Search Results - "Sznaidman, Marcos L."

Studies on the Total Synthesis of Tallysomycin. Synthesis of the Threonylbithiazole Moiety Containing a Structurally Unique Glycosylcarbinolamide by Sznaidman, Marcos L, Hecht, Sidney M

“…Tallysomycins are glycopeptide antibiotics that were first isolated from fermentation broths of Streptoalloteichus hindustanus. They are structurally related…”
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A Selective Peroxisome Proliferator-Activated Receptor δ Agonist Promotes Reverse Cholesterol Transport by Oliver, William R., Shenk, Jennifer L., Snaith, Mike R., Russell, Caroline S., Plunket, Kelli D., Bodkin, Noni L., Lewis, Michael C., Winegar, Deborah A., Sznaidman, Marcos L., Lambert, Millard H., Xu, H. Eric, Sternbach, Daniel D., Kliewer, Steven A., Hansen, Barbara C., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic…”
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Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity by Sznaidman, Marcos L., Haffner, Curt D., Maloney, Patrick R., Fivush, Adam, Chao, Esther, Goreham, Donna, Sierra, Michael L., LeGrumelec, Christelle, Xu, H.Eric, Montana, Valerie G., Lambert, Millard H., Willson, Timothy M., Oliver, William R., Sternbach, Daniel D.

“…We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ)…”
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NEW SYNTHESIS OF L-FMAU FROM L-ARABINOSE by Sznaidman, Marcos L., Almond, Merrick R., Pesyan, Amir

“…A new synthesis of 2′-deoxy-2′-fluoro-5-methyl- β -L-arabinofuranosyl uracil (13, L-FMAU) was achieved in 10 steps from L-arabinose…”
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Guanine, Pyrazolo[3,4-d]pyrimidine, and Triazolo[4,5-d]pyrimidine (8-Azaguanine) Phosphonate Acyclic Derivatives as Inhibitors of Purine Nucleoside Phosphorylase by Beauchamp, Lilia M, Tuttle, Joel V, Rodriguez, Martha E, Sznaidman, Marcos L

“…Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]pyrimidines (8-azaguanines) are inhibitors of the enzyme purine…”
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Carbohydrate Cyclic Ketene Acetals by Sznaidman, Marcos L, Johnson, Stephen C, Crasto, Curtis, Hecht, Sidney M

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Synthesis of (−)-DAPD by Sznaidman, Marcos L., Du, Jinfa, Pesyan, Amir, Cleary, Darryl G., Hurley, Kevin P., Waligora, Frank, Almond, Merrick R.

“…A new synthesis of (−)-DAPD, suitable for large scale development, is described…”
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Regioselective synthesis of 9-substituted-8-azaguanines (5-amino-3-substituted-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one) by Sznaidman, Marcos L., Beauchamp, Lilia M.

“…By modifying previously described methods for the synthesis of 9‐substituted‐guanines from imidazoles, we have developed a new procedure for the regioselective…”
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Synthesis and antitumor activity of anthracycline disaccharide glycosides containing daunosamine by Horton, D, Priebe, W, Sznaidman, M L, Varela, O

“…Daunosamine, as its 4-O-acetyl-3-N-trifluoroacetyl glycosyl chloride derivative (1b), has been coupled alpha-L-glycosidically to the 3- and 4-mono-O-acetyl…”
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Steric and conformational effects in the dehalogenation of 2-halo sugar derivatives with tributylstannane by Horton, Derek, Priebe, Waldemar, Sznaidman, Marcos L.

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The antiinfluenza activity of pyrrolo[2,3- d]pyrimidines by Sznaidman, Marcos L., Meade, Eric A., Beauchamp, Lilia M., Russell, Stuart, Tisdale, Margaret

“…From a group of pyrrolo[2,3- d]pyrimidine compounds that have been screened against influenza virus, one derivative, 4-(3-piperidinyl benzylamino)-2-methyl-7…”
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Synthesis of 3-deoxyaldulosonic acid esters by one-carbon chain extension of glycal-derived lactone precursors by Horton, D, Issa, M, Priebe, W, Sznaidman, M L

“…A convenient preparative route is described for 3-deoxyaldulosonic acids. Glycal precursors are oxidatively converted into 2-deoxyaldonolactones, which react…”
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