Search Results - "T, Prabhakar B"

Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations by G, Prakasha, Revanasiddappa, H D, B, Jayalakshmi, T, Prabhakar B, Shivamallu, Chandan, Viswanath, Prashant M, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Manturova, Natalia, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Armaković, Sanja J, Armaković, Stevan, Kollur, Shiva Prasad

“…The emerging interest in the field of coordination chemistry and their biological applications has created a novel impact in the field of chemical biology…”
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The tumor antagonistic steroidal alkaloid Solanidine prompts the intrinsic suicidal signal mediated DFF-40 nuclear import and nucleosomal disruption by Malojirao, Vikas H., Vigneshwaran, V., Thirusangu, Prabhu, Mahmood, Riaz, Prabhakar, B.T.

“…Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these…”
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Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast by Shivakumar, S, Prabhakar, B. T, Jayashree, K, Rajan, M. G. R, Salimath, Bharathi P

“…Purpose Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide. A great deal of interest has been paid to the predictive value of…”
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Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells by Prabhakar, B.T., Khanum, Shaukath Ara, Jayashree, K., Salimath, Bharathi P., Shashikanth, S.

“…A series of substituted benzophenone analogues, (2-aroyl-4-methylphenoxy)acetamides 4a– e, have been synthesized via the three-step synthesis sequence…”
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Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression by Al-Ostoot, Fares Hezam, Sherapura, Ankith, V, Vigneshwaran, Basappa, Giridhara, H K, Vivek, B T, Prabhakar, Khanum, Shaukath Ara

“…Hypoxic microenvironment is a common feature of solid tumors, which leads to the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic…”
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Fabrication of Antheraea mylitta sericin hydrogel film via non toxic crosslinking citric acid with antioxidant properties by Khanapure, Sheela, Sherapura, Ankith, T, Prabhakar B, Vootla, Shyam Kumar

“…Sericin, a water-soluble protein biopolymer, is usually discarded as a byproduct of the silk processing industries. However, in recent years the applications…”
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The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death by Mohammed, Yasser Hussein Eissa, Malojirao, Vikas H., Thirusangu, Prabhu, Al-Ghorbani, Mohammed, Prabhakar, B.T., Khanum, Shaukath Ara

“…Tumor microenvironment is a complex multistep event which involves several hallmarks that transform the normal cell into cancerous cell. Designing the novel…”
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Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis by Vijay Avin, B.R., Thirusangu, Prabhu, Lakshmi Ranganatha, V., Firdouse, Aiyesha, Prabhakar, B.T., Khanum, Shaukath Ara

“…A sequence of coumarin analogs 5a–j was obtained by multi step synthesis from hydroxy benzophenones (1a–j). The in vitro antiproliferative effect of the title…”
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Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma by Sherapura, Ankith, Siddesh, B.M., Malojirao, Vikas H., Thirusangu, Prabhu, Avin, B.R. Vijay, Kumari, N Suchetha, Ramachandra, Y.L., Prabhakar, B.T.

“…•TME perseveres complex interwoven signaling nexus of inflammatory hypoxia and DDR pathways.•Hypoxia driven ATM/HIF-1α phosphorylation promotes tumor…”
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The anti-invasive role of novel synthesized pyridazine hydrazide appended phenoxy acetic acid against neoplastic development targeting matrix metallo proteases by Eissa Mohammed, Yasser Hussein, Thirusangu, Prabhu, Zabiulla, V, Vigneshwaran, B.T, Prabhakar, Khanum, Shaukath Ara

“…[Display omitted] Neoplastic metastasis is a major process where tumor cells migrate from the primary tumor and colonize at other parts of our body to form…”
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Synthesis and amelioration of inflammatory paw edema by novel benzophenone appended oxadiazole derivatives by exhibiting cyclooxygenase-2 antagonist activity by Puttaswamy, Naveen, Malojiao, Vikas H., Mohammed, Yasser Hussein Eissa, Sherapura, Ankith, Prabhakar, B.T., Khanum, Shaukath Ara

“…[Display omitted] •Synthesis of benzophenone fused oxadiazole analogues 10a–j by acid amine coupling.•Compounds 10a–j were subjected for HRBC membrane…”
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Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma by Prashanth, T., Avin, B.R. Vijay, Thirusangu, Prabhu, Ranganatha, V. Lakshmi, Prabhakar, B.T., Sharath Chandra, J.N. Narendra, Khanum, Shaukath Ara

“…[Display omitted] •Novel coumarin analogs were synthesized with verity of substituents.•Docking studies have been done for the potent compound 13f.•In vitro…”
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Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour by Banumathi, Sherapura, Ankith, Malojirao, Vikas H, Zabiulla, Sharath, B S, Thirusangu, Prabhu, Mahmood, Riaz, Kumari, N Suchetha, Baliga, Shrinath M, Khanum, Shaukath Ara, Prabhakar, B T

“…Anomalous activation of intra-cellular signalling cascades confers neoplastic properties on malignant cells. The JAK2/STAT3 proteins play a pivotal role in the…”
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A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression by Thirusangu, Prabhu, Vigneshwaran, V., Ranganatha, V. Lakshmi, Vijay Avin, B.R., Khanum, Shaukath Ara, Mahmood, Riaz, Jayashree, K., Prabhakar, B.T.

“…[Display omitted] Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and metastasis. Stabilization and subsequent nuclear…”
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Matrix‐Metalloproteinase Inhibitory Study of Novel Tetrahydroisoquinoline‐4‐carboxylates: Design, Synthesis, and Molecular Docking Studies by Devappa Satyanarayan, Nayak, Kammathalli Siddappa, Manjunatha, Rahman, Abdul, Belur Ningegowda, Nippu, Sherapura, Ankith, Siddesh, B. M., Prabhakar, B. T.

“…The design, molecular docking, synthesis and structure‐activity relationship (SAR) of a series of novel methyl…”
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The latex sap of the ‘Old World Plant’ Lagenaria siceraria with potent lectin activity mitigates neoplastic malignancy targeting neovasculature and cell death by Vigneshwaran, V., Thirusangu, Prabhu, Madhusudana, S., Krishna, V., Pramod, Siddanakoppalu N., Prabhakar, B.T.

“…Lifestyle and dietary modifications have contributed much to somatic genetic alteration which has concomitantly led to increase in malignant diseases…”
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Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia by Al-Ostoot, Fares Hezam, Sherapura, Ankith, Malojirao, Vikas H, Thirusangu, Prabhu, Al-Muhimeed, Tahani I, Khanum, Shaukath Ara, Prabhakar, B T

“…Imbalance and instability in the structure of the DNA have become major characteristics of cancer. In response to DNA damage, DNA damage response (DDR)…”
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Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation by Thirusangu, Prabhu, Vigneshwaran, V., Vijay Avin, B.R., Rakesh, H., Vikas, H.M., Prabhakar, B.T.

“…Neoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery…”
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Immunomodulatory glc/man‐directed Dolichos lablab lectin (DLL) evokes anti‐tumour response in vivo by counteracting angiogenic gene expressions by Vigneshwaran, V., Thirusangu, P., Vijay Avin, B. R., Krishna, V., Pramod, S. N., Prabhakar, B. T.

“…Summary Neovascularization and jeopardized immunity has been critically emphasized for the establishment of malignant progression. Lectins are the diverse…”
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Synthesis and evaluation of novel benzophenone-thiazole derivatives as potent VEGF-A inhibitors by Prashanth, T., Thirusangu, Prabhu, Vijay Avin, B.R., Lakshmi Ranganatha, V., Prabhakar, B.T., Khanum, Shaukath Ara

“…A series of 2-(4-benzoyl-phenoxy)-N-(4-phenyl-thiazol-2-yl)-acetamides (10a–n) were synthesized by multistep reaction sequence and all the compounds were well…”
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