Search Results - "Szpyt, John"

Quantitative Proteomics of the Cancer Cell Line Encyclopedia by Nusinow, David P., Szpyt, John, Ghandi, Mahmoud, Rose, Christopher M., McDonald, E. Robert, Kalocsay, Marian, Jané-Valbuena, Judit, Gelfand, Ellen, Schweppe, Devin K., Jedrychowski, Mark, Golji, Javad, Porter, Dale A., Rejtar, Tomas, Wang, Y. Karen, Kryukov, Gregory V., Stegmeier, Frank, Erickson, Brian K., Garraway, Levi A., Sellers, William R., Gygi, Steven P.

“…Proteins are essential agents of biological processes. To date, large-scale profiling of cell line collections including the Cancer Cell Line Encyclopedia…”
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Dual proteome-scale networks reveal cell-specific remodeling of the human interactome by Huttlin, Edward L., Bruckner, Raphael J., Navarrete-Perea, Jose, Cannon, Joe R., Baltier, Kurt, Gebreab, Fana, Gygi, Melanie P., Thornock, Alexandra, Zarraga, Gabriela, Tam, Stanley, Szpyt, John, Gassaway, Brandon M., Panov, Alexandra, Parzen, Hannah, Fu, Sipei, Golbazi, Arvene, Maenpaa, Eila, Stricker, Keegan, Guha Thakurta, Sanjukta, Zhang, Tian, Rad, Ramin, Pan, Joshua, Nusinow, David P., Paulo, Joao A., Schweppe, Devin K., Vaites, Laura Pontano, Harper, J. Wade, Gygi, Steven P.

“…Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through…”
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Architecture of the human interactome defines protein communities and disease networks by Huttlin, Edward L., Bruckner, Raphael J., Paulo, Joao A., Cannon, Joe R., Ting, Lily, Baltier, Kurt, Colby, Greg, Gebreab, Fana, Gygi, Melanie P., Parzen, Hannah, Szpyt, John, Tam, Stanley, Zarraga, Gabriela, Pontano-Vaites, Laura, Swarup, Sharan, White, Anne E., Schweppe, Devin K., Rad, Ramin, Erickson, Brian K., Obar, Robert A., Guruharsha, K. G., Li, Kejie, Artavanis-Tsakonas, Spyros, Gygi, Steven P., Harper, J. Wade

“…Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived…”
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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 by Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.

“…Uncoupling protein 1 (UCP1)-dependent thermogenesis in brown adipose tissue is supported by a burst of mitochondrial reactive oxygen species upon cold…”
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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry by Jedrychowski, Mark P., Wrann, Christiane D., Paulo, Joao A., Gerber, Kaitlyn K., Szpyt, John, Robinson, Matthew M., Nair, K. Sreekumaran, Gygi, Steven P., Spiegelman, Bruce M.

“…Exercise provides many health benefits, including improved metabolism, cardiovascular health, and cognition. We have shown previously that FNDC5, a type I…”
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The BioPlex Network: A Systematic Exploration of the Human Interactome by Huttlin, Edward L., Ting, Lily, Bruckner, Raphael J., Gebreab, Fana, Gygi, Melanie P., Szpyt, John, Tam, Stanley, Zarraga, Gabriela, Colby, Greg, Baltier, Kurt, Dong, Rui, Guarani, Virginia, Vaites, Laura Pontano, Ordureau, Alban, Rad, Ramin, Erickson, Brian K., Wühr, Martin, Chick, Joel, Zhai, Bo, Kolippakkam, Deepak, Mintseris, Julian, Obar, Robert A., Harris, Tim, Artavanis-Tsakonas, Spyros, Sowa, Mathew E., De Camilli, Pietro, Paulo, Joao A., Harper, J. Wade, Gygi, Steven P.

“…Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput…”
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UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction by Kazak, Lawrence, Chouchani, Edward T., Stavrovskaya, Irina G., Lu, Gina Z., Jedrychowski, Mark P., Egan, Daniel F., Kumari, Manju, Kong, Xingxing, Erickson, Brian K., Szpyt, John, Rosen, Evan D., Murphy, Michael P., Kristal, Bruce S., Gygi, Steven P., Spiegelman, Bruce M.

“…Brown adipose tissue (BAT) mitochondria exhibit high oxidative capacity and abundant expression of both electron transport chain components and uncoupling…”
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Global and tissue-specific aging effects on murine proteomes by Keele, Gregory R., Zhang, Ji-Gang, Szpyt, John, Korstanje, Ron, Gygi, Steven P., Churchill, Gary A., Schweppe, Devin K.

“…Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed…”
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Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity by Jedrychowski, Mark P., Lu, Gina Z., Szpyt, John, Mariotti, Marco, Garrity, Ryan, Paulo, Joao A., Schweppe, Devin K., Laznik-Bogoslavski, Dina, Kazak, Lawrence, Murphy, Michael P., Gladyshev, Vadim N., Gygi, Steven P., Chouchani, Edward T., Spiegelman, Bruce M.

“…Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular…”
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Global proteomics of Ubqln2-based murine models of ALS by Whiteley, Alexandra M., Prado, Miguel A., de Poot, Stefanie A.H., Paulo, Joao A., Ashton, Marissa, Dominguez, Sara, Weber, Martin, Ngu, Hai, Szpyt, John, Jedrychowski, Mark P., Easton, Amy, Gygi, Steven P., Kurz, Thimo, Monteiro, Mervyn J., Brown, Eric J., Finley, Daniel

“…Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery…”
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Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes by Hong, Shangyu, Song, Wei, Zushin, Peter-James H., Liu, Bingyang, Jedrychowski, Mark P., Mina, Amir I., Deng, Zhaoming, Cabarkapa, Dimitrije, Hall, Jessica A., Palmer, Colin J., Aliakbarian, Hassan, Szpyt, John, Gygi, Steven P., Tavakkoli, Ali, Lynch, Lydia, Perrimon, Norbert, Banks, Alexander S.

“…The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling…”
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UCP1 governs liver extracellular succinate and inflammatory pathogenesis by Mills, Evanna L., Harmon, Cathal, Jedrychowski, Mark P., Xiao, Haopeng, Garrity, Ryan, Tran, Nhien V., Bradshaw, Gary A., Fu, Accalia, Szpyt, John, Reddy, Anita, Prendeville, Hannah, Danial, Nika N., Gygi, Steven P., Lynch, Lydia, Chouchani, Edward T.

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A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging by Xiao, Haopeng, Jedrychowski, Mark P., Schweppe, Devin K., Huttlin, Edward L., Yu, Qing, Heppner, David E., Li, Jiaming, Long, Jiani, Mills, Evanna L., Szpyt, John, He, Zhixiang, Du, Guangyan, Garrity, Ryan, Reddy, Anita, Vaites, Laura Pontano, Paulo, Joao A., Zhang, Tinghu, Gray, Nathanael S., Gygi, Steven P., Chouchani, Edward T.

“…Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species…”
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 by Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

“…WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory…”
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation by Mills, Evanna L., Harmon, Cathal, Jedrychowski, Mark P., Xiao, Haopeng, Gruszczyk, Anja V., Bradshaw, Gary A., Tran, Nhien, Garrity, Ryan, Laznik-Bogoslavski, Dina, Szpyt, John, Prendeville, Hannah, Lynch, Lydia, Murphy, Michael P., Gygi, Steven P., Spiegelman, Bruce M., Chouchani, Edward T.

“…Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte energy expenditure and metabolic homeostasis. However, the widely employed UCP1…”
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UCP1 governs liver extracellular succinate and inflammatory pathogenesis by Mills, Evanna L., Harmon, Cathal, Jedrychowski, Mark P., Xiao, Haopeng, Garrity, Ryan, Tran, Nhien V., Bradshaw, Gary A., Fu, Accalia, Szpyt, John, Reddy, Anita, Prendeville, Hannah, Danial, Nika N., Gygi, Steven P., Lynch, Lydia, Chouchani, Edward T.

“…Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is intimately linked with obesity and type 2 diabetes. Liver…”
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Correction: Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 by Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.

“…Nature 532, 112–116 (2016); doi:10.1038/nature17399 In this Letter, owing to a typographical error, Fig. 4h was erroneously referred to as Fig. 4j in the text…”
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Erratum: Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 by Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.

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Three-Dimensional Localization of the α and β Subunits and of the II-III Loop in the Skeletal Muscle L-type Ca2+ Channel by Szpyt, John, Lorenzon, Nancy, Perez, Claudio F., Norris, Ethan, Allen, Paul D., Beam, Kurt G., Samsó, Montserrat

“…The L-type Ca2+ channel (dihydropyridine receptor (DHPR) in skeletal muscle acts as the voltage sensor for excitation-contraction coupling. To better resolve…”
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Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 by Chouchani, Edward T, Kazak, Lawrence, Jedrychowski, Mark P, Lu, Gina Z, Erickson, Brian K, Szpyt, John, Pierce, Kerry A, Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B, Robinson, Alan J, Gygi, Steve P, Spiegelman, Bruce M

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