Search Results - "Szumlanski, C"

Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide by Lowry, P W, Franklin, C L, Weaver, A L, Szumlanski, C L, Mays, D C, Loftus, E V, Tremaine, W J, Lipsky, J J, Weinshilboum, R M, Sandborn, W J

“…AIM We evaluated the effect of coadministration of sulphasalazine, mesalamine, and balsalazide on the pharmacokinetics and pharmacodynamics of azathioprine and…”
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Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine by Szumlanski, CL, Weinshilboum, RM

“…Thiopurine drugs are used in the treatment of inflammatory bowel disease—as are sulphasalazine and its metabolite 5‐aminosalicylic acid (ASA). S‐Methylation…”
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Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis by Yan, Lan, Zhang, Shuichen, Eiff, Bianca, Szumlanski, Carol L., Powers, Melody, O'Brien, John F., Weinshilboum, Richard M.

“…Background Thiopurine methyltransferase (TPMT) is a genetically polymorphic enzyme that catalyzes the S‐methylation of thiopurine drugs such as…”
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Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization by AKSOY, S, SZUMLANSKI, C. L, WEINSHILBOUM, R. M

“…Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and other pyridines. Human liver NNMT activity has a bimodal frequency…”
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Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction by Lewis, Lionel D., Benin, Andrea, Szumlanski, Carol L., Otterness, Diane M., Lennard, Lynne, Weinshilboum, Richard M., Nierenberg, David W.

“…A patient with refractory Crohn's disease had two separate episodes of bone marrow suppression while receiving 50 to 75 mg 6‐mercaptopurine a day and 1000 to…”
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Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase by Weinshilboum, R M, Otterness, D M, Szumlanski, C L

“…Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase…”
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Balsalazide and azathioprine or 6-mercaptopurine: Evidence for a potentially serious drug interaction by Lowry, Philip W., Szumlanski, Carol L., Weinshilboum, Richard M., Sandborn, William J.

“…GASTROENTEROLOGY 1999;116:1505-1506…”
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Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency by ANDERSEN, J. B, SZUMLANSKI, C, WEINSHILBOUM, R. M, SCHMIEGELOW, K

“…Two children with acute lymphoblastic leukaemia (ALL) were found to be thiopurine methyltransferase (TPMT)-deficient by both genotype and phenotype. They were…”
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Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity by Otterness, D M, Szumlanski, C L, Wood, T C, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine. Large variations in levels of TPMT activity in human…”
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Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1 by Lee, D, Szumlanski, C, Houtman, J, Honchel, R, Rojas, K, Overhauser, J, Wieben, E D, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) is a genetically polymorphic enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. This…”
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Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation by Her, C, Szumlanski, C, Aksoy, I A, Weinshilboum, R M

“…Sulfate conjugation is an important metabolic pathway for many drugs, xenobiotic compounds, and steroid hormones. Human tissues express five cytoplasmic…”
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Purine substrates for human thiopurine methyltransferase by Deininger, M, Szumlanski, C L, Otterness, D M, Van Loon, J, Ferber, W, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). A genetic…”
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Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity by Preuss, C V, Wood, T C, Szumlanski, C L, Raftogianis, R B, Otterness, D M, Girard, B, Scott, M C, Weinshilboum, R M

“…Histamine N-methyltransferase (HNMT) catalyzes a major pathway in histamine metabolism. Levels of HNMT activity in humans are regulated by inheritance. We set…”
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Human intestinal phenol sulfotransferase: assay conditions, activity levels and partial purification of the thermolabile form by Sundaram, R S, Szumlanski, C, Otterness, D, van Loon, J A, Weinshilboum, R M

“…Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. The small intestine is an important…”
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Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA by Honchel, R, Aksoy, I A, Szumlanski, C, Wood, T C, Otterness, D M, Wieben, E D, Weinshilboum, R M

“…Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Levels of TPMT activity in human tissue are…”
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Toxicity and metabolism in mice of 2,6-dithiopurine, a potential chemopreventive agent by Qing, W G, Powell, K L, Stoica, G, Szumlanski, C L, Weinshilboum, R M, Macleod, M C

“…2,6-Dithiopurine (DTP) has been proposed as a possible chemopreventive agent because of its facile reaction with the electrophilic ultimate carcinogen,…”
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Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders by Lachman, H M, Papolos, D F, Saito, T, Yu, Y M, Szumlanski, C L, Weinshilboum, R M

“…Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism in humans is associated with a…”
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Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency by MCBRIDE, Kim L, GILCHRIST, Gerald S, SMITHSON, W. Anthony, WEINSHILBOUM, Richard M, SZUMLANSKI, Carol L

“…6-thioguanine (6TG) is undergoing investigation for use in the maintenance phase of acute lymphoblastic leukemia (ALL). Just as with 6-mercaptopurine (6MP), it…”
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Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage by Powis, G, Jardine, I, Van Dyke, R, Weinshilboum, R, Moore, D, Wilke, T, Rhodes, W, Nelson, R, Benson, L, Szumlanski, C

“…An investigation has been conducted on the foreign compound-metabolizing activity of human liver collected fresh from surgery or at autopsy from cadavers 3 to…”
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Histamine N-methyltransferase functional polymorphism: Lack of association with schizophrenia by Yan, Lan, Szumlanski, Carol L., Rice, Sharmon R., Sobell, Janet L., Lachman, Herbert M., Weinshilboum, Richard M.

“…Histamine is a central nervous system (CNS) neurotransmitter that has been implicated in the pathophysiology of schizophrenia. Histamine N‐methyltransferase…”
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