Search Results - "Téllez, Jair"
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Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole
Published in Parasites & vectors (24-05-2019)“…Chagas disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Current therapeutic management is limited to…”
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Anti-SpCas9 IgY Polyclonal Antibodies Production for CRISPR Research Use
Published in ACS omega (19-09-2023)“…The CRISPR/Cas adaptative immune system has been harnessed as an RNA-guided, programmable genome editing tool, allowing for diverse biotechnological…”
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Transsulfuration is an active pathway for cysteine biosynthesis in Trypanosoma rangeli
Published in Parasites & vectors (24-04-2014)“…BACKGROUND: Cysteine, a sulfur-containing amino acid, plays an important role in a variety of cellular functions such as protein biosynthesis, methylation, and…”
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Viability and burden of Leishmania in extralesional sites during human dermal leishmaniasis
Published in PLoS neglected tropical diseases (14-09-2010)“…The clinical and epidemiological significance of Leishmania DNA in extralesional sites is obscured by uncertainty of whether the DNA derives from viable…”
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Prediction of potential cysteine synthase inhibitors of Leishmania braziliensis and Leishmania major parasites by computational screening
Published in Acta tropica (01-01-2022)“…•Virtual screening allowed us to predict potential new CS inhibitors for Leishmania parasites.•The ZINC16524774 compound predicted to have a high affinity for…”
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Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress
Published in Antimicrobial agents and chemotherapy (01-08-2015)“…Cysteine metabolism is considered essential for the crucial maintenance of a reducing environment in trypanosomatids due to its importance as a precursor of…”
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Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages
Published in Antimicrobial agents and chemotherapy (01-07-2017)“…Leishmaniasis is a neglected tropical disease that affects millions of people worldwide and represents a major public health problem. Information on protein…”
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Use of liposomal nanoformulations in antileishmania therapy: challenges and perspectives
Published in Journal of liposome research (03-04-2021)“…Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries,…”
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Lupeol acetate and alpha-amyrin terpenes activity against 'Trypanosoma cruzi': Insights into toxicity and potential mechanisms of action
Published in Tropical medicine and infectious disease (03-05-2023)“…Background: Chagas disease is a potentially fatal disease caused by the parasite 'Trypanosoma cruzi'. There is growing scientific interest in finding new and…”
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Detection of Leishmania in Unaffected Mucosal Tissues of Patients with Cutaneous Leishmaniasis Caused by Leishmania (Viannia) Species
Published in The Journal of infectious diseases (15-08-2009)“…BackgroundLeishmania (Viannia) species are the principal cause of mucosal leishmaniasis. The natural history and pathogenesis of mucosal disease are enigmatic…”
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Nanoencapsulamiento como estrategia para mejorar la entrega de medicamentos para el tratamiento de enfermedades infecciosas: una visión general
Published in Revista Colombiana de biotecnologia (31-01-2022)“…El control quimioterapéutico es una de las principales formas de combatir las enfermedades infecciosas, sin embargo, existen varias limitaciones que ponen en…”
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Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response
Published in PLoS neglected tropical diseases (01-10-2012)“…Previous findings indicate that susceptibility to Leishmania (Viannia) panamensis infection of monocyte-derived macrophages from patients and asymptomatically…”
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Biological characterization of Trypanosoma cruzi stocks from domestic and sylvatic vectors in Sierra Nevada of Santa Marta, Colombia
Published in Acta tropica (01-10-2008)“…Sierra Nevada of Santa Marta is one of the most endemic regions of Chagas disease in Colombia. In this study, we compared the biological behavior and genetic…”
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Lupeol Acetate and α-Amyrin Terpenes Activity against ITrypanosoma cruzi/I: Insights into Toxicity and Potential Mechanisms of Action
Published in Tropical medicine and infectious disease (01-05-2023)“…Background: Chagas disease is a potentially fatal disease caused by the parasite Trypanosoma cruzi. There is growing scientific interest in finding new and…”
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