard J

“…It has previously been observed that expression of chemokine monocyte chemoattractant protein-1 (MCP-1/CC chemokine ligand 2 (CCL2)) and its receptor CC…”
Get full text

Endosomal trafficking of two-pore K + efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury by Huang, Long Shuang, Anas, Mohammad, Xu, Jingsong, Zhou, Bisheng, Toth, Peter T, Krishnan, Yamuna, Di, Anke, Malik, Asrar B

“…Potassium efflux via the two-pore K channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K efflux is…”
Get full text

Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension by Rich, Stuart, Pogoriler, Jennifer, Husain, Aliya N, Toth, Peter T, Gomberg-Maitland, Mardi, Archer, Stephen L

“…The current treatment of pulmonary arterial hypertension (PAH) uses vasodilator drugs. Although they improve symptoms associated with PAH, their chronic…”
Get more information