Search Results - "Szentpétery, Zsófia"

Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib) by ELKIND, N. Barry, SZENTPETERY, Zsofia, KERI, György, NEMET, Katalin, SARKADI, Balazs, APATI, Agota, ÖZVEGY-LACZKA, Csilla, VARADY, György, UJHELLY, Olga, SZABO, Katalin, HOMOLYA, Laszlo, VARADI, Andras, BUDAY, Laszlo

“…Iressa (ZD1839, Gefitinib), used in clinics to treat non-small cell lung cancer patients, is a tyrosine kinase receptor inhibitor that leads to specific…”
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Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization by Cserepes, Judit, Szentpétery, Zsófia, Seres, László, Özvegy-Laczka, Csilla, Langmann, Thomas, Schmitz, Gerd, Glavinas, Hristos, Klein, Izabella, Homolya, László, Váradi, András, Sarkadi, Balázs, Elkind, N.Barry

“…The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation but no…”
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Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling by Szentpetery, Zsofia, Várnai, Peter, Balla, Tamas, Devreotes, Peter

“…Phosphoinositides are essential lipid regulators of trafficking and signaling pathways of all eukaryotic cells. Phosphatidylinositol 4-phosphate (PtdIns4P) is…”
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Phosphoinositide Signaling: New Tools and Insights by Balla, Tamas, Szentpetery, Zsofia, Kim, Yeun Ju

“…Tamas Balla , Zsofia Szentpetery and Yeun Ju Kim Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver…”
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Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides by Korzeniowski, Marek K., Popovic, Marko A., Szentpetery, Zsofia, Varnai, Peter, Stojilkovic, Stanko S., Balla, Tamas

“…Recent studies identified two main components of store-operated calcium entry (SOCE): the endoplasmic reticulum-localized Ca2+ sensor protein, STIM1, and the…”
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Dual roles for the Drosophila PI 4-kinase Four wheel drive in localizing Rab11 during cytokinesis by Polevoy, Gordon, Wei, Ho-Chun, Wong, Raymond, Szentpetery, Zsofia, Kim, Yeun Ju, Goldbach, Philip, Steinbach, Sarah K, Balla, Tamas, Brill, Julie A

“…Successful completion of cytokinesis relies on addition of new membrane, and requires the recycling endosome regulator Rab11, which localizes to the midzone…”
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Synergistic Activation of p21-activated Kinase 1 by Phosphatidylinositol 4,5-Bisphosphate and Rho GTPases by Malecka, Kimberly A., Szentpetery, Zsofia, Peterson, Jeffrey R.

“…Autoinhibited p21-activated kinase 1 (Pak1) can be activated in vitro by the plasma membrane-bound Rho GTPases Rac1 and Cdc42 as well as by the lipid…”
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A PH Domain in the Arf GTPase-activating Protein (GAP) ARAP1 Binds Phosphatidylinositol 3,4,5-Trisphosphate and Regulates Arf GAP Activity Independently of Recruitment to the Plasma Membranes by Campa, Fanny, Yoon, Hye-Young, Ha, Vi Luan, Szentpetery, Zsofia, Balla, Tamas, Randazzo, Paul A.

“…ARAP1 is a phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3)-dependent Arf GTPase-activating protein (GAP) with five PH domains that regulates…”
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Nucleotides and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter by Kern, András, Szentpétery, Zsófia, Liliom, Károly, Bakos, Eva, Sarkadi, Balázs, Váradi, András

“…The human ABC (ATP-binding cassette) transporter MRP1 (human multidrug-resistance-associated protein 1; ABCC1) is involved in the cellular extrusion of…”
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The Role of the Conserved Glycines of ATP-binding Cassette Signature Motifs of MRP1 in the Communication between the Substrate-binding Site and the Catalytic Centers by Szentpetery, Zsofia, Kern, Andras, Liliom, Karoly, Sarkadi, Balazs, Varadi, Andras, Bakos, Eva

“…A key element of the structural model of ABC-ATP-ases is the interaction of the two ABC domains. They complement each other's active sites in a way that the…”
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Functional Studies on the MRP1 Multidrug Transporter: Characterization of ABC-signature Mutant Variants by SZENTPETERY, Zs, SARKADI, B, BAKOS, E, VARADI, A

“…Background: MRP1 is a key multidrug resistance ATP-binding Cassette (ABC) transporter in tumor cells. A functionally important signature motif is conserved…”
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Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study by Szentpetery, Zsofia, Balla, Andras, Kim, Yeun Ju, Lemmon, Mark A, Balla, Tamas

“…Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] is a critically important regulatory phospholipid found in the plasma membrane of all eukaryotic cells…”
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Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα by Balla, Andras, Kim, Yeun Ju, Varnai, Peter, Szentpetery, Zsofia, Knight, Zachary, Shokat, Kevan M., Balla, Tamas

“…Type III phosphatidylinositol (PtdIns) 4-kinases (PI4Ks) have been previously shown to support plasma membrane phosphoinositide synthesis during phospholipase…”
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Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase by Jović, Marko, Kean, Michelle J, Szentpetery, Zsofia, Polevoy, Gordon, Gingras, Anne-Claude, Brill, Julie A, Balla, Tamas

“…Gaucher disease is a lysosomal storage disorder caused by a defect in the degradation of glucosylceramide catalyzed by the lysosomal enzyme…”
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Chemoanatomical separation of vibrissal trigeminal primary afferents in the rat: a special central representation of supraorbital vibrissae by Páli, Jenö, Baldauf, Zsolt A., Szentpétery, Zsófia, Szabó, Zoltán, Herczeg, Lívia, Görcs, Tamás. J.

“…A choleratoxin B subunit transganglionic labelling technique and NPY immunohistochemistry were applied in the rat to achieve the chemoanatomical separation of…”
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Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIα by Szentpetery, Zsofia, Szakacs, Gergely, Bojjireddy, Naveen, Tai, Andrew W., Balla, Tamas

“…Phosphatidylinositol 4-kinase type IIIa (PI4KIIIα) is one of four mammalian PI 4-kinases that catalyzes the first committed step in polyphosphoinositide…”
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Distinct roles of two lipid kinases in lysosomal transport of the Gaucher disease enzyme glucocerebrosidase by Jovic, Marko, Szentpetery, Zsofia, Kean, Michelle, Gingras, Anne‐Claude, Brill, Julie, Balla, Tamas

“…Lysosomal function in lipid metabolism relies on the efficient trafficking of glucocerebrosidase (GBA), a key enzyme in the breakdown of lysosomal…”
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Design of Drug-Resistant Alleles of Type-III Phosphatidylinositol 4-Kinases Using Mutagenesis and Molecular Modeling by Balla, Andras, Tuymetova, Galina, Toth, Balazs, Szentpetery, Zsofia, Zhao, Xiaohang, Knight, Zachary A, Shokat, Kevan, Steinbach, Peter J, Balla, Tamas

“…Molecular modeling and site directed mutagenesis were used to analyze the structural features determining the unique inhibitor sensitivities of type-III…”
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Design of Drug-Resistant Alleles of Type-III Phosphatidylinositol 4- Kinases Using Mutagenesis and Molecular Modeling by Balla, Andras, Tuymetova, Galina, Toth, Balazs, Szentpetery, Zsofia, Zhao, Xiaohang, Knight, Zachary A, Shokat, Kevan, Steinbach, Peter J, Balla, Tamas

“…Molecular modeling and site directed mutagenesis were used to analyze the structural features determining the unique inhibitor sensitivities of type- III…”
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Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha by Balla, Andras, Kim, Yeun Ju, Varnai, Peter, Szentpetery, Zsofia, Knight, Zachary, Shokat, Kevan M, Balla, Tamas

“…Type III phosphatidylinositol (PtdIns) 4-kinases (PI4Ks) have been previously shown to support plasma membrane phosphoinositide synthesis during phospholipase…”
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