Search Results - "Szulc, M"

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line[S] by Podbielska, Maria, Szulc, Zdzisław M., Kurowska, Ewa, Hogan, Edward L., Bielawski, Jacek, Bielawska, Alicja, Bhat, Narayan R.

“…Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the…”
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C16-ceramide is a natural regulatory ligand of p53 in cellular stress response by Fekry, Baharan, Jeffries, Kristen A., Esmaeilniakooshkghazi, Amin, Szulc, Zdzislaw M., Knagge, Kevin J., Kirchner, David R., Horita, David A., Krupenko, Sergey A., Krupenko, Natalia I.

“…Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53…”
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Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry by Bielawski, Jacek, Szulc, Zdzislaw M., Hannun, Yusuf A., Bielawska, Alicja

“…There has been a recent explosion in research concerning novel bioactive sphingolipids (SPLs) such as ceramide (Cer), sphingosine (Sph) and sphingosine…”
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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase by Bai, Aiping, Mao, Cungui, Jenkins, Russell W, Szulc, Zdzislaw M, Bielawska, Alicja, Hannun, Yusuf A

“…Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic…”
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Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression by Kim, Sungjin, Alsaidan, Omar Awad, Goodwin, Octavia, Li, Qianjin, Sulejmani, Essilvo, Han, Zhen, Bai, Aiping, Albers, Thomas, Beharry, Zanna, Zheng, Y George, Norris, James S, Szulc, Zdzislaw M, Bielawska, Alicja, Lebedyeva, Iryna, Pegan, Scott D, Cai, Houjian

“…Protein -myristoylation enables localization to membranes and helps maintain protein conformation and function. -myristoyltransferases (NMT) catalyze co- or…”
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The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction by De Palma, Ryan M., Parnham, Stuart R., Li, Yitong, Oaks, Joshua J., Peterson, Yuri K., Szulc, Zdzislaw M., Roth, Braden M., Xing, Yongna, Ogretmen, Besim

“…ABSTRACT The su(var)3‐9, enhancer of zeste, trithorax (SET)/inhibitor 2 of protein phosphatase 2A (PP2A) oncoprotein binds and inhibits PP2A, composed of…”
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Distinctive sphingolipid patterns in chronic multiple sclerosis lesions by Podbielska, Maria, Szulc, Zdzislaw M., Ariga, Toshio, Pokryszko-Dragan, Anna, Fortuna, Wojciech, Bilinska, Małgorzata, Podemski, Ryszard, Jaskiewicz, Ewa, Kurowska, Ewa, Yu, Robert K., Hogan, Edward L.

“…Multiple sclerosis (MS) is a CNS disease characterized by immune-mediated demyelination and progressive axonal loss. MS-related CNS damage and its clinical…”
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis by Saddoughi, Sahar A., Gencer, Salih, Peterson, Yuri K., Ward, Katherine E., Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M., Thomas, Raquela J., Selvam, Shanmugam P., Senkal, Can E., Garrett‐Mayer, Elizabeth, De Palma, Ryan M., Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A., Stahelin, Robert V., Perrotti, Danilo, Ogretmen, Besim

“…Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour…”
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HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy by Thomas, Raquela J, Oleinik, Natalia, Panneer Selvam, Shanmugam, Vaena, Silvia G, Dany, Mohammed, Nganga, Rose N, Depalma, Ryan, Baron, Kyla D, Kim, Jisun, Szulc, Zdzislaw M, Ogretmen, Besim

“…Human papillomavirus (HPV) infection is linked to improved survival in response to chemo‐radiotherapy for patients with oropharynx head and neck squamous cell…”
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Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry by Bielawski, Jacek, Pierce, Jason S, Snider, Justin, Rembiesa, Barbara, Szulc, Zdzislaw M, Bielawska, Alicja

“…There has been a recent explosion in research concerning novel bioactive sphingolipids (SPLs) such as ceramide (Cer), sphingosine (Sph), and sphingosine…”
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Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-chain Ceramides, and Its Down-regulation Inhibits Both Cell Proliferation and Apoptosis by Hu, Wei, Xu, Ruijuan, Sun, Wei, Szulc, Zdzislaw M., Bielawski, Jacek, Obeid, Lina M., Mao, Cungui

“…Ceramides with different fatty acyl chains may vary in their physiological or pathological roles; however, it remains unclear how cellular levels of individual…”
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Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells by Kraveka, Jacqueline M., Li, Li, Szulc, Zdzislaw M., Bielawski, Jacek, Ogretmen, Besim, Hannun, Yusuf A., Obeid, Lina M., Bielawska, Alicja

“…The role of dihydroceramide desaturase as a key enzyme in the de novo pathway of ceramide generation was investigated in human neuroblastoma cells (SMS-KCNR)…”
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Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy by Sentelle, R David, Senkal, Can E, Jiang, Wenhui, Ponnusamy, Suriyan, Gencer, Salih, Panneer Selvam, Shanmugam, Ramshesh, Venkat K, Peterson, Yuri K, Lemasters, John J, Szulc, Zdzislaw M, Bielawski, Jacek, Ogretmen, Besim

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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors by Sheridan, Megan, Chowdhury, Nityananda, Wellslager, Bridgette, Oleinik, Natalia, Kassir, Mohamed Faisal, Lee, Han G., Engevik, Mindy, Peterson, Yuri, Pandruvada, Subramanya, Szulc, Zdzislaw M., Yilmaz, Özlem, Ogretmen, Besim

“…Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we…”
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LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria by Beckham, Thomas H, Lu, Ping, Jones, Elizabeth E, Marrison, Tucker, Lewis, Clayton S, Cheng, Joseph C, Ramshesh, Venkat K, Beeson, Gyda, Beeson, Craig C, Drake, Richard R, Bielawska, Alicja, Bielawski, Jacek, Szulc, Zdzislaw M, Ogretmen, Besim, Norris, James S, Liu, Xiang

“…Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally beneficial cytotoxic chemotherapy with gemcitabine. As the…”
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Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs by Bai, Aiping, Szulc, Zdzislaw M., Bielawski, Jacek, Pierce, Jason S., Rembiesa, Barbara, Terzieva, Silva, Mao, Cungui, Xu, Ruijuan, Wu, Bill, Clarke, Christopher J., Newcomb, Benjamin, Liu, Xiang, Norris, James, Hannun, Yusuf A., Bielawska, Alicja

“…[Display omitted] Acid ceramidase (ACDase) is being recognized as a therapeutic target for cancer. B13 represents a moderate inhibitor of ACDase. The present…”
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Bax and Bcl-xL exert their regulation on different sites of the ceramide channel by Perera, Meenu N, Lin, Shang H, Peterson, Yuri K, Bielawska, Alicja, Szulc, Zdzislaw M, Bittman, Robert, Colombini, Marco

“…The present study demonstrates the important structural features of ceramide required for proper regulation, binding and identification by both pro-apoptotic…”
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Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis by Hou, Qi, Jin, Junfei, Zhou, Hui, Novgorodov, Sergei A., Bielawska, Alicja, Szulc, Zdzislaw M., Hannun, Yusuf A., Obeid, Lina M., Hsu, Yi-Te

“…C6-pyridinium (d-erythro-2-N-[6′-(1′′-pyridinium)-hexanoyl]sphingosine bromide [LCL29]) is a cationic mitochondrion-targeting ceramide analog that promotes…”
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Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells by Mao, Zhehao, Sun, Wei, Xu, Ruijuan, Novgorodov, Sergei, Szulc, Zdzislaw M., Bielawski, Jacek, Obeid, Lina M., Mao, Cungui

“…Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has been implicated in the cytotoxicity of the synthetic retinoid…”
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Substrate Specificity, Membrane Topology, and Activity Regulation of Human Alkaline Ceramidase 2 (ACER2) by Sun, Wei, Jin, Junfei, Xu, Ruijuan, Hu, Wei, Szulc, Zdzislaw M., Bielawski, Jacek, Obeid, Lina M., Mao, Cungui

“…Human alkaline ceramidase 2 (ACER2) plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells. Here we report its…”
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