Search Results - "Sztretye, Monika"
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Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
Published in Oxidative medicine and cellular longevity (2019)“…Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox…”
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Unravelling the Effects of Syndecan-4 Knockdown on Skeletal Muscle Functions
Published in International journal of molecular sciences (01-04-2023)“…The remodelling of the extracellular matrix plays an important role in skeletal muscle development and regeneration. Syndecan-4 is a cell surface proteoglycan…”
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Genetic Manipulation of CB1 Cannabinoid Receptors Reveals a Role in Maintaining Proper Skeletal Muscle Morphology and Function in Mice
Published in International journal of molecular sciences (09-12-2022)“…The endocannabinoid system (ECS) refers to a widespread signaling system and its alteration is implicated in a growing number of human diseases. Cannabinoid…”
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From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies
Published in International journal of molecular sciences (25-11-2020)“…Muscular dystrophies are a group of more than 160 different human neuromuscular disorders characterized by a progressive deterioration of muscle mass and…”
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Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue
Published in International journal of molecular sciences (14-01-2022)“…Astaxanthin is a lipid-soluble carotenoid influencing lipid metabolism, body weight, and insulin sensitivity. We provide a systematic analysis of acute and…”
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Restricting calcium currents is required for correct fiber type specification in skeletal muscle
Published in Development (Cambridge) (01-05-2016)“…Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact, alternative splicing of the voltage-gated calcium channel…”
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SOCE Is Important for Maintaining Sarcoplasmic Calcium Content and Release in Skeletal Muscle Fibers
Published in Biophysical journal (05-12-2017)“…Store-operated Ca2+ entry (SOCE) is a Ca2+-entry process activated by the depletion of intracellular stores and has an important role in many cell types. In…”
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The Role of Orai1 in Regulating Sarcoplasmic Calcium Release, Mitochondrial Morphology and Function in Myostatin Deficient Skeletal Muscle
Published in Frontiers in physiology (21-12-2020)“…In mice a naturally occurring 12-bp deletion in the myostatin gene is considered responsible for the compact phenotype (Mstn , Cmpt) labeled by a tremendous…”
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Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca2+ release in skeletal muscle
Published in The Journal of general physiology (01-08-2011)“…The mechanisms that terminate Ca2+ release from the sarcoplasmic reticulum are not fully understood. D4cpv-Casq1 (Sztretye et al. 2011. J. Gen. Physiol…”
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Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling
Published in The Journal of physiology (15-03-2014)“…Key points Hypermuscularity associated with naturally occurring mutations in the myostatin gene as found in Compact mice results in increased muscle mass but…”
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D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle
Published in The Journal of general physiology (01-08-2011)“…Current fluorescent monitors of free [Ca(2+)] in the sarcoplasmic reticulum (SR) of skeletal muscle cells are of limited quantitative value. They provide…”
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Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle
Published in The Journal of general physiology (01-09-2010)“…Contractile activation in striated muscles requires a Ca(2+) reservoir of large capacity inside the sarcoplasmic reticulum (SR), presumably the protein…”
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Charged Surface Area of Maurocalcine Determines Its Interaction with the Skeletal Ryanodine Receptor
Published in Biophysical journal (01-10-2008)“…The 33 amino acid scorpion toxin maurocalcine (MCa) has been shown to modify the gating of the skeletal-type ryanodine receptor (RyR1). Here we explored the…”
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Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
Published in The Journal of physiology (01-12-2008)“…The 95 kDa triadin (Trisk 95), an integral protein of the sarcoplasmic reticular membrane in skeletal muscle, interacts with both the ryanodine receptor (RyR)…”
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Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin
Published in Cell death & disease (23-08-2023)“…Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients…”
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Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN
Published in Cell calcium (Edinburgh) (01-11-2009)“…Abstract TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)-ethylenediamine) is a membrane-permeable heavy-metal ion chelator with a dissociation constant for Ca2+…”
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Effect of TPEN on the calcium release of cultured C2C12 mouse myotubes
Published in Journal of muscle research and cell motility (01-10-2007)“…N,N,N',N'-tetrakis(2-pyridylmethyl)-ethilenediamine (TPEN) is a membrane permeable heavy metal chelator that has been used to study intracellular calcium…”
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Alterations in the calcium homeostasis of skeletal muscle from postmyocardial infarcted rats
Published in Pflügers Archiv (01-12-2007)“…In chronic heart failure, skeletal muscles develop a weakness that is not associated to an impaired circulatory function but rather to alterations in the…”
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Calcium Homeostasis Is Modified in Skeletal Muscle Fibers of Small Ankyrin1 Knockout Mice
Published in International journal of molecular sciences (09-07-2019)“…Small Ankyrins (sAnk1) are muscle-specific isoforms generated by the gene that participate in the organization of the sarcoplasmic reticulum (SR) of striated…”
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Assessing the Potential of Nutraceuticals as Geroprotectors on Muscle Performance and Cognition in Aging Mice
Published in Antioxidants (04-09-2021)“…Aging and frailty are associated with a decline in muscle force generation, which is a direct consequence of reduced muscle quantity and quality. Among the…”
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