Search Results - "Szpila, Benjamin"

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock by Mathias, Brittany, Delmas, Amber L, Ozrazgat-Baslanti, Tezcan, Vanzant, Erin L, Szpila, Benjamin E, Mohr, Alicia M, Moore, Frederick A, Brakenridge, Scott C, Brumback, Babette A, Moldawer, Lyle L, Efron, Philip A

“…OBJECTIVE:We hypothesized that after sepsis in humans, MDSCs will be persistently increased, functionally immunosuppressive, and associated with adverse…”
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A Review of GM-CSF Therapy in Sepsis by Mathias, Brittany, Szpila, Benjamin E., Moore, Frederick A., Efron, Philip A., Moldawer, Lyle L.

“…Determine what clinical role, if any, GM-CSF may have in the clinical treatment of sepsis in the adult patient. Advancements in the management of sepsis have…”
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Host responses to sepsis vary in different low-lethality murine models by Gentile, Lori F, Nacionales, Dina C, Lopez, M Cecilia, Vanzant, Erin, Cuenca, Angela, Szpila, Benjamin E, Cuenca, Alex G, Joseph, Anna, Moore, Frederick A, Leeuwenburgh, Christiaan, Baker, Henry V, Moldawer, Lyle L, Efron, Philip A

“…Animal models for the study of sepsis are being increasingly scrutinized, despite their essential role for early translational research. In particular, recent…”
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Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock by Vanzant, Erin L, Hilton, Rachael E, Lopez, Cecilia M, Zhang, Jianyi, Ungaro, Ricardo F, Gentile, Lori F, Szpila, Benjamin E, Maier, Ronald V, Cuschieri, Joseph, Bihorac, Azra, Leeuwenburgh, Christiaan, Moore, Frederick A, Baker, Henry V, Moldawer, Lyle L, Brakenridge, Scott C, Efron, Philip A

“…We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with…”
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Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit by Szpila, Benjamin E, Ozrazgat-Baslanti, Tezcan, Zhang, Jianyi, Lanz, Jennifer, Davis, Ruth, Rebel, Annette, Vanzant, Erin, Gentile, Lori F, Cuenca, Alex G, Ang, Darwin N, Liu, Huazhi, Lottenberg, Lawrence, Marker, Peggy, Zumberg, Marc, Bihorac, Azra, Moore, Frederick A, Brakenridge, Scott, Efron, Philip A

“…Blood product transfusions are associated with increased morbidity and mortality. The purpose of this study was to determine if implementation of a restrictive…”
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Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis by Mira, Juan C, Szpila, Benjamin E, Nacionales, Dina C, Lopez, Maria-Cecilia, Gentile, Lori F, Mathias, Brittany J, Vanzant, Erin L, Ungaro, Ricardo, Holden, David, Rosenthal, Martin D, Rincon, Jaimar, Verdugo, Patrick T, Larson, Shawn D, Moore, Frederick A, Brakenridge, Scott C, Mohr, Alicia M, Baker, Henry V, Moldawer, Lyle L, Efron, Philip A

“…Controversy remains whether the leukocyte genomic response to trauma or sepsis is dependent upon the initiating stimulus. Previous work illustrated poor…”
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Single-Center Cost Analysis Comparing High-Risk Carotid Endarterectomy and Transcarotid Artery Revascularization by Jayarajan, Senthil, Szpila, Benjamin, Jim, Jeffrey

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A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged by Nacionales, Dina C, Szpila, Benjamin, Ungaro, Ricardo, Lopez, M Cecilia, Zhang, Jianyi, Gentile, Lori F, Cuenca, Angela L, Vanzant, Erin, Mathias, Brittany, Jyot, Jeevan, Westerveld, Donevan, Bihorac, Azra, Joseph, Anna, Mohr, Alicia, Duckworth, Lizette V, Moore, Frederick A, Baker, Henry V, Leeuwenburgh, Christiaan, Moldawer, Lyle L, Brakenridge, Scott, Efron, Philip A

“…The elderly are particularly susceptible to trauma, and their outcomes are frequently dismal. Such patients often have complicated clinical courses and…”
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Host Responses to Sepsis Vary in Different Low-Lethality Murine Models: e94404 by Gentile, Lori F, Nacionales, Dina C, Lopez, M Cecilia, Vanzant, Erin, Cuenca, Angela, Szpila, Benjamin E, Cuenca, Alex G, Joseph, Anna, Moore, Frederick A, Leeuwenburgh, Christiaan

“…Introduction Animal models for the study of sepsis are being increasingly scrutinized, despite their essential role for early translational research. In…”
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