Search Results - "Szurszewski, JH"

Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS by Linden, DR, Furne, J, Stoltz, GJ, Abdel‐Rehim, MS, Levitt, MD, Szurszewski, JH

“…BACKGROUND AND PURPOSE Hydrogen sulphide (H2S) is gaining acceptance as a gaseous signal molecule. However, mechanisms regarding signal termination are not…”
Get full text

Modulation by opioid peptides of mechanosensory pathways supplying the guinea-pig inferior mesenteric ganglion by Ma, R C, Szurszewski, J H

“…1. Radioimmunological techniques were used in isolated guinea-pig inferior mesenteric ganglion (IMG)-colon preparations to determine whether opioid peptides…”
Get full text

Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion by Ma, R.C., Szurszewski, J.H.

“…Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether…”
Get full text

Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation by Lyford, G L, He, C-L, Soffer, E, Hull, T L, Strong, S A, Senagore, A J, Burgart, L J, Young-Fadok, T, Szurszewski, J H, Farrugia, G

“…Background: Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the…”
Get full text

Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes by He, C-Liang, Szurszewski, Joseph H., Farrugia, Gianrico, Soffer, Edy E., Walsh, R.Matthew, Ferris, Christopher D.

“…Background & Aims: Gastrointestinal complications of long-standing diabetes include nausea, vomiting, abdominal pain, diarrhea, and constipation.The…”
Get full text

Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease by Lennon, V A, Ermilov, L G, Szurszewski, J H, Vernino, S

“…Neuronal nicotinic AChRs (nAChRs) are implicated in the pathogenesis of diverse neurological disorders and in the regulation of small-cell lung carcinoma…”
Get full text

Passive Transfer of Autoimmune Autonomic Neuropathy to Mice by Vernino, Steven, Ermilov, Leonid G, Sha, Lei, Szurszewski, Joseph H, Low, Phillip A, Lennon, Vanda A

“…Autoimmune autonomic neuropathy (AAN) is an acquired, often severe, form of dysautonomia. Many patients with AAN have serum antibodies specific for the…”
Get full text

Sodium current in human intestinal interstitial cells of Cajal by Strege, Peter R, Ou, Yijun, Sha, Lei, Rich, Adam, Gibbons, Simon J, Szurszewski, Joseph H, Sarr, Michael G, Farrugia, Gianrico

“…Interstitial cells of Cajal (ICC) generate the electrical slow wave required for normal gastrointestinal motility. The ionic conductances expressed in human…”
Get more information

Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide by Choi, K. M., Gibbons, S. J., Roeder, J. L., Lurken, M. S., Zhu, J., Wouters, M. M., Miller, S. M., Szurszewski, J. H., Farrugia, G.

“…The factors underlying the survival and maintenance of interstitial cells of Cajal (ICC) are not well understood. Loss of ICC is often associated with loss of…”
Get full text

Neurotensin facilitates release of substance P in the guinea-pig inferior mesenteric ganglion by Stapelfeldt, W H, Szurszewski, J H

“…1. Intracellular, electrophysiological techniques were combined with radio-immunological, chromatographic and pharmacological techniques to determine if nerve…”
Get full text

Carbon Monoxide and Nitric Oxide as Coneurotransmitters in the Enteric Nervous System: Evidence from Genomic Deletion of Biosynthetic Enzymes by Xue, L., Farrugia, G., Miller, S. M., Ferris, C. D., Snyder, S. H., Szurszewski, J. H.

“…Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters in the brain. The colocalization of their respective biosynthetic enzymes, neuronal NO…”
Get full text

Apoptotic cell death of human interstitial cells of Cajal by Gibbons, S. J., De Giorgio, R., Faussone Pellegrini, M. S., Garrity‐park, M. M., Miller, S. M., Schmalz, P. F., Young‐fadok, T. M., Larson, D. W., Dozois, E. J., Camilleri, M., Stanghellini, V., Szurszewski, J. H., Farrugia, G.

“…Interstitial cells of Cajal (ICC) are specialized mesenchyme‐derived cells that regulate contractility and excitability of many smooth muscles with loss of ICC…”
Get full text

Chronic Intestinal Pseudoobstruction Associated With Altered Interstitial Cells of Cajal Networks by Feldstein, Ariel E., Miller, Steven M., El-Youssef, Mounif, Rodeberg, David, Lindor, Noralane M., Burgart, Lawrence J., Szurszewski, Joseph H., Farrugia, Gianrico

Get full text

A Major Role for Carbon Monoxide as an Endogenous Hyperpolarizing Factor in the Gastrointestinal Tract by Farrugia, Gianrico, Lei, Sha, Lin, Xue, Miller, Steven M., Nath, Karl A., Ferris, Christopher D., Levitt, Michael, Szurszewski, Joseph H.

“…Carbon monoxide (CO) is proposed as a physiological messenger. CO activates cGMP and has a direct effect on potassium channels. Both actions of CO lead to…”
Get full text

alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation by Lyford, Greg L, Strege, Peter R, Shepard, Allan, Ou, Yijun, Ermilov, Leonid, Miller, Steven M, Gibbons, Simon J, Rae, James L, Szurszewski, Joseph H, Farrugia, Gianrico

“…Smooth muscle exhibits mechanosensitivity independent of neural input, suggesting that mechanosensitive pathways reside within smooth muscle cells. The native…”
Get more information

Role of nitric oxide in gastrointestinal and hepatic function and disease by Stark, M E, Szurszewski, J H

Get more information

Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture by Rich, Adam, Miller, Steven M, Gibbons, Simon J, Malysz, John, Szurszewski, Joseph H, Farrugia, G

“…The binding of Steel factor (SF) to c-kit initiates a signaling pathway essential for development and maintenance of interstitial cells of Cajal (ICC). Soluble…”
Get more information

Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism by Lim, Inja, Gibbons, Simon J, Lyford, Gregory L, Miller, Steven M, Strege, Peter R, Sarr, Michael G, Chatterjee, Suvro, Szurszewski, Joseph H, Shah, Vijay H, Farrugia, Gianrico

“…Carbon monoxide (CO) is increasingly recognized as a physiological messenger. CO is produced in the gastrointestinal tract with diverse functions, including…”
Get more information

Circumferential, not longitudinal, colonic stretch increases synaptic input to mouse prevertebral ganglion neurons by Miller, Steven M, Szurszewski, J H

“…The relationship between longitudinal and circular muscle tension in the mouse colon and mechanosensory excitatory synaptic input to neurons in the superior…”
Get more information

Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract by Szurszewski, J. H., Farrugia, G.

“…In all mammalian species examined to date, there is a 10 mV or more gradient in resting membrane potential across the wall of the gastric antrum, small…”
Get full text