Search Results - "Szpechcinski, Adam"

miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives by Florczuk, Mateusz, Szpechcinski, Adam, Chorostowska-Wynimko, Joanna

“…Lung cancer is the most common cancer worldwide. Up to 85% of lung cancer cases are diagnosed as non-small cell lung cancer (NSCLC). The effectiveness of NSCLC…”
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The Advantage of Targeted Next-Generation Sequencing over qPCR in Testing for Druggable EGFR Variants in Non-Small-Cell Lung Cancer by Szpechcinski, Adam, Moes-Sosnowska, Joanna, Skronska, Paulina, Lechowicz, Urszula, Pelc, Magdalena, Szolkowska, Malgorzata, Rudzinski, Piotr, Wojda, Emil, Maszkowska-Kopij, Krystyna, Langfort, Renata, Orlowski, Tadeusz, Sliwinski, Pawel, Polaczek, Mateusz, Chorostowska-Wynimko, Joanna

“…The emergence of targeted therapies in non-small-cell lung cancer (NSCLC), including inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase, has…”
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miR-625-3p and lncRNA GAS5 in Liquid Biopsies for Predicting the Outcome of Malignant Pleural Mesothelioma Patients Treated with Neo-Adjuvant Chemotherapy and Surgery by Kresoja-Rakic, Jelena, Szpechcinski, Adam, Kirschner, Michaela B, Ronner, Manuel, Minatel, Brenda, Martinez, Victor D, Lam, Wan L, Weder, Walter, Stahel, Rolf, Früh, Martin, Cerciello, Ferdinando, Felley-Bosco, Emanuela

“…Combining neo-adjuvant chemotherapy and surgery is part of multimodality treatment of malignant pleural mesothelioma (MPM), but not all patients benefit from…”
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Clinical significance of TP53 alterations in advanced NSCLC patients treated with EGFR, ALK and ROS1 tyrosine kinase inhibitors: An update by Moes-Sosnowska, Joanna, Szpechcinski, Adam, Chorostowska-Wynimko, Joanna

“… The development of targeted therapies for non-small cell lung cancer (NSCLC), such as the epidermal growth factor receptor (EGFR), anaplastic lymphoma…”
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Current perspectives on the use of miRNA as a biomarker for EGFR-targeted therapy for non-small cell lung cancer by Florczuk, Mateusz, Szpechciński, Adam, Chorostowska-Wynimko, Joanna

“…Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer in the world. Currently, a large number of research studies are conducted to…”
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Plasma cell-free DNA levels and integrity in patients with chest radiological findings: NSCLC versus benign lung nodules by Szpechcinski, Adam, Rudzinski, Piotr, Kupis, Wlodzimierz, Langfort, Renata, Orlowski, Tadeusz, Chorostowska-Wynimko, Joanna

“…Highlights • NSCLC patients present significantly higher plasma cfDNA levels than those with benign lung tumours. • Plasma cfDNA integrity is significantly…”
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Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT , ERBB2 , KRAS , and TP53 in 30% of Thymic Carcinomas by Szpechcinski, Adam, Szolkowska, Malgorzata, Winiarski, Sebastian, Lechowicz, Urszula, Wisniewski, Piotr, Knetki-Wroblewska, Magdalena

“…A better understanding of the molecular pathogenesis of thymic epithelial tumours (TETs) could revolutionise their treatment. We evaluated thymomas and thymic…”
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Coexistence of Borrelia burgdorferi s.l. genospecies within Ixodes ricinus ticks from central and eastern Poland by Sytykiewicz, Hubert, Karbowiak, Grzegorz, Chorostowska-Wynimko, Joanna, Szpechciński, Adam, Supergan-Marwicz, Marta, Horbowicz, Marcin, Szwed, Magdalena, Czerniewicz, Paweł, Sprawka, Iwona

“…The purpose of the study was to assess the prevalence and coinfection rates of Borrelia burgdorferi sensu lato genotypes in Ixodes ricinus (L.) ticks sampled…”
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The expression of circulating miR-504 in plasma is associated with EGFR mutation status in non-small-cell lung carcinoma patients by Szpechcinski, Adam, Florczuk, Mateusz, Duk, Katarzyna, Zdral, Aneta, Rudzinski, Stefan, Bryl, Maciej, Czyzewicz, Grzegorz, Rudzinski, Piotr, Kupis, Wlodzimierz, Wojda, Emil, Giedronowicz, Dorota, Langfort, Renata, Barinow-Wojewodzki, Aleksander, Orlowski, Tadeusz, Chorostowska‐Wynimko, Joanna

“…MicroRNAs (miRNAs), key regulators of gene expression at the post-transcriptional level, are grossly misregulated in some human cancers, including…”
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Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in IKIT/I, IERBB2/I, IKRAS/I, and ITP53/I in 30% of Thymic Carcinomas by Szpechcinski, Adam, Szolkowska, Malgorzata, Winiarski, Sebastian, Lechowicz, Urszula, Wisniewski, Piotr, Knetki-Wroblewska, Magdalena

“…The biology of thymic epithelial tumours (TETs), including thymomas and thymic carcinomas, and particularly the extent of molecular dysregulation, is poorly…”
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The impact of genetic markers on the diagnosis of lung cancer: a current perspective by Chorostowska-Wynimko, Joanna, Szpechcinski, Adam

“…Lung cancer is the leading worldwide source of cancer-related death. It is acknowledged that prognosis and treatment outcomes in lung cancer might be improved…”
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Molecular evidence of Anaplasma phagocytophilum and Babesia microti co-infections in Ixodes ricinus ticks in central-eastern region of Poland by Sytykiewicz, Hubert, Karbowiak, Grzegorz, Hapunik, Joanna, Szpechciński, Adam, Supergan-Marwicz, Marta, Goławska, Sylwia, Sprawka, Iwona, Czerniewicz, Paweł

“…The aim of the study was to elucidate the distribution of Anaplasma phagocytophilum and Babesia microti co-infection in Ixodes ricinus populations within the…”
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Studies of hepatocyte growth factor in bronchoalveolar lavage fluid in chronic interstitial lung diseases by Przybylski, Grzegorz, Chorostowska-Wynimko, Joanna, Dyczek, Andrzej, Wędrowska, Ewelina, Jankowski, Marek, Szpechciński, Adam, Giżycka, Agata, Golińska, Joanna, Kopiński, Piotr

“… Previous studies have suggested that hepatocyte growth factor (HGF) inhibits lung fibrosis as an antagonist of transforming growth factor β (TGF‑β).  We…”
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Detection of EGFR mutations in liquid biopsy samples using allele-specific quantitative PCR: A comparative real-world evaluation of two popular diagnostic systems by Szpechcinski, Adam, Bryl, Maciej, Wojcik, Piotr, Czyzewicz, Grzegorz, Wojda, Emil, Rudzinski, Piotr, Duk, Katarzyna, Moes-Sosnowska, Joanna, Maszkowska-Kopij, Krystyna, Langfort, Renata, Barinow-Wojewodzki, Aleksander, Chorostowska-Wynimko, Joanna

“…The detection of epidermal growth factor receptor (EGFR) mutations in plasma cell-free DNA (cfDNA) is an auxiliary tool for the molecular diagnosis of…”
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AB006. Molecular profiling of genetic alterations in thymic epithelial tumors by targeted next generation sequencing: a pilot study by Szpechcinski, Adam, Szolkowska, Malgorzata, Winiarski, Sebastian, Lechowicz, Urszula, Wisniewski, Piotr, Knetki-Wroblewska, Magdalena

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Quantitative analysis of free-circulating DNA in plasma of patients with resectable NSCLC by Szpechcinski, Adam, Chorostowska-Wynimko, Joanna, Kupis, Wlodzimierz, Maszkowska-Kopij, Krystyna, Dancewicz, Maciej, Kowalewski, Janusz, Orlowski, Tadeusz

“…Minute amounts of free-circulating DNA are present in plasma of healthy individuals, whereas its increased concentration was observed in patients with…”
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Reliable detection of rare mutations in EGFR gene codon L858 by PNA-LNA PCR clamp in non-small cell lung cancer by Skronski, Michal, Chorostowska-Wynimko, Joanna, Szczepulska, Ewa, Szpechcinski, Adam, Rudzinski, Piotr, Orlowski, Tadeusz, Langfort, Renata

“…PNA-LNA PCR clamp real-time PCR method represents allele-specific approach to mutation analysis of EGFR gene in NSCLC. Due to its unique design, it is…”
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Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs) by Kopiński, Piotr, Balicka-Ślusarczyk, Barbara, Dyczek, Andrzej, Szpechciński, Adam, Przybylski, Grzegorz, Jarzemska, Agnieszka, Wandtke, Tomasz, Jankowski, Marek, Iwaniec, Teresa, Chorostowska-Wynimko, Joanna

“…The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively…”
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P21. Immunohistochemistry versus DNA testing for detection of EGFR mutations and ALK rearrangements in lung adenocarcinoma patients by Skronski, Michal, Szpechcinski, Adam, Langfort, Renata, Jagus, Paulina, Gizycka, Agata, Giedronowicz, Dorota, Chorostowska-Wynimko, Joanna

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Simple flow cytometric protocol of CD4+/CD8+ lymphocyte ratio assessment in bronchoalveolar lavage fluids from patients with interstitial lung diseases by Szpechcinski, Adam, Kopinski, Piotr, Giedronowicz, Dorota, Rozy, Adriana, Jagus, Paulina, Szolkowska, Malgorzata, Chorostowska-Wynimko, Joanna

“…To validate the fast and accurate flow cytometric (FCM) protocol using blood-standardized antibodies for alveolar lymphocyte subtyping with respect to standard…”
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