Search Results - "Szekeres, Philip G."

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates by Falcon, Benjamin, Cavallini, Annalisa, Angers, Rachel, Glover, Sarah, Murray, Tracey K., Barnham, Luanda, Jackson, Samuel, O'Neill, Michael J., Isaacs, Adrian M., Hutton, Michael L., Szekeres, Philip G., Goedert, Michel, Bose, Suchira

“…Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer…”
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Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau by Jackson, Samuel J, Kerridge, Caroline, Cooper, Jane, Cavallini, Annalisa, Falcon, Benjamin, Cella, Claire V, Landi, Alessia, Szekeres, Philip G, Murray, Tracey K, Ahmed, Zeshan, Goedert, Michel, Hutton, Michael, O'Neill, Michael J, Bose, Suchira

“…The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of…”
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The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids by Brown, Andrew J, Goldsworthy, Susan M, Barnes, Ashley A, Eilert, Michelle M, Tcheang, Lili, Daniels, Dion, Muir, Alison I, Wigglesworth, Mark J, Kinghorn, Ian, Fraser, Neil J, Pike, Nicholas B, Strum, Jay C, Steplewski, Klaudia M, Murdock, Paul R, Holder, Julie C, Marshall, Fiona H, Szekeres, Philip G, Wilson, Shelagh, Ignar, Diane M, Foord, Steve M, Wise, Alan, Dowell, Simon J

“…GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in…”
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Neuromedin U and Its Receptors: Structure, Function, and Physiological Roles by Brighton, Paul J, Szekeres, Philip G, Willars, Gary B

“…N euro m edin U (NmU) is a structurally highly conserved neuropeptide. It is ubiquitously distributed, with highest levels found in the gastrointestinal tract…”
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The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids by Briscoe, Celia P, Tadayyon, Mohammad, Andrews, John L, Benson, William G, Chambers, Jon K, Eilert, Michelle M, Ellis, Catherine, Elshourbagy, Nabil A, Goetz, Aaron S, Minnick, Dana T, Murdock, Paul R, Sauls, Jr, Howard R, Shabon, Usman, Spinage, Lisa D, Strum, Jay C, Szekeres, Philip G, Tan, Kong B, Way, James M, Ignar, Diane M, Wilson, Shelagh, Muir, Alison I

“…GPR40 is a member of a subfamily of homologous G protein-coupled receptors that include GPR41 and GPR43 and that have no current function or ligand ascribed…”
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Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid by Wise, Alan, Foord, Steven M, Fraser, Neil J, Barnes, Ashley A, Elshourbagy, Nabil, Eilert, Michelle, Ignar, Diane M, Murdock, Paul R, Steplewski, Klaudia, Green, Andrew, Brown, Andrew J, Dowell, Simon J, Szekeres, Philip G, Hassall, David G, Marshall, Fiona H, Wilson, Shelagh, Pike, Nicholas B

“…Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia producing a desirable normalization of a range of cardiovascular…”
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AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1 by Muir, A I, Chamberlain, L, Elshourbagy, N A, Michalovich, D, Moore, D J, Calamari, A, Szekeres, P G, Sarau, H M, Chambers, J K, Murdock, P, Steplewski, K, Shabon, U, Miller, J E, Middleton, S E, Darker, J G, Larminie, C G, Wilson, S, Bergsma, D J, Emson, P, Faull, R, Philpott, K L, Harrison, D C

“…A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the rat orphan receptor GPR54, was cloned from a human brain cDNA library…”
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GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function by MOORE, Darren J, MURDOCK, Paul R, WATSON, Jeannette M, FAULL, Richard L. M, WALDVOGEL, Henry J, SZEKERES, Philip G, WILSON, Shelagh, FREEMAN, Katie B, EMSON, Piers C

“…We have recently shown that UDP-glucose, and some related UDP-sugars, are potent agonists of the novel G protein-coupled receptor GPR105 (recently re-named…”
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Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells by Aiyar, Nambi, Disa, Jyoti, Foley, James J, Buckley, Peter T, Wixted, William E, Pullen, Mark, Shabon, Usman, Dul, Edward, Szekeres, Philip G, Elshourbagy, Nabil A, Sarau, Henry M, Appelbaum, Edward, Bolaky, Jane

“…Neuromedin U (NmU) is a smooth muscle contracting peptide. Recently, two G-protein-coupled receptors for NmU (NmU1R and NmU2R) have been cloned having…”
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Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor by Elshourbagy, N A, Ames, R S, Fitzgerald, L R, Foley, J J, Chambers, J K, Szekeres, P G, Evans, N A, Schmidt, D B, Buckley, P T, Dytko, G M, Murdock, P R, Milligan, G, Groarke, D A, Tan, K B, Shabon, U, Nuthulaganti, P, Wang, D Y, Wilson, S, Bergsma, D J, Sarau, H M

“…Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain…”
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Pharmacological manipulation of Hsp90 and its effects on phospho-tau species in an AD-relevant cell-based model by Glover, Sarah J, Wolak, Joanna, Szekeres, Philip G

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The Discovery of a Selective, Small Molecule Agonist for the Mas-Related Gene X1 Receptor by Wroblowski, Berthold, Wigglesworth, Mark J, Szekeres, Philip G, Smith, Graham D, Rahman, Shahzad S, Nicholson, Neville H, Muir, Alison I, Hall, Adrian, Heer, Jag P, Garland, Stephen L, Coates, William J

“…The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain…”
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Neuromedin U Is a Potent Agonist at the Orphan G Protein-coupled Receptor FM3 by Szekeres, Philip G., Muir, Alison I., Spinage, Lisa D., Miller, Jane E., Butler, Sharon I., Smith, Angela, Rennie, Gillian I., Murdock, Paul R., Fitzgerald, Laura R., Wu, Hsiao-ling, McMillan, Lynette J., Guerrera, Stephanie, Vawter, Lisa, Elshourbagy, Nabil A., Mooney, Jeffrey L., Bergsma, Derk J., Wilson, Shelagh, Chambers, Jon K.

“…Neuromedins are a family of peptides best known for their contractile activity on smooth muscle preparations. The biological mechanism of action of neuromedin…”
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Dramatic increases in phosphorylation of tau only on specific epitopes correlates with decline in motor function in aged P301S mice by Szekeres, Philip G, Glover, Sarah J, Lakics, Viktor, Cella, Claire V, Purcell, Robert, Murray, Tracey K, Cavallini, Annalisa, Lavenir, Isabelle, Goedert, Michel, Davies, Peter, Hutton, Michael L, O'Neill, Michael J

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Characterization of the binding of [125I]‐human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor by Langmead, Christopher J, Szekeres, Philip G, Chambers, Jonathan K, Ratcliffe, Steven J, Jones, Declan N C, Hirst, Warren D, Price, Gary W, Herdon, Hugh J

“…GPR10 is a novel G‐protein coupled receptor that is the human orthologue of rat Unknown Hypothalamic Receptor‐1 (UHR‐1). Human prolactin‐releasing peptide…”
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Neuroreplacement, growth factor, and small molecule neurotrophic approaches for treating Parkinson's disease by O'Neill, Michael J, Messenger, Marcus J, Lakics, Viktor, Murray, Tracey K, Karran, Eric H, Szekeres, Philip G, Nisenbaum, Eric S, Merchant, Kalpana M

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Functional assays for identifying ligands at orphan G protein-coupled receptors by Szekeres, Philip G

“…The superfamily of G protein-coupled receptors (GPCRs; 7TMs) is one of the largest families of genes identified in humans, and has a proven history of being an…”
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The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line by Szekeres, P G, Koenig, J A, Edwardson, J M

“…The molecular mechanisms underlying the internalization of G protein-coupled receptors are still poorly understood. Normally agonists but not antagonists cause…”
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P3‐184: Pharmacological manipulation of Hsp90 and its effects on phospho‐tau species in an AD‐relevant cell‐based model by Glover, Sarah J., Wolak, Joanna, Szekeres, Philip G.

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P1‐348: Dramatic increases in phosphorylation of tau only on specific epitopes correlates with decline in motor function in aged P301S mice by Szekeres, Philip G., Glover, Sarah J., Lakics, Viktor, Cella, Claire V., Purcell, Robert, Murray, Tracey K., Cavallini, Annalisa, Lavenir, Isabelle, Goedert, Michel, Davies, Peter, Hutton, Michael L., O'Neill, Michael J.

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