Search Results - "Szendrei, G I"

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404 by Otvos, Jr, L, Feiner, L, Lang, E, Szendrei, G I, Goedert, M, Lee, V M

“…The microtubule-associated protein tau is hyperphosphorylated in the paired helical filaments (PHFs) of Alzheimer's disease. Immunological and direct chemical…”
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Activation of microglial cells by β-amyloid protein and interferon-γ by Meda, Lucia, Cassatella, Marco A, Szendrei, Gyorgyi I, Otvos, Laszlo, Baron, Pierluigi, Villalba, Martin, Ferrari, Davide, Rossi, Filippo

“…Alzheimer's disease is the most common cause of progressive intellectual failure. The lesions that develop, called senile plaques, are extracellular deposits…”
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Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location by Szendrei, G I, Lee, V M, Otvos, Jr, L

“…The major constituent of the paired helical filaments (PHFs) of Alzheimer's disease is the abnormally phosphorylated form of the microtubule-associated…”
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Comparative analysis of human and Dutch-type Alzheimer beta-amyloid peptides by infrared spectroscopy and circular dichroism by Fabian, H, Szendrei, G I, Mantsch, H H, Otvos, Jr, L

“…The 42 amino acid beta A4 peptide is the major constituent of the senile plaques, one of the hallmark neuropathological lesions of Alzheimer's disease. While…”
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Human and rodent Alzheimer β‐amyloid peptides acquire distinct conformations in membrane‐mimicking solvents by OTVOS, Laszlo, SZENDREI, Gyorgyi I., LEE, Virginia M.‐Y., MANTSCH, Henry H.

“…The major constituent of senile plaques (one of the hallmark lesions of Alzheimer's disease) is a 42(43)‐amino‐acid polypeptide, termed the A4 or β‐amyloid…”
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Spectroscopic evidence that monoclonal antibodies recognize the dominant conformation of medium-sized synthetic peptides by Lang, E, Szendrei, G I, Lee, V M, Otvos, Jr, L

“…Spectroscopic methods have amply documented that small- and medium-sized peptides tend to assume unordered conformations in water. The conformational…”
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Synthetic analogues of conantokin-G: NMDA antagonists acting through a novel polyamine-coupled site by Zhou, L M, Szendrei, G I, Fossom, L H, Maccecchini, M L, Skolnick, P, Otvos, Jr, L

“…Conantokin-G (con-G) is a 17-amino-acid polypeptide that acts as an N-methyl-D-aspartate (NMDA) antagonist. This action has been attributed to a specific but…”
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Enzyme-linked immunosorbent assay of peptides by Otvös, Jr, L, Szendrei, G I

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β-Amyloid(25–35) induces the production of interleukin-8 from human monocytes by Meda, Lucia, Bonaiuto, Corrada, Szendrei, Gyorgyi I., Ceska, Miroslav, Rossi, Filippo, Cassatella, marco A.

“…In an effort to unravel some of the cellular actions of gb-amyloid protein (Aβ), we investigated its effects on interleukin-8 (IL-8) production from human…”
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Glycosylation of synthetic T helper cell epitopic peptides influences their antigenic potency and conformation in a sugar location-specific manner by Otvos, Jr, L, Urge, L, Xiang, Z Q, Krivulka, G R, Nagy, L, Szendrei, G I, Ertl, H C

“…The immunodominant T helper cell epitopes 31D and VF13N of rabies virus nucleoprotein and glycoprotein, respectively, correspond to peptide sequences…”
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Reversible beta-pleated sheet formation of a phosphorylated synthetic tau peptide by Lang, E, Szendrei, G I, Elekes, I, Lee, V M, Otvos, Jr, L

“…Serine416 of human tau protein is believed to be phosphorylated in Alzheimer neurofibrillary tangles. We synthesized a fragment of tau, consisting of amino…”
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Aspartate‐Bond Isomerization Affects the Major Conformations of Synthetic Peptides by Szendrei, Gyorgyi I., Fabian, Heinz, Mantsch, Henry H., Lovas, Sandor, Nyéki, Olga, Schön, Istvan, Otvos, Laszlo

“…The aspartic acid bond changes to an β‐aspartate bond frequently as a side‐reaction during peptide synthesis and often as a post‐translational modification of…”
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Synthetic post‐translationally modified human Aβ peptide exhibits a markedly increased tendency to form β‐pleated sheets in vitro by FABIAN, Heinz, SZENDREI, Gyorgyi I., MANTSCH, Henry H., GREENBERG, Barry D., ÖTVÖS, Laszlo

“…The β‐amyloid peptide (Aβ) is the major constituent of senile plaques, one of the hallmark neuropathological lesions of Alzheimer's disease. Recently a…”
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The effects of aspartic acid-bond isomerization on in vitro properties of the amyloid beta-peptide as modeled with N-terminal decapeptide fragments by Szendrei, G I, Prammer, K V, Vasko, M, Lee, V M, Otvos, Jr, L

“…The 42-amino acid A beta, the major constituent of the senile plaque deposits of the brains of Alzheimer's disease patients, exhibits a high degree of…”
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Impact of point mutations and amino acid modifications on the structure and stability of peptides and proteins probed by FT-IR spectroscopy by Fabian, H., Naumann, D., Otvos, L., Schultz, C., Backmann, J., Szendrei, G.I., Hahn, U., Saenger, W., Mantsch, H.H.

“…IR spectroscopy was used to study the impact of amino acid modifications on the association behaviour of β-amyloid peptides (βA4 peptides) and to investigate…”
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Comparative Virtual and Experimental High-Throughput Screening for Glycogen Synthase Kinase-3β Inhibitors by Polgár, Tímea, Baki, Andrea, Szendrei, Györgyi I, Keserűu, György M

“…Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase that has recently emerged as a key target for neurodegenerative diseases and diabetes. As an…”
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Solid-phase synthesis of 2,6- and 2,7-diamino-4(3 H)-quinazolinones via palladium-catalyzed amination by Wéber, Csaba, Demeter, Ádám, Szendrei, Györgyi I., Greiner, István

“…A new procedure for the solid-phase synthesis of 2,6- and 2,7-diamino-4(3 H)-quinazolinones is described. The method involves coupling of 2,4,6- and…”
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Solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines by Wéber, Csaba, Bielik, Attila, Demeter, Ádám, Borza, István, Szendrei, Györgyi I., Keserű, György M., Greiner, István

“…A new method for the solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound…”
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Novel solid-phase synthesis of 2,6-disubstituted 4(3 H)-quinazolinones for combinatorial library generation by Wéber, Csaba, Bielik, Attila, Szendrei, Györgyi I, Greiner, István

“…A novel procedure for the synthesis of 6-alkoxy-2-amino-4(3 H)-quinazolinones from 2,4-dichloro-6-hydroxyquinazoline, amines and alcohols using Wang resin is…”
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Solid-phase synthesis of an N-(phenylalkyl)cinnamide library via Horner-Wadsworth-Emmons reaction by WEBER, Csaba, BIELIK, Attila, SZENDREI, Györgyi I, KESERU, György M, GREINER, Istvan

“…A readily automated solid-phase approach to the synthesis of diverse N-(phenylalkyl)cinnamides, analogues of the NR2B antagonist 2, is described. The procedure…”
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