Search Results - "Szkudlarek, Hanna"

Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function by Renard, Justine, Szkudlarek, Hanna J., Kramar, Cecilia P., Jobson, Christina E. L., Moura, Kyra, Rushlow, Walter J., Laviolette, Steven R.

“…Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in the…”
Get full text

The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions by Norris, Christopher, Szkudlarek, Hanna J., Pereira, Brian, Rushlow, Walter, Laviolette, Steven R.

“…The primary psychoactive compound in cannabis, Δ 9 -tetrahydrocannabinol (THC), is capable of producing bivalent rewarding and aversive affective states…”
Get full text

Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors by Szkudlarek, Hanna J, Desai, Sagar J, Renard, Justine, Pereira, Brian, Norris, Christopher, Jobson, Christina E L, Rajakumar, Nagalingam, Allman, Brian L, Laviolette, Steven R

“…The use of cannabis for therapeutic and recreational purposes is growing exponentially. Nevertheless, substantial questions remain concerning the potential…”
Get full text

l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry by De Felice, Marta, Renard, Justine, Hudson, Roger, Szkudlarek, Hanna J, Pereira, Brian J, Schmid, Susanne, Rushlow, Walter J, Laviolette, Steven R

“…Chronic adolescent exposure to Δ-9-tetrahydrocannabinol (THC) is linked to elevated neuropsychiatric risk and induces neuronal, molecular and behavioral…”
Get full text

Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats by Hudson, Roger, Norris, Christopher, Szkudlarek, Hanna J., Khan, Dinat, Schmid, Susanne, Rushlow, Walter J., Laviolette, Steven R.

“…Rationale Δ 9 -tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis and is responsible for cannabis-related neuropsychiatric side…”
Get full text

Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex by Uzuneser, Taygun C, Szkudlarek, Hanna J, Jones, Matthew J, Nashed, Mina G, Clement, Timothy, Wang, Hehe, Ojima, Iwao, Rushlow, Walter J, Laviolette, Steven R

“…Abstract The endocannabinoid (eCB) system represents a promising neurobiological target for novel anxiolytic pharmacotherapies. Previous clinical and…”
Get full text

THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways by Szkudlarek, Hanna J., Rodríguez-Ruiz, Mar, Hudson, Roger, De Felice, Marta, Jung, Tony, Rushlow, Walter J., Laviolette, Steven R.

“…•Intra-PFC infusion of THC and CBD lead to divergent behavioural and molecular profiles.•THC facilitates panic-like behaviour that can be prevented by…”
Get full text

Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system by Ng, Tsun Hay Jason, Sarikahya, Mohammed H, Hudson, Roger, Szkudlarek, Hanna J, Pérez-Valenzuela, Enzo, Uzuneser, Taygun C, Proud, Emma, Gummerson, Dana, Youssef, Miray, Machado, Madeline, Zhaksylyk, Kuralay, DeVuono, Marieka V, Chen, Chaochao, Yeung, Ken K-C, Rushlow, Walter J, Laviolette, Steven R

“…The majority of lifetime smokers begin using nicotine during adolescence, a critical period of brain development wherein neural circuits critical for mood,…”
Get full text

Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions by De Felice, Marta, Chen, Chaochao, Rodríguez-Ruiz, Mar, Szkudlarek, Hanna J, Lam, Michael, Sert, Selvi, Whitehead, Shawn N, Yeung, Ken K-C, Rushlow, Walter J, Laviolette, Steven R

“…Chronic exposure to Δ-9-tetrahydrocannabinol (THC) during adolescence is associated with long-lasting cognitive impairments and enhanced susceptibility to…”
Get full text

Prenatal THC exposure induces long-term, sex-dependent cognitive dysfunction associated with lipidomic and neuronal pathology in the prefrontal cortex-hippocampal network by Sarikahya, Mohammed H., Cousineau, Samantha L., De Felice, Marta, Szkudlarek, Hanna J., Wong, Karen K. W., DeVuono, Marieka V., Lee, Kendrick, Rodríguez-Ruiz, Mar, Gummerson, Dana, Proud, Emma, Ng, Tsun Hay Jason, Hudson, Roger, Jung, Tony, Hardy, Daniel B., Yeung, Ken K.-C., Schmid, Susanne, Rushlow, Walter, Laviolette, Steven R.

“…With increasing maternal cannabis use, there is a need to investigate the lasting impact of prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main…”
Get full text

Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus by Szkudlarek, Hanna J, Orlowska, Patrycja, Lewandowski, Marian H

“…The olivary pretectal nucleus (OPN) is a small midbrain structure responsible for pupil constriction in response to eye illumination. Previous…”
Get full text

Increased GABAergic Efficacy of Central Amygdala Projections to Neuropeptide S Neurons in the Brainstem During Fear Memory Retrieval by Jüngling, Kay, Lange, Maren D, Szkudlarek, Hanna J, Lesting, Jörg, Erdmann, Frank S, Doengi, Michael, Kügler, Sebastian, Pape, Hans-Christian

“…The canonical view on the central amygdala has evolved from a simple output station towards a highly organized microcircuitry, in which types of GABAergic…”
Get full text

The contribution of inner and outer retinal photoreceptors to infra-slow oscillations in the rat olivary pretectal nucleus by Orlowska-Feuer, Patrycja, Allen, Annette E., Storchi, Riccardo, Szkudlarek, Hanna J., Lewandowski, Marian H.

“…A subpopulation of olivary pretectal nucleus (OPN) neurons discharges action potentials in an oscillatory manner, with a period of approximately two minutes…”
Get full text

Retinal gap junctions are involved in rhythmogenesis of neuronal activity at remote locations – Study on infra-slow oscillations in the rat olivary pretectal nucleus by Orlowska-Feuer, Patrycja, Jeczmien-Lazur, Jagoda S, Szkudlarek, Hanna J, Lewandowski, Marian H

“…Highlights • Pharmacological blockade of retinal gap junctions with CBX or MFA leads to abolition of infra-slow oscillations in the OPN. • The effect of CBX on…”
Get full text

Components of action potential repolarization in cerebellar parallel fibres by Pekala, Dobromila, Baginskas, Armantas, Szkudlarek, Hanna J., Raastad, Morten

“…Key points The presynaptic action potential waveform was investigated in cerebellar parallel fibres from rats. The spike repolarization was composed of a fast…”
Get full text

The Impacts of Adolescent Cannabinoid Exposure on Striatal Anxiety- and Depressive-Like Pathophysiology Are Prevented by the Antioxidant N-Acetylcysteine by De Felice, Marta, Szkudlarek, Hanna J., Uzuneser, Taygun C., Rodríguez-Ruiz, Mar, Sarikahya, Mohammed H., Pusparajah, Mathusha, Galindo Lazo, Juan Pablo, Whitehead, Shawn N., Yeung, Ken K.-C., Rushlow, Walter J., Laviolette, Steven R.

“…Exposure to Δ9-tetrahydrocannabinol (THC) is an established risk factor for later-life neuropsychiatric vulnerability, including mood- and anxiety-related…”
Get full text

Thalamic Kv7 channels: pharmacological properties and activity control during noxious signal processing by Cerina, Manuela, Szkudlarek, Hanna J, Coulon, Philippe, Meuth, Patrick, Kanyshkova, Tatyana, Nguyen, Xuan Vinh, Göbel, Kerstin, Seidenbecher, Thomas, Meuth, Sven G, Pape, Hans‐Christian, Budde, Thomas

“…Background and Purpose The existence of functional Kv7 channels in thalamocortical (TC) relay neurons and the effects of the K+‐current termed M‐current (IM)…”
Get full text

Ultra-slow oscillatory neuronal activity in the rat olivary pretectal nucleus: comparison with oscillations within the intergeniculate leaflet by Szkudlarek, Hanna J., Herdzina, Olga, Lewandowski, Marian H.

“…Oscillations with a period between 1 and 4 min have been previously observed in many visual system structures. To determine whether similar oscillations in…”
Get full text

Anxiety and cognitive-related effects of [DELTA] .sup.9-tetrahydrocannabinol are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats by Hudson, Roger, Norris, Christopher, Szkudlarek, Hanna J, Khan, Dinat, Schmid, Susanne, Rushlow, Walter J, Laviolette, Steven R

“…Rationale [DELTA].sup.9-tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis and is responsible for cannabis-related neuropsychiatric…”
Get full text

Adolescent Nicotine Exposure Induces Dysregulation of Mesocorticolimbic Activity States and Depressive and Anxiety-like Prefrontal Cortical Molecular Phenotypes Persisting into Adulthood by Jobson, Christina L M, Renard, Justine, Szkudlarek, Hanna, Rosen, Laura G, Pereira, Brian, Wright, Daniel J, Rushlow, Walter, Laviolette, Steven R

“…Abstract Considerable evidence demonstrates strong comorbidity between nicotine dependence and mood and anxiety disorders. Nevertheless, the neurobiological…”
Get full text