Search Results - "Szeder, Bálint"

The effects of mutant Ras proteins on the cell signalome by Takács, Tamás, Kudlik, Gyöngyi, Kurilla, Anita, Szeder, Bálint, Buday, László, Vas, Virag

“…The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several…”
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Cellular Internalization and Inhibition Capacity of New Anti-Glioma Peptide Conjugates: Physicochemical Characterization and Evaluation on Various Monolayer- and 3D-Spheroid-Based in Vitro Platforms by Baranyai, Zsuzsa, Biri-Kovács, Beáta, Krátký, Martin, Szeder, Bálint, Debreczeni, Márta L, Budai, Johanna, Kovács, Bence, Horváth, Lilla, Pári, Edit, Németh, Zsuzsanna, Cervenak, László, Zsila, Ferenc, Méhes, Előd, Kiss, Éva, Vinšová, Jarmila, Bősze, Szilvia

“…Most therapeutic agents used for treating brain malignancies face hindered transport through the blood–brain barrier (BBB) and poor tissue penetration. To…”
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Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis by Kudlik, Gyöngyi, Takács, Tamás, Radnai, László, Kurilla, Anita, Szeder, Bálint, Koprivanacz, Kitti, Merő, Balázs L, Buday, László, Vas, Virag

“…Scaffold proteins are typically thought of as multi-domain "bridging molecules." They serve as crucial regulators of key signaling events by simultaneously…”
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EGF Regulates the Interaction of Tks4 with Src through Its SH2 and SH3 Domains by Dülk, Metta, Szeder, Bálint, Glatz, Gábor, Merő, Balázs L, Koprivanacz, Kitti, Kudlik, Gyöngyi, Vas, Virág, Sipeki, Szabolcs, Cserkaszky, Anna, Radnai, László, Buday, László

“…The nonreceptor tyrosine kinase Src is a central component of the epidermal growth factor (EGF) signaling pathway. Our group recently showed that the Frank-ter…”
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Significance of the Tks4 scaffold protein in bone tissue homeostasis by Vas, Virag, Kovács, Tamás, Körmendi, Szandra, Bródy, Andrea, Kudlik, Gyöngyi, Szeder, Bálint, Mező, Diána, Kállai, Dóra, Koprivanacz, Kitti, Merő, Balázs L., Dülk, Metta, Tóvári, József, Vajdovich, Péter, Şenel, Ş. Neslihan, Özcan, Ilknur, Helyes, Zsuzsanna, Dobó-Nagy, Csaba, Buday, László

“…The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic…”
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Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin-GnRH-III conjugates developed for targeted drug delivery by Schuster, Sabine, Biri-Kovács, Beáta, Szeder, Bálint, Farkas, Viktor, Buday, László, Szabó, Zsuzsanna, Halmos, Gábor, Mező, Gábor

“…Gonadotropin releasing hormone-III (GnRH-III), a native isoform of the human GnRH isolated from sea lamprey, specifically binds to GnRH receptors on cancer…”
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Establishment and Characterization of a Brca1 -/- , p53 -/- Mouse Mammary Tumor Cell Line by Hámori, Lilla, Kudlik, Gyöngyi, Szebényi, Kornélia, Kucsma, Nóra, Szeder, Bálint, Póti, Ádám, Uher, Ferenc, Várady, György, Szüts, Dávid, Tóvári, József, Füredi, András, Szakács, Gergely

“…Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer…”
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Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding by Szabó, Beáta, Murvai, Nikoletta, Abukhairan, Rawan, Schád, Éva, Kardos, József, Szeder, Bálint, Buday, László, Tantos, Ágnes

“…Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular processes and are extensively involved in the development of different cancers;…”
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Drug Conjugation Induced Modulation of Structural and Membrane Interaction Features of Cationic Cell-Permeable Peptides by Pári, Edit, Horváti, Kata, Bősze, Szilvia, Biri-Kovács, Beáta, Szeder, Bálint, Zsila, Ferenc, Kiss, Éva

“…Cell-penetrating peptides might have great potential for enhancing the therapeutic effect of drug molecules against such dangerous pathogens as (Mtb), which…”
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Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4 by Merő, Balázs, Koprivanacz, Kitti, Cserkaszky, Anna, Radnai, László, Vas, Virag, Kudlik, Gyöngyi, Gógl, Gergő, Sok, Péter, Póti, Ádám L., Szeder, Bálint, Nyitray, László, Reményi, Attila, Geiszt, Miklós, Buday, László

“…The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation…”
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In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery by Tripodi, Andrea Angelo Pierluigi, Ranđelović, Ivan, Biri-Kovács, Beáta, Szeder, Bálint, Mező, Gábor, Tóvári, József

“…Among various homing devices, peptides containing the NGR tripeptide sequence represent a promising approach to selectively recognize CD13 receptor isoforms on…”
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Dynamic control of RSK complexes by phosphoswitch‐based regulation by Gógl, Gergő, Biri‐Kovács, Beáta, Póti, Ádám L., Vadászi, Henrietta, Szeder, Bálint, Bodor, Andrea, Schlosser, Gitta, Ács, András, Turiák, Lilla, Buday, László, Alexa, Anita, Nyitray, László, Reményi, Attila

“…Assembly and disassembly of protein–protein complexes needs to be dynamically controlled and phosphoswitches based on linear motifs are crucial in this…”
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Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification by Schuster, Sabine, Biri-Kovács, Beáta, Szeder, Bálint, Buday, László, Gardi, János, Szabó, Zsuzsanna, Halmos, Gábor, Mező, Gábor

“…Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and…”
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Structure-Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy by Biri-Kovács, Beáta, Adorján, Afrodité, Szabó, Ildikó, Szeder, Bálint, Bősze, Szilvia, Mező, Gábor

“…Human epidermal growth factor (HER2) is a transmembrane tyrosine kinase receptor that is frequently overexpressed in breast cancer. Its increased level…”
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Structural insights into the tyrosine phosphorylation–mediated inhibition of SH3 domain–ligand interactions by Merő, Balázs, Radnai, László, Gógl, Gergő, Tőke, Orsolya, Leveles, Ibolya, Koprivanacz, Kitti, Szeder, Bálint, Dülk, Metta, Kudlik, Gyöngyi, Vas, Virág, Cserkaszky, Anna, Sipeki, Szabolcs, Nyitray, László, Vértessy, Beáta G., Buday, László

“…Src homology 3 (SH3) domains bind proline-rich linear motifs in eukaryotes. By mediating inter- and intramolecular interactions, they regulate the functions of…”
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Tailoring Uptake Efficacy of HSV-1 gD Tailoring Uptake Efficacy of Hsv-1 GD Derived Carrier Peptides by Bősze, Szilvia, Zsila, Ferenc, Biri-Kovács, Beáta, Szeder, Bálint, Majer, Zsuzsa, Hudecz, Ferenc, Uray, Katalin

“…Regions of the Herpes simplex virus-1 (HSV-1) glycoprotein D (gD) were chosen to design carrier peptides based on the known tertiary structure of the virus…”
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Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37 by Quemé-Peña, Mayra, Ricci, Maria, Juhász, Tünde, Horváti, Kata, Bősze, Szilvia, Biri-Kovács, Beáta, Szeder, Bálint, Zsila, Ferenc, Beke-Somfai, Tamás

“…The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic activity ranging from immunological to anti-neoplastic functions…”
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Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells by Szeder, Bálint, Tárnoki-Zách, Júlia, Lakatos, Dóra, Vas, Virág, Kudlik, Gyöngyi, Merő, Balázs, Koprivanacz, Kitti, Bányai, László, Hámori, Lilla, Róna, Gergely, Czirók, András, Füredi, András, Buday, And László

“…Epithelial to mesenchymal transition (EMT) is a multipurpose process involved in wound healing, development, and certain pathological processes, such as…”
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Modification of Short Non‐Permeable Peptides to Increase Cellular Uptake and Cytostatic Activity of Their Conjugates by Yousef, Mo'ath, Szabó, Ildikó, Biri‐Kovács, Beáta, Szeder, Bálint, Illien, Françoise, Sagan, Sandrine, Bánóczi, Zoltán

“…Cell‐penetrating peptides (CPPs) are well‐known delivery vectors, oligoarginines are an important class of CPPs, which was modified to increase the cellular…”
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The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages by Dülk, Metta, Kudlik, Gyöngyi, Fekete, Anna, Ernszt, Dávid, Kvell, Krisztián, Pongrácz, Judit E., Merő, Balázs L., Szeder, Bálint, Radnai, László, Geiszt, Miklós, Csécsy, Dalma E., Kovács, Tamás, Uher, Ferenc, Lányi, Árpád, Vas, Virag, Buday, László

“…The commitment steps of mesenchymal stromal cells (MSCs) to adipogenic and other lineages have been widely studied but not fully understood. Therefore, it is…”
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