Search Results - "Szewczyk, J W"

Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands by Dervan, Peter B, White, Sarah, Szewczyk, Jason W, Turner, James M, Baird, Eldon E

“…The design of synthetic ligands that read the information stored in the DNA double helix has been a long-standing goal at the interface of chemistry and…”
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Unaltered Graft Survival and Intragraft Lymphocytes Infiltration in the Cardiac Allograft of Cxcr3−/‐ Mouse Recipients by Kwun, J., Hazinedaroglu, S. M., Schadde, E., Kayaoglu, H. A., Fechner, J., Hu, H. Z., Roenneburg, D., Torrealba, J., Shiao, L., Hong, X., Peng, R., Szewczyk, J. W., Sullivan, K. A., DeMartino, J., Knechtle, S. J.

“…Previous studies showed that absence of chemokine receptor Cxcr3 or its blockade prolong mouse cardiac allograft survival. We evaluated the effect of the CXCR3…”
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Optimization of 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists by Henke, Brad R, Aquino, Christopher J, Birkemo, Larry S, Croom, Dallas K, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Queen, Kennedy L, Sherrill, Ronald G, Sugg, Elizabeth E, Suh, Edward M, Szewczyk, Jerzy W, Unwalla, Rayomand J, Yingling, Jeff, Willson, Timothy M

“…We previously described a series of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepine CCK-A agonists exemplified by compound 1 (GW 5823), which is the first…”
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Recognition of the DNA minor groove by pyrrole-imidazole polyamides : Comparison of desmethyl- and N-methylpyrrole by BREMER, R. E, SZEWCZYK, J. W, BAIRD, E. E, DERVAN, P. B

“…Polyamides consisting of N-methylpyrrole (Py), N-methylimidazole (Im), and N-methyl-3-hydroxypyrrole (Hp) are synthetic ligands that recognize predetermined…”
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Sequence Selectivity of 3-Hydroxypyrrole/Pyrrole Ring Pairings in the DNA Minor Groove by Urbach, Adam R, Szewczyk, Jason W, White, Sarah, Turner, James M, Baird, Eldon E, Dervan, Peter B

“…Hairpin polyamides containing the aromatic amino acids 3-hydroxypyrrole (Hp), pyrrole (Py), and imidazole (Im) are capable of discriminating all four…”
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Affinity and Specificity of Multiple Hydroxypyrrole/Pyrrole Ring Pairings for Coded Recognition of DNA by White, Sarah, Turner, James M, Szewczyk, Jason W, Baird, Eldon E, Dervan, Peter B

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Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides by Bremer, Ryan E, Wurtz, Nicholas R, Szewczyk, Jason W, Dervan, Peter B

“…Cell permeable synthetic ligands that bind to predetermined DNA sequences offer a chemical approach to gene regulation, provided inhibition of a broad range of…”
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A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA by KIELKOPF, C. L, WHITE, S, SZEWCZYK, J. W, TURNER, J. M, BAIRD, E. E, DERVAN, P. B, REES, D. C

“…Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates…”
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A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA by Kielkopf, Clara L., White, Sarah, Szewczyk, Jason W., Turner, James M., Baird, Eldon E., Dervan, Peter B., Rees, Douglas C.

“…Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates…”
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Alternative heterocycles for DNA recognition : An N-methylpyrazole/N-methylpyrrole pair specifies for A.T/T.A base pairs by NGUYEN, Doan H, SZEWCZYK, Jason W, BAIRD, Eldon E, DERVAN, Peter B

“…Side-by-side pairs of three five-membered rings, N-methylpyrrole (Py), N-methylimidazole (Im), and N-methylhydroxy-pyrrole (Hp), have been demonstrated to…”
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Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove by Kielkopf, C L, Bremer, R E, White, S, Szewczyk, J W, Turner, J M, Baird, E E, Dervan, P B, Rees, D C

“…Synthetic polyamides composed of three types of aromatic amino acids, N-methylimidazole (Im), N-methylpyrrole (Py) and N-methyl-3-hydroxypyrrole (Hp) bind…”
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SAR studies: Designing potent and selective LXR agonists by Szewczyk, Jason W., Huang, Shaei, Chin, Jayne, Tian, Jenny, Mitnaul, Lyndon, Rosa, Raymond L., Peterson, Larry, Sparrow, Carl P., Adams, Alan D.

“…Lead screening at Merck identified a potent, dual LXR/PPAR agonist. SAR optimization developed a series of LXR specific heterocyclic agonists having excellent…”
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Cooperative Triple-Helix Formation via a Minor Groove Dimerization Domain by Szewczyk, Jason W., Baird, Eldon E., Dervan, Peter B.

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