Search Results - "Szollosi, Andras"

Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel by Szollosi, Andras

“…The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved…”
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Functional characterization of the transient receptor potential melastatin 2 (TRPM2) cation channel from Nematostella vectensis reconstituted into lipid bilayer by Szollosi, Andras, Almássy, János

“…Transient receptor potential melastatin 2 (TRPM2) cation channel activity is required for insulin secretion, immune cell activation and body heat control…”
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Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation by Zhang, Zhe, Tóth, Balázs, Szollosi, Andras, Chen, Jue, Csanády, László

“…Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat…”
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Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates by Iordanov, Iordan, Tóth, Balázs, Szollosi, Andras, Csanády, László

“…Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It…”
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Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein by Simon, Márton A, Iordanov, Iordan, Szollosi, Andras, Csanády, László

“…CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule…”
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The structure of the KtrAB potassium transporter by Vieira-Pires, Ricardo S., Szollosi, Andras, Morais-Cabral, João H.

“…In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought…”
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Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter by Szollosi, Andras, Vieira-Pires, Ricardo S, Teixeira-Duarte, Celso M, Rocha, Rita, Morais-Cabral, João H

“…KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation (K+ and Na+) transport proteins that closely resemble K+ channels. These proteins underlie a…”
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Conformational changes in the catalytically inactive nucleotide-binding site of CFTR by Csanády, László, Mihályi, Csaba, Szollosi, Andras, Töröcsik, Beáta, Vergani, Paola

“…A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic…”
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Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating by Szollosi, Andras, Muallem, Daniella R, Csanády, László, Vergani, Paola

“…Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel belonging to the adenosine triphosphate (ATP)-binding cassette (ABC)…”
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Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2 by Szollosi, Andras, Vergani, Paola, Csanády, László

“…The chloride ion channel cystic fibrosis transmembrane conductance regulator (CFTR) displays a typical adenosine trisphosphate (ATP)-binding cassette (ABC)…”
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Overnight Culture Unmasks Glucose-induced Insulin Secretion in Mouse Islets Lacking ATP-sensitive K+ Channels by Improving the Triggering Ca2+ Signal by Szollosi, Andras, Nenquin, Myriam, Henquin, Jean-Claude

“…A current model ascribes glucose-induced insulin secretion to the interaction of a triggering pathway (KATP channel-dependent Ca2+ influx and rise in cytosolic…”
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Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2β by Henquin, Jean-Claude, Nenquin, Myriam, Szollosi, Andras, Kubosaki, Atsutaka, Louis Notkins, Abner

“…Islet antigen-2 (IA-2 or ICA 512) and IA-2β (or phogrin) are major autoantigens in type 1 diabetes. They are located in dense core secretory vesicles including…”
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Structural determinants of protein kinase A essential for CFTR channel activation by Mihályi, Csaba, Iordanov, Iordan, Szollosi, Andras, Csanády, László

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the anion channel mutated in cystic fibrosis (CF) patients, is activated by the catalytic subunit…”
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A conserved mechanism couples cytosolic domain movements to pore gating in the TRPM2 channel by Tóth, Balázs, Jiang, Yuefeng, Szollosi, Andras, Zhang, Zhe, Csanády, László

“…Transient Receptor Potential Melastatin 2 (TRPM2) cation channels contribute to immunocyte activation, insulin secretion, and central thermoregulation. TRPM2…”
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Posttranslational modifications of cyclic AMP-dependent protein kinase a affect its binding to the CFTR anion channel by Szollosi, Andras, Mihalyi, Csaba, Iordanov, Iordan, Csanady, Laszlo

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The structures of protein kinase A in complex with CFTR: Mechanisms of phosphorylation and noncatalytic activation by Fiedorczuk, Karol, Iordanov, Iordan, Mihályi, Csaba, Szollosi, Andras, Csanády, László, Chen, Jue

“…Protein kinase A (PKA) is a key regulator of cellular functions by selectively phosphorylating numerous substrates, including ion channels, enzymes, and…”
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Dissecting the molecular mechanism of nucleotide-dependent activation of the KtrAB [K.sup.+] transporter by Szollosi, Andras, Vieira-Pires, Ricardo S, Teixeira-Duarte, Celso M, Rocha, Rita, Morais-Cabral, Joao H

“…KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation ([K.sup.+] and [Na.sup.+]) transport proteins that closely resemble [K.sup.+] channels. These…”
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Functional Characterization of the KtrAB Potassium Transport System by Szollosi, Andras, Vieira-Pires, Ricardo S., Morais-Cabral, João H.

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Conformational Changes in the Catalytically Inactive Nucleotide Binding Site of CFTR by Mihalyi, Csaba, Szollosi, Andras, Vergani, Paola, Csanady, Laszlo

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The Structure of the KtrAB Potassium Transporter by Vieira-Pires, Ricardo, Szollosi, Andras, Morais-Cabral, João

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