Search Results - "Szekerke, M."

Carrier design: Synthesis and conformational studies of poly (L-lysine) based branched polypeptides with hydroxyl groups in the side chains by Mezö, G., Kajtár, J., Nagy, I., Szekerke, M., Hudecz, F.

“…In the present study the development of a new series of branched polypeptides that contain hydroxyl groups in side chains is reported. Serine or threonine were…”
Get full text

Influence of carrier on biodistribution and in vitro cytotoxicity of methotrexate-branched polypeptide conjugates by Hudecz, F, Clegg, J. A, Kajtar, J, Embleton, M. J, Pimm, M. V, Szekerke, M, Baldwin, R. W

“…Methotrexate (MTX) has been conjugated to various structurally related, synthetic, branched polypeptides containing a poly(L-Lys) backbone by the aid of…”
Get full text

Carrier design: conformational studies of amino acid (X) and oligopeptide (X-DL-Alam) substituted poly (L-lysine) by Mezö, G, Kajtár, J, Hudecz, F, Szekerke, M

“…The present study was undertaken to examine the influence of the reversal of the side-chain sequential order on the conformation of branched polypeptides. At…”
Get more information

Synthesis, conformation, biodistribution and in vitro cytotoxicity of daunomycin-branched polypeptide conjugates by Hudecz, Ferenc, Clegg, J. A., Kajtar, J., Embleton, M. J., Szekerke, M., Baldwin, R. W.

“…Daunomycin has been attached to various structurally related synthetic branched polypeptides with a polylysine backbone, using its acid-labile cis-aconityl…”
Get full text

Carrier design: biodistribution of branched polypeptides with a poly(L-lysine) backbone by Clegg, J. A, Hudecz, F, Mezo, G, Pimm, M. V, Szekerke, M, Baldwin, R. W

“…The biodistribution has been examined in mice of a range of synthetic branched polypeptides which are based on a polylysine backbone but which differ in ionic…”
Get full text

Antitumour effect of a gonadotropin-releasing-hormone antagonist (MI-1544) and its conjugate on human breast cancer cells and their xenografts by VINCZE, B, PALYI, I, DAUBNER, D, KALNAY, A, MEZÖ, G, HUDECZ, F, SZEKERKE, M, TEPLAN, I, MEZÖ, I

“…Our gonadotropin-releasing hormone (GnRH) antagonist analogue MI-1544 ([Ac-D-Trp1,3,D-Cpa2,D-Lys6,D-Ala10]GnRH) was developed as a potential contraceptive…”
Get full text

Proceedings: Studies related to the carrier principle in the design of cytotoxic drugs by Szekerke, M

Get full text

Synthesis and functional studies of tuftsin analogs containing isopeptide bond by Mezö, G, Szekerke, M, Sármay, G, Gergely, J

“…In the present paper a new approach is reported, to increase the resistance of tuftsin toward enzymatic cleavage by the introduction of an isopeptide bond into…”
Get more information

The influence of the side-chain sequence on the structure-activity correlations of immunomodulatory branched polypeptides. Synthesis and conformational analysis of new model polypeptides by Mezö, G, Hudecz, F, Kajtár, J, Szókán, G, Szekerke, M

“…New branched polypeptides were synthesized for a detailed study of the influence of the side-chain structure on the conformation and biological properties. The…”
Get more information

Structural characteristics influencing the carrier function of synthetic branched polypeptides based on poly[Lys-(DL-Ala)3)]backbone by Rajnavölgyi, E, Lányi, A, Hudecz, F, Kurucz, I, Kiss, K, László, G, Szekerke, M, Gergely, J

“…Effective carrier function of selected representatives of new branched polypeptides covalently coupled with the synthetic monovalent hapten, oxazolone was…”
Get more information

Interaction of the antitumour drug 4′-(9-acridinyIamino)-methanesulfon-m-anisidine.HCl (m-AMSA) with nucleic acids by Hudecz, F., Kajtár, J., Szekerke, M.

“…The interaction of AMSA with nucleic acids was studied by several techniques. Melting temperature and CD studies equally suggest that AMSA-binding is…”
Get full text

Investigation of drug-protein interactions and the drug-carrier concept by the use of branched polypeptides as model systems. Synthesis and characterization of the model peptides by Hudecz, Ferenc, Szekerke, Mária

“…Synthesis of branched polypeptides with a new design of variations in surface topography is described. The side chains of the poly(Lys-(DL-Ala m )) were…”
Get full text

Potentiation of the defective monocyte chemotaxis in Hodgkin's disease by in vitro tuftsin treatment by Lukács, K, Berényi, E, Kávai, M, Szegedi, G, Szekerke, M

“…In vitro pre-incubation of monocytes derived from patients with Hodgkin's disease with tuftsin (50 micrograms/ml) significantly restored the deficient…”
Get full text

A new approach to the study of the contribution of peptide carriers to antitumour activity; binding of the peptide moiety to human serum albumin by Szekerke, M., Horváth, M., Érchegyi, J.

Get full text

The use of macromolecules as carriers of cytotoxic groups (part I) conjugates of nitrogen mustards with proteins, polypeptidyl proteins and polypeptides by Szekerke, M, Wade, R, Whisson, M E

Get full text

The use of macromolecules as carriers of cytotoxic groups (part II) nitrogen mustard--protein complexes by Szekerke, M, Wade, R, Whisson, M E

Get full text

Interaction of homopyrimidazole derivatives with biopolymers. II. Binding to chemically modified albumins; attempt to correlate chemical structure and binding affinity by Szekerke, M, Horváth, M

“…The degree of human serum albumin (HSA) binding for 16 different homopyrimidazole derivatives has been studied. The positions of UV absorption maximum, the…”
Get more information

Interaction of homopyrimidazole derivatives with biopolymers. I. Binding of MZ 144, a new potent analgesic to human serum albumin by Szekerke, M, Horváth, M

“…The binding of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydro-homopyrimidazolium-methyl-sulfate (MZ 144, Probon) to human serum albumin (HSA) has been…”
Get more information

Immunomodulatory effect of synthetic branched polypeptides. II by Gaál, D, Hudecz, F, Kovács, A L, Szekerke, M

“…A comparative investigation of various polypeptides was carried out in order to elucidate structure-activity correlations. The immunoadjuvant properties of the…”
Get more information

Immunomodulatory effect of synthetic branched polypeptides I by Gaál, D, Hudecz, F, Szekerke, M

“…The immunomodulatory potential of poly-(Lys-[Leu-poly-DL-Ala]) (LAK) (Lys:Ala:Leu = 1:3:0.7) as the first prototype of a series of new branched polypeptides…”
Get more information