Search Results - "Szeto, John"

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review by Cory, Hannah, Passarelli, Simone, Szeto, John, Tamez, Martha, Mattei, Josiemer

“…This narrative mini- review summarizes current knowledge of the role of polyphenols in health outcomes-and non-communicable diseases specifically-and discusses…”
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From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization by Schlegel, Mark K, Janas, Maja M, Jiang, Yongfeng, Barry, Joseph D, Davis, Wendell, Agarwal, Saket, Berman, Daniel, Brown, Christopher R, Castoreno, Adam, LeBlanc, Sarah, Liebow, Abigail, Mayo, Tara, Milstein, Stuart, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Hyde, Sarah, Schofield, Sally, Szeto, John, Woods, Lauren Blair, Yilmaz, Vedat O, Manoharan, Muthiah, Egli, Martin, Charissé, Klaus, Sepp-Lorenzino, Laura, Haslett, Patrick, Fitzgerald, Kevin, Jadhav, Vasant, Maier, Martin A

“…Abstract Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA…”
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Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs by Schlegel, Mark K, Matsuda, Shigeo, Brown, Christopher R, Harp, Joel M, Barry, Joseph D, Berman, Daniel, Castoreno, Adam, Schofield, Sally, Szeto, John, Manoharan, Muthiah, Charissé, Klaus, Egli, Martin, Maier, Martin A

“…Abstract We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA…”
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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing by Jahns, Hartmut, Degaonkar, Rohan, Podbevsek, Peter, Gupta, Swati, Bisbe, Anna, Aluri, Krishna, Szeto, John, Kumar, Pawan, LeBlanc, Sarah, Racie, Tim, Brown, Christopher R, Castoreno, Adam, Guenther, Dale C, Jadhav, Vasant, Maier, Martin A, Plavec, Janez, Egli, Martin, Manoharan, Muthiah, Zlatev, Ivan

“…In order to achieve efficient therapeutic post-transcriptional gene-silencing mediated by the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs)…”
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Spinning the globe from west to east: A mixed-method study to examine the impact of pharmacists on immunization advocacy and delivery in Asia Pacific by Lum, Zheng Kang, Nguyen, Anhthai Doan, Szeto, John, Goode, Jean-Venable “Kelly” R., Han, Zhe, Lee, Joyce Yu-Chia

“…Global effort is key to prevent and control infections effectively. Whereas pharmacists’ involvement in the immunization neighborhood, collaborative effort to…”
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