Search Results - "Szeliga, Jan"

DNA Adduct Formation by Polycyclic Aromatic Hydrocarbon Dihydrodiol Epoxides by Szeliga, Jan, Dipple, Anthony

“…Classically, active metabolites of chemical carcinogens were identified by isolating various metabolites produced in experimental animals and determining which…”
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Improved Synthesis of a Macrocyclic Peptide-Like C5aR Antagonist for Intravenous Applications by Feng, Yiqing, Liang, Sidney, Langille, Jonathan, Pierce, Betsy S., Chung, SeungWon, Szeliga, Jan, Wilcox, Glenn, Simonds, Paul, Farley, Kathleen A., Li, Bryan, Garcia-Irizarry, Carmen, Jones, Peter, Lira, Ricardo

“…A multigram scale synthetic procedure for the preparation of a complex and polar macrocyclic peptidic C5aR antagonist is described. The route was developed…”
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Enabled Process To Synthesize Monobactam 1 for Early Development by Tao, Yong, Lall, Manjinder S, Boyles, David C, Lilley, Susan C, Pattavina, Sebastian D, Rafka, Robert J, Sitter, Barbara J, Stewart, Andrew Morgan, Szeliga, Jan, Weisenburger, Gerald A

“…An efficient process to synthesize Monobactam 1 from intermediates 2, 3, and 4 was developed. The process was initially enabled to deliver 500 g of 1 for…”
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Mutational Spectra for 5,6-Dimethylchrysene 1,2-Dihydrodiol 3,4-Epoxides in the supF Gene of pSP189 by Page, John E, Szeliga, Jan, Amin, Shantu, Hecht, Stephen S, Dipple, Anthony

“…Dihydrodiol epoxides from 5,6-dimethylchrysene exhibit properties similar to those of fjord region-containing hydrocarbon derivatives in that they react…”
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Modified Chelation-Controlled Reduction of an N-Acryloyloxazolidin-2-one by Connolly, Terrence J, Ding, Zhixian, Gong, Yumin, MacEwan, Michael F, Szeliga, Jan, Alimardanov, Asaf

“…A key step in the synthesis of an optically active aminoalcohol-containing active pharmaceutical ingredient (API) involved the diasteroselective reduction of a…”
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Design and synthesis of HCV agents with sequential triple inhibitory potentials by Zhu, Tianmin, Fawzi, Mahdi B., Flint, Michael, Kong, Fangming, Szeliga, Jan, Tsao, Russ, Howe, Anita Y.M., Pan, Weitao

“…The union of HCV-796, a potent selective HCV NS5B polymerase inhibitor, and Ribavirin, a molecule with activities against a wide spectrum of viruses, resulted…”
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Quantitative reactions of anti 5,9-dimethylchrysene dihydrodiol epoxide with DNA and deoxyribonucleotides by Szeliga, Jan, Amin, Shantu

“…Native as well as denatured calf thymus DNA, deoxyguanylic and deoxyadenylic acid, respectively, were reacted with the racemic anti 5,9-dimethylchrysene…”
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Seasonal variation of aromatic DNA adducts in human lymphocytes and granulocytes by Grzybowska, E, Hemminki, K, Szeliga, J, Chorazy, M

“…DNA adducts were measured by 32P-postlabelling in lymphocytes and granulocytes of 75 healthy men exposed occupationally and environmentally to high…”
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Application of mixed mobile phases and a step gradient method in capillary electrochromatography for the separation of isomeric polycyclic aromatic hydrocarbon-deoxyribonucleoside adduct mixtures prepared in vitro by Ding, Jianmei, Szeliga, Jan, Dipple, Anthony, Vouros, Paul

“…Capillary electrochromatography (CEC) was used for the analysis of mixtures of neutral isomeric compounds derived from the reaction of carcinogenic hydrocarbon…”
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Ambient Air Pollutants in Upper Silesia: Partial Chemical Composition and Biological Activity by Chorazy, Mieczyslaw, Szeliga, Jan, Strozyk, Malgorzata, Cimander, Bernard

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Ambient Air Pollutants in Upper Silesia: Partial Chemical Composition and Biological Activity by Chorąży, Mieczysław, Szeliga, Jan, Stróżyk, Małgorzata, Cimander, Bernard

“…The air monitoring system in Upper Silesia has provided abundant data on airborne pollutants. Air quality in this region is bad: a concentration of several…”
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Reactions of Dihydrodiol Epoxides of 5-Methylchrysene and 5,6-Dimethylchrysene with DNA and Deoxyribonucleotides by Szeliga, Jan, Amin, Shantu, Zhang, Fang-Jie, Harvey, Ronald G

“…Both syn and anti dihydrodiol epoxides from 5-methylchrysene (5-MCDE) and 5,6-dimethylchrysene (5,6-DMCDE) were reacted under the same conditions with native…”
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Characterization of DNA Adducts Formed by anti-Benzo[g]chrysene 11,12-Dihydrodiol 13,14-Epoxide by Szeliga, Jan, Page, John E, Hilton, Bruce D, Kiselyov, Alexander S, Harvey, Ronald G, Dunayevskiy, Yuriy M, Vouros, Paul, Dipple, Anthony

“…The anti-11,12-dihydrodiol 13,14-epoxide of benzo[g]chrysene, a fjord-region-containing hydrocarbon, was found to react with DNA in vitro to yield, as the…”
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Reaction with DNA and Mutagenic Specificity of syn-Benzo[g]chrysene 11,12-Dihydrodiol 13,14-Epoxide by Szeliga, Jan, Lee, Hongmee, Harvey, Ronald G, Page, John E, Ross, Helen L, Routledge, Michael N, Hilton, Bruce D, Dipple, Anthony

“…The spectroscopic characterization of purine deoxyribonucleoside adducts derived from the fjord-region syn-benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide and…”
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Characterization of DNA Adducts Formed by the Four Configurationally Isomeric 5,6-Dimethylchrysene 1,2-Dihydrodiol 3,4-Epoxides by Szeliga, Jan, Hilton, Bruce D, Chmurny, Gwendolyn N, Krzeminski, Jacek, Amin, Shantu, Dipple, Anthony

“…The DNA adducts formed from the racemic syn and anti dihydrodiol epoxides of 5,6-dimethylchrysene were characterized through various spectroscopic methods…”
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DNA Adducts Formed by the Fjord-Region Dihydrodiol Epoxide of Benzo[S]Picene by Szeliga, Jan, Zhang, Fang-jie, Harvey, Ronald G., Dipple, Anthony

“…Anti benzo[s]picene 9,10-dihydrodiol 11,12-epoxide was reacted with calf thymus DNA and with its constituent deoxyribonucleotides. The origin of DNA adducts…”
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