Search Results - "Sze, Christie C"

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism by Wang, Lu, Collings, Clayton K, Zhao, Zibo, Cozzolino, Kira Alia, Ma, Quanhong, Liang, Kaiwei, Marshall, Stacy A, Sze, Christie C, Hashizume, Rintaro, Savas, Jeffrey Nicholas, Shilatifard, Ali

“…Mutations and translocations within the COMPASS (complex of proteins associated with Set1) family of histone lysine methyltransferases are associated with a…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer by Sze, Christie C., Shilatifard, Ali

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SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression by Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Morgan, Marc A, Rendleman, Emily J, Wang, Lu, Sze, Christie C, Sun, Tianjiao, Bartom, Elizabeth T, Shilatifard, Ali

“…The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation by Morgan, Marc A J, Rickels, Ryan A, Collings, Clayton K, He, Xiaolin, Cao, Kaixiang, Herz, Hans-Martin, Cozzolino, Kira A, Abshiru, Nebiyu A, Marshall, Stacy A, Rendleman, Emily J, Sze, Christie C, Piunti, Andrea, Kelleher, Neil L, Savas, Jeffrey N, Shilatifard, Ali

“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family by Sze, Christie C, Ozark, Patrick A, Cao, Kaixiang, Ugarenko, Michal, Das, Siddhartha, Wang, Lu, Marshall, Stacy A, Rendleman, Emily J, Ryan, Caila A, Zha, Didi, Douillet, Delphine, Chen, Fei Xavier, Shilatifard, Ali

“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer by Sze, Christie C, Shilatifard, Ali

“…During development, precise spatiotemporal patterns of gene expression are coordinately controlled by cis-regulatory modules known as enhancers. Their crucial…”
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A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells by Cenik, Bercin K, Sze, Christie C, Ryan, Caila A, Das, Siddhartha, Cao, Kaixiang, Douillet, Delphine, Rendleman, Emily J, Zha, Didi, Khan, Nabiha Haleema, Bartom, Elizabeth, Shilatifard, Ali

“…Embryonic stem cells (ESCs) are defined by their ability to self-renew and the potential to differentiate into all tissues of the developing organism. We…”
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Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy by Miller, Nimrod, Feng, Zhihua, Edens, Brittany M, Yang, Ben, Shi, Han, Sze, Christie C, Hong, Benjamin Taige, Su, Susan C, Cantu, Jorge A, Topczewski, Jacek, Crawford, Thomas O, Ko, Chien-Ping, Sumner, Charlotte J, Ma, Long, Ma, Yong-Chao

“…Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many…”
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Developmental coupling of larval and adult stages in a complex life cycle: insights from limb regeneration in the flour beetle, Tribolium castaneum by Lee, Alison K, Sze, Christie C, Kim, Elaine R, Suzuki, Yuichiro

“…A complex life cycle, such as complete metamorphosis, is a key innovation that can promote diversification of species. The evolution of a morphologically…”
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The COMPASS Family of Histone H3 Lysine 4 Methyltransferases in Transcriptional Regulation, Stem Cell Pluripotency, and Development by Sze, Christie C

“…The evolutionarily conserved COMPASS family of methyltransferases implements histone H3 lysine 4 (H3K4) methylation, an epigenetic mark associated with…”
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