Selective interaction of homophtalazine derivatives with morphine

Homophtalazines show specific binding sites in the nigrostriatal system and to find their target of action the interactions between these derivatives, nerisopam and girisopam, and chlorpromazine, chlordiazepoxide and morphine were assessed. The compounds did not influence the chlorpromazine induced...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 331; no. 2; pp. 175 - 183
Main Authors:	Fekete, Márton I.K, Horváth, Katalin, Kedves, Rita, Máté, Ildikó, Székely, József I, Szentkuti, Eszter
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 23-07-1997 Elsevier
Subjects:	Aggression - drug effects Analgesics, Opioid - pharmacology Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Anxiolytics Benzodiazepine Benzodiazepines - pharmacology Biological and medical sciences Catalepsy - chemically induced Catalepsy - psychology Dopamine receptor antagonist Drinking - drug effects Electroshock Homophtalazine (2,3-benzodiazepine) Male Medical sciences Mice Mice, Inbred Strains Morphine - pharmacology Motor Activity - drug effects Naloxone - pharmacology Narcotic Antagonists - pharmacology Neuropharmacology Opioid Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Reaction Time - drug effects Seizures - chemically induced Seizures - prevention & control Signal transduction Opioid Signal transduction Dopamine receptor antagonist Anxiolytics Benzodiazepine Homophtalazine (2,3-benzodiazepine) Rat Psychotropic Rodentia Central nervous system Molecular interaction Morphine Opiates Corpus striatum Tofisopam Narcotic analgesic Phthalazine derivatives Opiate receptor Vertebrata Biological fixation Mammalia Tranquillizer Mouse Girisopam Animal Benzodiazepine derivatives Mechanism of action Nigrostriatal pathway Brain (vertebrata)
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Summary:	Homophtalazines show specific binding sites in the nigrostriatal system and to find their target of action the interactions between these derivatives, nerisopam and girisopam, and chlorpromazine, chlordiazepoxide and morphine were assessed. The compounds did not influence the chlorpromazine induced decrease in motility and catalepsy, nor did they alter the antiaggressive and anticonvulsive action of chlordiazepoxide. However, nerisopam and girisopam augmented the agonist potency of morphine to induce catalepsy or analgesia; they also altered the opioid antagonist potency of naloxone. The naloxone-induced decrease in sucrose consumption in drinking water was augmented by nerisopam and girisopam. It is suggested that a possible target of action of homophtalazines is the opioid signal transduction.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(97)01056-X