Search Results - "Tóth, Orsolya M."
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Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery
Published in Biology (Basel, Switzerland) (11-12-2020)“…Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved challenge…”
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The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization
Published in British journal of pharmacology (01-05-2019)“…Background and Purpose A new class of dihydropyridine derivatives, which act as co‐inducers of heat shock protein but are devoid of calcium channel antagonist…”
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3
Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
Published in Scientific reports (25-04-2017)“…Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating…”
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Journal Article -
4
Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia
Published in Neuropharmacology (01-01-2020)“…Stroke is an important cause of mortality and disability. Treatment options are limited, therefore the progress in this regard is urgently needed. Nimodipine,…”
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Journal Article -
5
The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia
Published in Neurobiology of disease (01-04-2020)“…Spontaneous, recurrent spreading depolarizations (SD) are increasingly more appreciated as a pathomechanism behind ischemic brain injuries. Although the…”
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Journal Article -
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High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain
Published in Neurobiology of aging (01-12-2015)“…Abstract Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of…”
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Journal Article -
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Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex
Published in Neurocritical care (01-06-2022)“…Background In ischemic stroke, cerebral autoregulation and neurovascular coupling may become impaired. The cerebral blood flow (CBF) response to spreading…”
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Journal Article -
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Tissue Acidosis Associated with Ischemic Stroke to Guide Nimodipine Delivery
Published 01-01-2021“…Background: Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved…”
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Dissertation