Search Results - "Szweda, Luke I"

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition by Hirose, Kentaro, Payumo, Alexander Y, Cutie, Stephen, Hoang, Alison, Zhang, Hao, Guyot, Romain, Lunn, Dominic, Bigley, Rachel B, Yu, Hongyao, Wang, Jiajia, Smith, Megan, Gillett, Ellen, Muroy, Sandra E, Schmid, Tobias, Wilson, Emily, Field, Kenneth A, Reeder, DeeAnn M, Maden, Malcom, Yartsev, Michael M, Wolfgang, Michael J, Grützner, Frank, Scanlan, Thomas S, Szweda, Luke I, Buffenstein, Rochelle, Hu, Guang, Flamant, Frederic, Olgin, Jeffrey E, Huang, Guo N

“…Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian…”
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The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response by Puente, Bao N., Kimura, Wataru, Muralidhar, Shalini A., Moon, Jesung, Amatruda, James F., Phelps, Kate L., Grinsfelder, David, Rothermel, Beverly A., Chen, Rui, Garcia, Joseph A., Santos, Celio X., Thet, SuWannee, Mori, Eiichiro, Kinter, Michael T., Rindler, Paul M., Zacchigna, Serena, Mukherjee, Shibani, Chen, David J., Mahmoud, Ahmed I., Giacca, Mauro, Rabinovitch, Peter S., Asaithamby, Aroumougame, Shah, Ajay M., Szweda, Luke I., Sadek, Hesham A.

“…The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit…”
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Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability by Crewe, Clair, Schafer, Christopher, Lee, Irene, Kinter, Michael, Szweda, Luke I.

“…Cardiac metabolic inflexibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylation-dependent inhibition of…”
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High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria by Rindler, Paul M., Plafker, Scott M., Szweda, Luke I., Kinter, Michael

“…Obesity is a predictor of diabetes and cardiovascular disease. One consequence of obesity is dyslipidemia characterized by high blood triglycerides. It has…”
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MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation by Makarewich, Catherine A., Baskin, Kedryn K., Munir, Amir Z., Bezprozvannaya, Svetlana, Sharma, Gaurav, Khemtong, Chalermchai, Shah, Akansha M., McAnally, John R., Malloy, Craig R., Szweda, Luke I., Bassel-Duby, Rhonda, Olson, Eric N.

“…Micropeptide regulator of β-oxidation (MOXI) is a conserved muscle-enriched protein encoded by an RNA transcript misannotated as non-coding. MOXI localizes to…”
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Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue by Joffin, Nolwenn, Paschoal, Vivian A., Gliniak, Christy M., Crewe, Clair, Elnwasany, Abdallah, Szweda, Luke I., Zhang, Qianbin, Hepler, Chelsea, Kusminski, Christine M., Gordillo, Ruth, Oh, Da Young, Gupta, Rana K., Scherer, Philipp E.

“…The adipose tissue stroma is a rich source of molecularly distinct stem and progenitor cell populations with diverse functions in metabolic regulation,…”
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Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts by ALLEN, Bryan G, BHATIA, Sudershan K, BUATTI, John M, BRANDT, Kristin E, LINDHOLM, Kaleigh E, BUTTON, Anna M, SZWEDA, Luke I, SMITH, Brian J, SPITZ, Douglas R, FATH, Melissa A

“…Ketogenic diets are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather…”
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The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice by Makarewich, Catherine A, Munir, Amir Z, Bezprozvannaya, Svetlana, Gibson, Aaron M, Young Kim, Soo, Martin-Sandoval, Misty S, Mathews, Thomas P, Szweda, Luke I, Bassel-Duby, Rhonda, Olson, Eric N

“…Emerging evidence indicates that a subset of RNA molecules annotated as noncoding contain short open reading frames that code for small functional proteins…”
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Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart by Crewe, Clair, Kinter, Michael, Szweda, Luke I

“…Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate…”
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Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials by Zahra, Amir, Fath, Melissa A., Opat, Emyleigh, Mapuskar, Kranti A., Bhatia, Sudershan K., Ma, Daniel C., III, Samuel N. Rodman, Snyders, Travis P., Chenard, Catherine A., Eichenberger-Gilmore, Julie M., Bodeker, Kellie L., Ahmann, Logan, Smith, Brian J., Vollstedt, Sandy A., Brown, Heather A., Hejleh, Taher Abu, Clamon, Gerald H., Berg, Daniel J., Szweda, Luke I., Spitz, Douglas R., Buatti, John M., Allen, Bryan G.

“…Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy…”
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High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice by Peri-Okonny, Poghni, Baskin, Kedryn K, Iwamoto, Gary, Mitchell, Jere H, Smith, Scott A, Kim, Han Kyul, Szweda, Luke I, Bassel-Duby, Rhonda, Fujikawa, Teppei, Castorena, Carlos M, Richardson, James, Shelton, John M, Ayers, Colby, Berry, Jarett D, Malladi, Venkat S, Hu, Ming-Chang, Moe, Orson W, Scherer, Philipp E, Vongpatanasin, Wanpen

“…BACKGROUND:Inorganic phosphate (Pi) is used extensively as a preservative and a flavor enhancer in the Western diet. Physical inactivity, a common feature of…”
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Mechanisms for Countering Oxidative Stress and Damage in Retinal Pigment Epithelium by Plafker, Scott M., O'Mealey, Gary B., Szweda, Luke I.

“…Clinical and experimental evidence supports that chronic oxidative stress is a primary contributing factor to numerous retinal degenerative diseases, such as…”
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes by Logan, Sreemathi, Pharaoh, Gavin A., Marlin, M. Caleb, Masser, Dustin R., Matsuzaki, Satoshi, Wronowski, Benjamin, Yeganeh, Alexander, Parks, Eileen E., Premkumar, Pavithra, Farley, Julie A., Owen, Daniel B., Humphries, Kenneth M., Kinter, Michael, Freeman, Willard M., Szweda, Luke I., Van Remmen, Holly, Sonntag, William E.

“…A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age,…”
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Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria by Rindler, Paul M, Crewe, Clair L, Fernandes, Jolyn, Kinter, Michael, Szweda, Luke I

“…Obesity enhances the risk for the development of type 2 diabetes and cardiovascular disease. Loss in insulin sensitivity and diminished ability of muscle to…”
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Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity by Bulteau, Anne-Laure, O'Neill, Heather A., Kennedy, Mary Claire, Ikeda-Saito, Masao, Isaya, Grazia, Szweda, Luke I.

“…Numerous degenerative disorders are associated with elevated levels of pro-oxidants and declines in mitochondrial aconitase activity. Deficiency in the…”
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Oxidative modification of lipoic acid by HNE in Alzheimer disease brain by Hardas, Sarita S, Sultana, Rukhsana, Clark, Amy M, Beckett, Tina L, Szweda, Luke I, Murphy, M Paul, Butterfield, D Allan

“…Alzheimer disease (AD) is an age-related neurodegenerative disease characterized by the presence of three pathological hallmarks: synapse loss, extracellular…”
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PPARα is essential for retinal lipid metabolism and neuronal survival by Pearsall, Elizabeth A, Cheng, Rui, Zhou, Kelu, Takahashi, Yusuke, Matlock, H Greg, Vadvalkar, Shraddha S, Shin, Younghwa, Fredrick, Thomas W, Gantner, Marin L, Meng, Steven, Fu, Zhongjie, Gong, Yan, Kinter, Michael, Humphries, Kenneth M, Szweda, Luke I, Smith, Lois E H, Ma, Jian-Xing

“…Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal…”
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Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes by Farout, Luc, Mary, Jean, Vinh, Joëlle, Szweda, Luke I., Friguet, Bertrand

“…The proteasome represents a major intracellular proteolytic system responsible for the degradation of oxidized and ubiquitinated proteins in both the nucleus…”
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Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy by Elnwasany, Abdallah, Ewida, Heba A, Szweda, Pamela A, Szweda, Luke I

“…Obesity affects a growing fraction of the population and is a risk factor for type 2 diabetes and cardiovascular disease. Even in the absence of hypertension…”
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Mitochondrial protein oxidation and degradation in response to oxidative stress and aging by Bulteau, Anne-Laure, Szweda, Luke I., Friguet, Bertrand

“…Mitochondria are a major source of intracellular reactive oxygen species (ROS), the production of which increases with age. These organelles are also targets…”
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