Search Results - "Szilagyi, John T"

Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity by Szilagyi, John T, Vetrano, Anna M, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract Introduction The breast cancer resistance protein (BCRP/ ABCG2 ) is an efflux transporter in the placental barrier. By transporting chemicals from the…”
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Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase by Szilagyi, John T., Fussell, Karma C., Wang, Yun, Jan, Yi-Hua, Mishin, Vladimir, Richardson, Jason R., Heck, Diane E., Yang, Shaojun, Aleksunes, Lauren M., Laskin, Debra L., Laskin, Jeffrey D.

“…NADH cytochrome b5 reductase mediates electron transfer from NADH to cytochrome b5 utilizing flavin adenine dinucleotide as a redox cofactor. Reduced…”
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Perfluoroalkyl Substances (PFAS) and Their Effects on the Placenta, Pregnancy, and Child Development: a Potential Mechanistic Role for Placental Peroxisome Proliferator–Activated Receptors (PPARs) by Szilagyi, John T., Avula, Vennela, Fry, Rebecca C.

“…Purpose of Review This review summarizes studies highlighting perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy outcomes, and child…”
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Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations by Meakin, Cassandra J., Szilagyi, John T., Avula, Vennela, Fry, Rebecca C.

“…Exposure to inorganic arsenic (iAs) is a significant public health concern with individuals around the globe exposed to harmful levels through contaminated…”
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Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro by Szilagyi, John T, Freedman, Anastasia N, Kepper, Stewart L, Keshava, Arjun M, Bangma, Jackie T, Fry, Rebecca C

“…Abstract Per- and polyfluoroalkyl substances (PFAS) are used as industrial surfactants and chemical coatings for household goods such as Teflon. Despite…”
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New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing by Zavala, Jose, Freedman, Anastasia N, Szilagyi, John T, Jaspers, Ilona, Wambaugh, John F, Higuchi, Mark, Rager, Julia E

“…Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of…”
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Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone by Szilagyi, John T, Gorczyca, Ludwik, Brinker, Anita, Buckley, Brian, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract In the placenta, the breast cancer resistance protein (BCRP)/ABCG2 efflux transporter limits the maternal-to-fetal transfer of drugs and chemicals…”
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Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation by Meakin, Cassandra J, Martin, Elizabeth M, Szilagyi, John T, Nylander-French, Leena A, Fry, Rebecca C

“…Prenatal exposure to inorganic arsenic (iAs) has been associated with adverse developmental and reproductive outcomes. These outcomes may be tied to altered…”
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Regulation of renal calbindin expression during cisplatin‐induced kidney injury by George, Blessy, Szilagyi, John T., Joy, Melanie S., Aleksunes, Lauren M.

“…Since the discovery of calbindin release into the urine during renal injury, there has been growing interest in the utility of this protein as a biomarker of…”
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Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis by Szilagyi, John T., Composto-Wahler, Gabriella M., Joseph, Laurie B., Wang, Bingbing, Rosen, Todd, Laskin, Jeffrey D., Aleksunes, Lauren M.

“…The BCRP/ABCG2 efflux transporter is expressed on the membrane of placental syncytiotrophoblasts and protects the fetus from toxicant exposure…”
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Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium by Szilagyi, John T, Mishin, Vladimir, Heck, Diane E, Jan, Yi-Hua, Aleksunes, Lauren M, Richardson, Jason R, Heindel, Ned D, Laskin, Debra L, Laskin, Jeffrey D

“…Cytochrome P450 (CYP) enzymes mediate mixed-function oxidation reactions important in drug metabolism. The aromatic heterocyclic cation, diphenyleneiodonium…”
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Regulation of Renal Calbindin Expression During Cisplatin-Induced Kidney Injury: PO0225 by George, Blessy, Szilagyi, John T., Joy, Melanie S., Aleksunes, Lauren

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