Growth performance, selected blood biochemical parameters and body weights of pre-pubertal gilts fed diets supplemented with different doses of zearalenone (ZEN)

Growth performance, selected blood biochemical parameters and body weights of pre-pubertal gilts fed diets supplemented with different doses of zearalenone (ZEN)

The aim of this study was to determine whether exposure to low doses of zearalenone (ZEN) induces changes in the serum biochemical profile and body weights (BW). Pre-pubertal gilts (with BW of up to 14.5 kg) were administered ZEN in daily doses of 5 μg/kg BW (group 1, n = 15), 10 μg/kg BW (group 2,...

Full description

Saved in:
Bibliographic Details
Published in:Toxicon (Oxford) Vol. 152; pp. 84 - 94
Main Authors: Rykaczewska, Anna, Gajęcka, Magdalena, Dąbrowski, Michał, Wiśniewska, Anita, Szcześniewska, Justyna, Gajęcki, Maciej T., Zielonka, Łukasz
Format: Journal Article
Language:English
Published: England Elsevier Ltd 15-09-2018
Subjects:
Animal Feed - analysis
Animals
Biotransformation
Blood biochemistry
Body weight
Body Weight - drug effects
Diet - veterinary
Female
Food Contamination
Low doses
Pre-pubertal gilts
Swine - blood
Zearalenone
Zearalenone - administration & dosage
Zearalenone - metabolism
Zearalenone - toxicity
CONTAM Panel
UV
AST
DON
ZEN
Low doses
ALP
Body weight
Zearalenone
Pre-pubertal gilts
ALT
MABEL
EFSA
SD
Blood biochemistry
Pin
BW
LOAEL
NOAEL
PLT
BUN
HPLC
Fe
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to determine whether exposure to low doses of zearalenone (ZEN) induces changes in the serum biochemical profile and body weights (BW). Pre-pubertal gilts (with BW of up to 14.5 kg) were administered ZEN in daily doses of 5 μg/kg BW (group 1, n = 15), 10 μg/kg BW (group 2, n = 15), 15 μg/kg BW (group 3, n = 15) or placebo (control group C, n = 15) throughout the experiment. Blood was sampled for analysis on 10 dates (at five-day intervals). Minor but statistically significant differences in the analysed serum biochemical parameters (ALT, AST, ALP, total cholesterol, total bilirubin, glucose, total protein, iron, BUN and urea) were observed in the studied groups. The biochemical parameters of the analysed gilts indicate that the maintenance of homeostasis and biotransformation of ZEN require considerable energy expenditure. Beginning on the fourth analytical date, BW gains were consistently higher in the experimental groups than in group C. The observed decrease in glucose and total protein levels can probably be attributed to higher BW gains and the ongoing ZEN biotransformation processes in the enterocytes and the liver. •Exposure to low doses of ZEN induces a decrease in glucose and total protein levels, which contributes to weight gains.•Low ZEN doses induce adaptive and/or compensatory mechanisms in pre-pubertal gilts.•Low doses of ZEN (MABEL, NOAEL and LOAEL) can exert a stimulatory effect on pre-pubertal gilts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2018.07.013