Search Results - "Szyndralewiez, Cédric"

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis by Laleu, Benoı̂t, Gaggini, Francesca, Orchard, Mike, Fioraso-Cartier, Laetitia, Cagnon, Laurène, Houngninou-Molango, Sophie, Gradia, Angelo, Duboux, Guillaume, Merlot, Cédric, Heitz, Freddy, Szyndralewiez, Cédric, Page, Patrick

“…We describe the design, synthesis, and optimization of first-in-class series of inhibitors of NADPH oxidase isoform 4 (Nox4), an enzyme implicated in several…”
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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo by Jiang, Joy X., Chen, Xiangling, Serizawa, Nobuko, Szyndralewiez, Cédric, Page, Patrick, Schröder, Katrin, Brandes, Ralf P., Devaraj, Sridevi, Török, Natalie J.

“…Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Homologs of NADPH oxidases (NOXs) are major sources of ROS, but the exact…”
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Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes by Gorin, Yves, Cavaglieri, Rita C, Khazim, Khaled, Lee, Doug-Yoon, Bruno, Francesca, Thakur, Sachin, Fanti, Paolo, Szyndralewiez, Cédric, Barnes, Jeffrey L, Block, Karen, Abboud, Hanna E

“…Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role in the pathogenesis of diabetic nephropathy (DN). The efficacy of the…”
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Pre‐clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis by Thannickal, Victor J., Jandeleit‐Dahm, Karin, Szyndralewiez, Cédric, Török, Natalie J.

“…Fibrosis describes a dysregulated tissue remodelling response to persistent cellular injury and is the final pathological consequence of many chronic diseases…”
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The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation by Green, David E, Murphy, Tamara C, Kang, Bum-Yong, Kleinhenz, Jennifer M, Szyndralewiez, Cédric, Page, Patrick, Sutliff, Roy L, Hart, C Michael

“…Increased NADP reduced (NADPH) oxidase 4 (Nox4) and reduced expression of the nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ)…”
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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent by Aoyama, Tomonori, Paik, Yong-Han, Watanabe, Sumio, Laleu, Benoît, Gaggini, Francesca, Fioraso-Cartier, Laetitia, Molango, Sophie, Heitz, Freddy, Merlot, Cédric, Szyndralewiez, Cédric, Page, Patrick, Brenner, David A.

“…Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) generates reactive oxygen species (ROS) in hepatic stellate cells (HSCs) during liver…”
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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism by Garrido-Urbani, Sarah, Jemelin, Stephane, Deffert, Christine, Carnesecchi, Stéphanie, Basset, Olivier, Szyndralewiez, Cédric, Heitz, Freddy, Page, Patrick, Montet, Xavier, Michalik, Liliane, Arbiser, Jack, Rüegg, Curzio, Krause, Karl Heinz, Imhof, Beat A, Imhof, Beat

“…Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different…”
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Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD by Hollins, Fay, Sutcliffe, Amanda, Gomez, Edith, Berair, Rachid, Russell, Richard, Szyndralewiez, Cédric, Saunders, Ruth, Brightling, Christopher

“…The burden of oxidative stress is increased in chronic obstructive pulmonary disease (COPD). However, whether the intra-cellular mechanisms controlling the…”
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NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma by Wan, Wing-Yan Heidi, PhD, Hollins, Fay, PhD, Haste, Louise, PhD, Woodman, Lucy, PhD, Hirst, Robert A., PhD, Bolton, Sarah, PhD, Gomez, Edith, PhD, Sutcliffe, Amanda, PhD, Desai, Dhananjay, PhD, Chachi, Latifa, PhD, Mistry, Vijay, BSc, Szyndralewiez, Cédric, PhD, Wardlaw, Andrew, PhD, Saunders, Ruth, PhD, O’Callaghan, Christopher, PhD, Andrew, Peter W., PhD, Brightling, Christopher E., PhD, FCCP

“…Background Bronchial epithelial ciliary dysfunction is an important feature of asthma. We sought to determine the role in asthma of neutrophilic inflammation…”
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Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice by Eid, Stéphanie A, El Massry, Mohamed, Hichor, Mehdi, Haddad, Mary, Grenier, Julien, Dia, Batoul, Barakat, Rasha, Boutary, Suzan, Chanal, Johan, Aractingi, Selim, Wiesel, Philippe, Szyndralewiez, Cédric, Azar, Sami T, Boitard, Christian, Zaatari, Ghazi, Eid, Assaad A, Massaad, Charbel

“…Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This…”
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NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy by Wilkinson-Berka, Jennifer L, Deliyanti, Devy, Rana, Indrajeetsinh, Miller, Antonia G, Agrotis, Alex, Armani, Roksana, Szyndralewiez, Cédric, Wingler, Kirstin, Touyz, Rhian M, Cooper, Mark E, Jandeleit-Dahm, Karin A, Schmidt, Harald H H W

“…Ischemic retinal diseases such as retinopathy of prematurity are major causes of blindness due to damage to the retinal microvasculature. Despite this clinical…”
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Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors by Gaggini, Francesca, Laleu, Benoît, Orchard, Mike, Fioraso-Cartier, Laetitia, Cagnon, Laurène, Houngninou-Molango, Sophie, Gradia, Angelo, Duboux, Guillaume, Merlot, Cédric, Heitz, Freddy, Szyndralewiez, Cédric, Page, Patrick

“…Pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives are new chemical entities with good and attractive druglikeness properties. A series of…”
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NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis by Vendrov, Aleksandr E., Madamanchi, Nageswara R., Niu, Xi-Lin, Molnar, Kimberly C., Runge, Mason, Szyndralewiez, Cédric, Page, Patrick, Runge, Marschall S.

“…The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle cell (VSMC) function and…”
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Nox4 is a Target for Tuberin Deficiency Syndrome by Shi, Qian, Viswanadhapalli, Suryavathi, Friedrichs, William E., Velagapudi, Chakradhar, Szyndralewiez, Cédric, Bansal, Shweta, Bhat, Manzoor A., Choudhury, Goutam Ghosh, Abboud, Hanna E.

“…The mechanism by which TSC2 inactivation or deficiency contributes to the pathology of tuberous sclerosis complex (TSC) is not fully clear. We show that renal…”
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Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor-based immunotherapy by Stalin, Jimmy, Garrido-Urbani, Sarah, Heitz, Freddy, Szyndralewiez, Cédric, Jemelin, Stephane, Coquoz, Oriana, Ruegg, Curzio, Imhof, Beat A

“…NADPH oxidases catalyze the production of reactive oxygen species and are involved in physio/pathological processes. NOX1 is highly expressed in colon cancer…”
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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy by JHA, Jay C, GRAY, Stephen P, TOUYZ, Rhian M, COOPER, Mark E, SCHMIDT, Harald H. H. W, JANDELEIT-DAHM, Karin A, BARIT, David, OKABE, Jun, EL-OSTA, Assam, NAMIKOSHI, Tamehachi, THALLAS-BONKE, Vicki, WINGLER, Kirstin, SZYNDRALEWIEZ, Cedric, HERTZ, Freddy

“…Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species…”
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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4 by Hanley, Christopher J, Mellone, Massimiliano, Ford, Kirsty, Thirdborough, Steve M, Mellows, Toby, Frampton, Steven J, Smith, David M, Harden, Elena, Szyndralewiez, Cedric, Bullock, Marc, Noble, Fergus, Moutasim, Karwan A, King, Emma V, Vijayanand, Pandurangan, Mirnezami, Alex H, Underwood, Timothy J, Ottensmeier, Christian H, Thomas, Gareth J

“…Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential…”
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NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis by Gray, Stephen P, Di Marco, Elyse, Okabe, Jun, Szyndralewiez, Cedric, Heitz, Freddy, Montezano, Augusto C, de Haan, Judy B, Koulis, Christine, El-Osta, Assam, Andrews, Karen L, Chin-Dusting, Jaye P F, Touyz, Rhian M, Wingler, Kirstin, Cooper, Mark E, Schmidt, Harald H. H W, Jandeleit-Dahm, Karin A

“…BACKGROUND—In diabetes mellitus, vascular complications such as atherosclerosis are a major cause of death. The key underlying pathomechanisms are unclear…”
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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes by Sedeek, Mona, Gutsol, Alex, Montezano, Augusto C, Burger, Dylan, Nguyen Dinh Cat, Aurelie, Kennedy, Chris R J, Burns, Kevin D, Cooper, Mark E, Jandeleit-Dahm, Karin, Page, Patrick, Szyndralewiez, Cedric, Heitz, Freddy, Hebert, Richard L, Touyz, Rhian M

“…Nox (NADPH oxidase)-derived ROS (reactive oxygen species) have been implicated in the development of diabetic nephropathy. Of the Nox isoforms in the kidney,…”
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NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis by Di Marco, Elyse, Gray, Stephen P., Kennedy, Kit, Szyndralewiez, Cedric, Lyle, Alicia N., Lassègue, Bernard, Griendling, Kathy K., Cooper, Mark E., Schmidt, Harald H.H.W., Jandeleit-Dahm, Karin A.M.

“…Smooth muscle cell (SMC) proliferation and fibrosis contribute to the development of advanced atherosclerotic lesions. Oxidative stress caused by increased…”
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