Search Results - "Szpera, Robert"

The Fluorination of C−H Bonds: Developments and Perspectives by Szpera, Robert, Moseley, Daniel F. J., Smith, Lewis B., Sterling, Alistair J., Gouverneur, Véronique

“…This Review summarizes advances in fluorination by C(sp2)−H and C(sp3)−H activation. Transition‐metal‐catalyzed approaches championed by palladium have allowed…”
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The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers by Szpera, Robert, Kovalenko, Nadia, Natarajan, Kalaiselvi, Paillard, Nina, Linclau, Bruno

“…The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts…”
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Fluorierung von C‐H‐Bindungen: Entwicklungen und Perspektiven by Szpera, Robert, Moseley, Daniel F. J., Smith, Lewis B., Sterling, Alistair J., Gouverneur, Véronique

“…Abstract Dieser Aufsatz gibt einen aktuellen Überblick über Fluorierungen per C(sp 2 )‐H‐ und C(sp 3 )‐H‐Aktivierung. Übergangsmetallkatalysierte Methoden…”
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18F-Difluoromethyl(ene) Motifs via Oxidative Fluorodecarboxylation with 18FFluoride by Ortalli, Sebastiano, d, Joseph, Szpera, Robert, Stoessel, Barbara, Trabanco, Andrés A, Tredwell, Matthew, Gouverneur, Véronique

“…Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative 18F-fluorodecarboxylation with [18F]fluoride affording biologically…”
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Commercial Route Development Toward PF-07265807, an AXL-MER Inhibitor Oncology Candidate by Critcher, Douglas J., Ashcroft, Christopher Paul, Pettman, Alan J., Badland, Matthew, Szpera, Robert, Waddington, William

“…Our route scouting efforts toward finding the most efficient construction of PF-07265807 (ARRY-067) in readiness for process development prior to commercial…”
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18 F-Difluoromethyl(ene) Motifs via Oxidative Fluorodecarboxylation with [ 18 F]Fluoride by Ortalli, Sebastiano, Ford, Joseph, Szpera, Robert, Stoessel, Barbara, Trabanco, Andrés A, Tredwell, Matthew, Gouverneur, Véronique

“…Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative F-fluorodecarboxylation with [ F]fluoride affording biologically relevant…”
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18F‑Difluoromethyl(ene) Motifs via Oxidative Fluorodecarboxylation with [18F]Fluoride by Ortalli, Sebastiano, Ford, Joseph, Szpera, Robert, Stoessel, Barbara, Trabanco, Andrés A., Tredwell, Matthew, Gouverneur, Véronique

“…Herein, we report that α-fluorocarboxylic acids undergo manganese-mediated oxidative 18F-fluorodecarboxylation with [18F]­fluoride affording biologically…”
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Recent Advances in Nonprecious Metal Catalysis by Bernhardson, David, Hansen, Eric C., Hubbell, Aran K., Singer, Robert A., Szpera, Robert, Tcyrulnikov, Sergei, Vicini, Anna Chiara, Monfette, Sebastien

“…As the field of nonprecious metal catalysis continues to expand, we pursue a review series covering selected transformations in this area over a short time…”
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New Methods for F-18 Radiolabelling by Szpera, Robert

“…Chapter 1 - Introduction: briefly introduces the fundamental principles of positron emission tomography (PET). The different isotopes commonly employed in PET…”
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Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling by Szpera, Robert, Isenegger, Patrick G, Ghosez, Maxime, Straathof, Natan J. W, Cookson, Rosa, Blakemore, David C, Richardson, Paul, Gouverneur, Véronique

“…Herein, we report a highly effective protocol for the cross-coupling of (hetero)­aryl bromides with fluorinated alcohols using the commercially available…”
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Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides by Hyde, Stephen, Veliks, Janis, Ascough, David M.H., Szpera, Robert, Paton, Robert S., Gouverneur, Véronique

“…Aryl substituted 2,2,2-trifluorodiazoethanes undergo rhodium(II)-catalysed insertion reactions with tin hydrides affording the corresponding…”
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Conformational influence of fluorinated building blocks on the physical properties of polyesters by Lingier, Sophie, Szpera, Robert, Goderis, Bart, Linclau, Bruno, Du Prez, Filip E.

“…The interplay of the relative configuration of diastereomeric vicinal difluoride groups on the conformational properties of polyesters has been investigated…”
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Molecular machines for catalysis by van Dijk, Lucy, Tilby, Michael J., Szpera, Robert, Smith, Owen A., Bunce, Holly A. P., Fletcher, Stephen P.

“…The past few decades have seen tremendous progress in the synthesis and operation of molecular systems capable of controlled mechanical movement. Here, we…”
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Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir by Szpera, Robert, Huang, Shanjun, Fenton, Harriet A. M., Waddington, William, Gymer, Adam E. S., Moses, Ian B., Buck, Julia, Ingram, Heather, Fussell, Steven J., Walton, Robert, Shanahan, Charles S., Aleshire, Sarah L., Robey, Juliana M. S., Kalmode, Hanuman P., Nuckols, Michel C., Kalikinidi, Nageswara R., Janganati, Venumadhav, Joyasawal, Sipak, Amarasekarage, Chanaka M., Senanayake, Chris H., Gupton, B. Frank

“…Nirmatrelvir is an inhibitor of the SARS-CoV-2 main protease and is the active ingredient in Paxlovid. Nirmatrelvir presents a significant synthetic challenge,…”
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Synthesis and Structural Characteristics of all Mono- and Difluorinated 4,6-Dideoxy‑d-xylo-hexopyranoses by Wheatley, David E, Fontenelle, Clement Q, Kuppala, Ramakrishna, Szpera, Robert, Briggs, Edward L, Vendeville, Jean-Baptiste, Wells, Neil J, Light, Mark E, Linclau, Bruno

“…Protein–carbohydrate interactions are implicated in many biochemical/biological processes that are fundamental to life and to human health. Fluorinated…”
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Fluorierung von C‐H‐Bindungen: Entwicklungen und Perspektiven by Szpera, Robert, Moseley, Daniel F. J., Smith, Lewis B., Sterling, Alistair J., Gouverneur, Véronique

“…Dieser Aufsatz gibt einen aktuellen Überblick über Fluorierungen per C(sp2)‐H‐ und C(sp3)‐H‐Aktivierung. Übergangsmetallkatalysierte Methoden haben den regio‐…”
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Fluorierung von C‐H‐Bindungen: Entwicklungen und Perspektiven by Szpera, Robert, Moseley, Daniel F J, Smith, Lewis B, Sterling, Alistair J, Gouverneur, Véronique

“…Dieser Aufsatz gibt einen aktuellen Überblick über Fluorierungen per C(sp2)‐H‐ und C(sp3)‐H‐Aktivierung. Übergangsmetallkatalysierte Methoden haben den regio‐…”
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