Search Results - "Szilard, Rachel K."

A Genetic Map of the Response to DNA Damage in Human Cells by Olivieri, Michele, Cho, Tiffany, Álvarez-Quilón, Alejandro, Li, Kejiao, Schellenberg, Matthew J., Zimmermann, Michal, Hustedt, Nicole, Rossi, Silvia Emma, Adam, Salomé, Melo, Henrique, Heijink, Anne Margriet, Sastre-Moreno, Guillermo, Moatti, Nathalie, Szilard, Rachel K., McEwan, Andrea, Ling, Alexanda K., Serrano-Benitez, Almudena, Ubhi, Tajinder, Feng, Sumin, Pawling, Judy, Delgado-Sainz, Irene, Ferguson, Michael W., Dennis, James W., Brown, Grant W., Cortés-Ledesma, Felipe, Williams, R. Scott, Martin, Alberto, Xu, Dongyi, Durocher, Daniel

“…The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity, and gametogenesis. In order to provide an unbiased and global…”
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The shieldin complex mediates 53BP1-dependent DNA repair by Noordermeer, Sylvie M., Adam, Salomé, Setiaputra, Dheva, Barazas, Marco, Pettitt, Stephen J., Ling, Alexanda K., Olivieri, Michele, Álvarez-Quilón, Alejandro, Moatti, Nathalie, Zimmermann, Michal, Annunziato, Stefano, Krastev, Dragomir B., Song, Feifei, Brandsma, Inger, Frankum, Jessica, Brough, Rachel, Sherker, Alana, Landry, Sébastien, Szilard, Rachel K., Munro, Meagan M., McEwan, Andrea, Goullet de Rugy, Théo, Lin, Zhen-Yuan, Hart, Traver, Moffat, Jason, Gingras, Anne-Claude, Martin, Alberto, van Attikum, Haico, Jonkers, Jos, Lord, Christopher J., Rottenberg, Sven, Durocher, Daniel

“…53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini 1 , 2 . This…”
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Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7 by Wan, Leo C K, Maisonneuve, Pierre, Szilard, Rachel K, Lambert, Jean-Philippe, Ng, Timothy F, Manczyk, Noah, Huang, Hao, Laister, Rob, Caudy, Amy A, Gingras, Anne-Claude, Durocher, Daniel, Sicheri, Frank

“…The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N -threonylcarbamoyladenosine (t A), a universally conserved tRNA…”
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A substrate binding model for the KEOPS tRNA modifying complex by Beenstock, Jonah, Ona, Samara Mishelle, Porat, Jennifer, Orlicky, Stephen, Wan, Leo C. K., Ceccarelli, Derek F., Maisonneuve, Pierre, Szilard, Rachel K., Yin, Zhe, Setiaputra, Dheva, Mao, Daniel Y. L., Khan, Morgan, Raval, Shaunak, Schriemer, David C., Bayfield, Mark A., Durocher, Daniel, Sicheri, Frank

“…The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the…”
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The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer by Adam, Salomé, Rossi, Silvia Emma, Moatti, Nathalie, De Marco Zompit, Mara, Xue, Yibo, Ng, Timothy F, Álvarez-Quilón, Alejandro, Desjardins, Jessica, Bhaskaran, Vivek, Martino, Giovanni, Setiaputra, Dheva, Noordermeer, Sylvie M, Ohsumi, Toshiro K, Hustedt, Nicole, Szilard, Rachel K, Chaudhary, Natasha, Munro, Meagan, Veloso, Artur, Melo, Henrique, Yin, Shou Yun, Papp, Robert, Young, Jordan T F, Zinda, Michael, Stucki, Manuel, Durocher, Daniel

“…BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive…”
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A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres by Strecker, Jonathan, Stinus, Sonia, Caballero, Mariana Pliego, Szilard, Rachel K, Chang, Michael, Durocher, Daniel

“…DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking…”
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Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning by Ng, David, Pitcher, Graham M, Szilard, Rachel K, Sertié, Andréa, Kanisek, Marijana, Clapcote, Steven J, Lipina, Tatiana, Kalia, Lorraine V, Joo, Daisy, McKerlie, Colin, Cortez, Miguel, Roder, John C, Salter, Michael W, McInnes, Roderick R

“…The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic…”
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Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system by Wan, Leo C K, Mao, Daniel Y L, Neculai, Dante, Strecker, Jonathan, Chiovitti, David, Kurinov, Igor, Poda, Gennadiy, Thevakumaran, Neroshan, Yuan, Fang, Szilard, Rachel K, Lissina, Elena, Nislow, Corey, Caudy, Amy A, Durocher, Daniel, Sicheri, Frank

“…The universally conserved Kae1/Qri7/YgjD and Sua5/YrdC protein families have been implicated in growth, telomere homeostasis, transcription and the…”
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The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination by O'Donnell, Lara, Panier, Stephanie, Wildenhain, Jan, Tkach, Johnny M., Al-Hakim, Abdallah, Landry, Marie-Claude, Escribano-Diaz, Cristina, Szilard, Rachel K., Young, Jordan T.F., Munro, Meagan, Canny, Marella D., Kolas, Nadine K., Zhang, Wei, Harding, Shane M., Ylanko, Jarkko, Mendez, Megan, Mullin, Michael, Sun, Thomas, Habermann, Bianca, Datti, Alessandro, Bristow, Robert G., Gingras, Anne-Claude, Tyers, Michael D., Brown, Grant W., Durocher, Daniel

“…Genome integrity is jeopardized each time DNA replication forks stall or collapse. Here we report the identification of a complex composed of MMS22L (C6ORF167)…”
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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function by Juang, Yu-Chi, Landry, Marie-Claude, Sanches, Mario, Vittal, Vinayak, Leung, Charles C.Y., Ceccarelli, Derek F., Mateo, Abigail-Rachele F., Pruneda, Jonathan N., Mao, Daniel Y.L., Szilard, Rachel K., Orlicky, Stephen, Munro, Meagan, Brzovic, Peter S., Klevit, Rachel E., Sicheri, Frank, Durocher, Daniel

“…Ubiquitylation entails the concerted action of E1, E2, and E3 enzymes. We recently reported that OTUB1, a deubiquitylase, inhibits the DNA damage response…”
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Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine by Mao, Daniel Y.L., Neculai, Dante, Downey, Michael, Orlicky, Stephen, Haffani, Yosr Z., Ceccarelli, Derek F., Ho, Jenny S.L., Szilard, Rachel K., Zhang, Wei, Ho, Cynthia S., Wan, Leo, Fares, Christophe, Rumpel, Sigrun, Kurinov, Igor, Arrowsmith, Cheryl H., Durocher, Daniel, Sicheri, Frank

“…Kae1 is a universally conserved ATPase and part of the essential gene set in bacteria. In archaea and eukaryotes, Kae1 is embedded within the protein…”
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Control of Late Off-Center Cone Bipolar Cell Differentiation and Visual Signaling by the Homeobox Gene Vsx1 by Chow, Robert L., Volgyi, Bela, Szilard, Rachel K., Ng, David, McKerlie, Colin, Bloomfield, Stewart A., Birch, David G., McInnes, Roderick R., Nathans, Jeremy

“…Retinal bipolar cells are interneurons that transmit visual signals from photoreceptors to ganglion cells. Although the visual pathways mediated by bipolar…”
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A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions by Kanellis, Pamela, Gagliardi, Mark, Banath, Judit P, Szilard, Rachel K, Nakada, Shinichiro, Galicia, Sarah, Sweeney, Frederic D, Cabelof, Diane C, Olive, Peggy L, Durocher, Daniel

“…Genome instability is a hallmark of cancer cells. One class of genome aberrations prevalent in tumor cells is termed gross chromosomal rearrangements (GCRs)…”
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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition by Gallo, David, Young, Jordan T. F., Fourtounis, Jimmy, Martino, Giovanni, Álvarez-Quilón, Alejandro, Bernier, Cynthia, Duffy, Nicole M., Papp, Robert, Roulston, Anne, Stocco, Rino, Szychowski, Janek, Veloso, Artur, Alam, Hunain, Baruah, Prasamit S., Fortin, Alexanne Bonneau, Bowlan, Julian, Chaudhary, Natasha, Desjardins, Jessica, Dietrich, Evelyne, Fournier, Sara, Fugère-Desjardins, Chloe, Goullet de Rugy, Theo, Leclaire, Marie-Eve, Liu, Bingcan, Bhaskaran, Vivek, Mamane, Yael, Melo, Henrique, Nicolas, Olivier, Singhania, Akul, Szilard, Rachel K., Tkáč, Ján, Yin, Shou Yun, Morris, Stephen J., Zinda, Michael, Marshall, C. Gary, Durocher, Daniel

“…Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours…”
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The ubiquitous role of ubiquitin in the DNA damage response by Al-Hakim, Abdallah, Escribano-Diaz, Cristina, Landry, Marie-Claude, O’Donnell, Lara, Panier, Stephanie, Szilard, Rachel K., Durocher, Daniel

“…Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss…”
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Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX by Cheng, Benjamin, Yeung, ManTek, Szilard, Rachel K, Mendez, Megan, Robert, François, Galicia, Sarah, Bataille, Alain R, Durocher, Daniel, Bergeron, Maxime, Laramée, Louise, Jacques, Pierre-Étienne

“…H2AX phosphorylation is an early response to DNA damage and is mediated by the ATM/ATR kinases. By examining the genome-wide location of γ-H2A in wild type and…”
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Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome by Titorenko, V.I. (University of Alberta, Edmonton, Canada.), Smith, J.J, Szilard, R.K, Rachubinski, R.A

“…Pex mutants are defective in peroxisome assembly. In the pex20-1 mutant strain of the yeast Yarrowia lipolytica, the peroxisomal matrix protein thiolase is…”
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Enlarged peroxisomes are present in oleic acid-grown Yarrowia lipolytica overexpressing the PEX16 gene encoding an intraperoxisomal peripheral membrane peroxin by Eitzen, G.A. (University of Alberta, Edmonton, Canada.), Szilard, R.K, Rachubinski, R.A

“…Pex mutants of the yeast Yarrowia lipolytica are defective in peroxisome assembly. The mutant strain pex16-1 lacks morphologically recognizable peroxisomes…”
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Telomere Protection: An Act of God by Szilard, Rachel K., Durocher, Daniel

“…Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work…”
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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function by Juang, Yu-Chi, Landry, Marie-Claude, Sanches, Mario, Vittal, Vinayak, Leung, Charles, Ceccarelli, Derek F., Mateo, Abigail-Rachele F., Pruneda, Jonathan N., Mao, Dan, Szilard, Rachel K., Orlicky, Stephen, Munro, Meagan, Brzovic, Peter S., Klevit, Rachel E., Sicheri, Frank, Durocher, Daniel

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