Search Results - "Szarfman, A"

Qualification of cardiac troponins for nonclinical use: A regulatory perspective by Hausner, E.A., Hicks, K.A., Leighton, J.K., Szarfman, A., Thompson, A.M., Harlow, P.

“…•Discussion of first successful use of published research for biomarker qualification.•The cardiac troponins submission and proposed context of use are…”
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Data mining clinical records to detect adverse events by Coster, T. S., Szarfman, A., Fram, D., Russell, C.

“…Background Longitudinal clinical data can provide new insights regarding the safety of drugs through the application of data mining. The objective of our…”
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Characterization of Plasmodium falciparum Sporozoite Surface Protein 2 by Rogers, William O., Malik, Anita, Mellouk, Sylvie, Nakamura, Kenichiro, Rogers, Miriam D., Szarfman, Ana, Gordon, Daniel M., Nussler, Andreas K., Aikawa, Masamichi, Hoffman, Stephen L.

“…Immunization of mice with Plasmodium yoelii sporozoite surface protein 2 (PySSP2) and circumsporozoite protein protects completely against P. yoelii. The amino…”
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Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA's spontaneous reports database by SZARFMAN, Ana, MACHADO, Stella G, O'NEILL, Robert T

“…Since 1998, the US Food and Drug Administration (FDA) has been exploring new automated and rapid Bayesian data mining techniques. These techniques have been…”
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Bayesian Data Mining in Large Frequency Tables, with an Application to the FDA Spontaneous Reporting System by Dumouchel, William

“…A common data mining task is the search for associations in large databases. Here we consider the search for "interestingly large" counts in a large frequency…”
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Antibodies to laminin in Chagas' disease by Szarfman, A, Terranova, V.P, Rennard, S.I, Foidart, J.M, Lima, M.F

“…Trypanosoma cruzi, patients with Chagas' disease, rhesus monkeys, sera contain antilaminin antibodies, significance of antilaminin antibodies to pathology is…”
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Perspectives on the use of data mining in pharmacovigilance by ALMENOFF, June, TONNING, Joseph M, SACKS, Susan T, YUEN, Nancy, PATADIA, Vaishali, BLUM, Michael, JOHNSTON, Mike, GERRITS, Charles, SEIFERT, Harry, LACROIX, Karol, LAWRENCE GOUID, A, SZARFMAN, Ana, HAUBEN, Manfred, OUELLET-HELLSTROM, Rita, BALL, Robert, HORNBUCKLE, Ken, WALSH, Louisa, YEE, Chuen

“…In the last 5 years, regulatory agencies and drug monitoring centres have been developing computerised data-mining methods to better identify reporting…”
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An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system by Colman, Eric, Szarfman, Ana, Wyeth, Jo, Mosholder, Andrew, Jillapalli, Devanand, Levine, Jonathan, Avigan, Mark

“…Background We detected disproportionate reporting of amyotrophic lateral sclerosis (ALS) with HMG‐CoA‐reductase inhibitors (statins) in the Food and Drug…”
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Pharmacovigilance in the 21st Century: New Systematic Tools for an Old Problem by Szarfman, Ana, Tonning, Joseph M., Doraiswamy, P. Murali

“…The large number of adverse‐event reports generated by marketed drugs and devices argues for the application of validated computerized algorithms to supplement…”
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Data mining analysis of psychosis with mefloquine and other antimalarial drugs by Coster, T. S., Szarfman, A.

“…Purpose Mefloquine is used for treatment and prophylaxis of chloroquine‐resistant malaria. In 2003, thirteen years after its introduction into the US market,…”
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Antibody-induced capping of the intracellular stage of Trypanosoma cruzi by Leon, W, Villalta, F, Queiroz, T, Szarfman, A

“…Article Usage Stats Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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T lymphocytes from mice immunized with irradiated sporozoites eliminate malaria from hepatocytes by Hoffman, S L, Isenbarger, D, Long, G W, Sedegah, M, Szarfman, A, Mellouk, S, Ballou, W R

“…When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown…”
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Effect of malaria chemoprophylaxis on the development of antibodies to Plasmodium falciparum in expatriates living in west Africa by Philpott, J, Keystone, J S, Reid, A, Chulay, J D, Wirtz, R A, Szarfman, A

“…We studied the relationship between exposure to malaria, the use of long-term chemoprophylaxis with chloroquine, and the prevalence of sporozoite antibodies in…”
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Circulating antibodies to peripheral nerve in American trypanosomiasis (Chagas' disease) by Khoury, E L, Ritacco, V, Cossio, P M, Laguens, R P, Szarfman, A, Diez, C, Arana, R M

“…An antibody reacting with Schwann sheaths of myelinated somatic and unmyelinated autonomic peripheral nerve was found in sixty-one out of seventy-one chronic,…”
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Induction of capping in blood-stage trypomastigotes of Trypanosoma cruzi by human anti-Trypanosoma cruzi antibodies by G A Schmuñis, A Szarfman, T Langembach, W de Souza

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures by Cossio, P M, Diez, C, Szarfman, A, Kreutzer, E, Candiolo, B, Arana, R M

“…Twenty-four out of 25 patients with Chagas' heart disease have circulating immunoglobulins which react by indirect immunofluorescence technique with…”
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Reply: The evaluation of data mining methods for the simultaneous and systematic detection of safety signals in large databases: lessons to be learned by Levine, Jonathan G., Tonning, Joseph M., Szarfman, Ana

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Evaluation of a synthetic oligonucleotide probe for diagnosis of Plasmodium falciparum infections by Mucenski, C M, Guerry, P, Buesing, M, Szarfman, A, Trosper, J, Walliker, D, Watt, G, Sangalang, R, Ranoa, C P, Tuazon, M

“…A radiolabeled synthetic oligonucleotide was evaluated as a diagnostic probe specific for Plasmodium falciparum using blood samples lysed directly on…”
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Chagasic cardiopathy. Antibodies reacting with plasma membrane of striated muscle and endothelial cells by Cossio, P M, Laguens, R P, Diez, C, Szarfman, A, Segal, A, Arana, R M

“…An antibody reacting with endocardium, vascular structures and interstitium of striated muscle (EVI antibody), by the indirect immunofluorescence technique,…”
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Absence of left ventricular dysfunction during acute chagasic myocarditis in the rhesus monkey by LIMA, J. A. C, SZARFMAN, A, LIMA, S. D, ADAMS, R. J, RUSSELL, R. J, CHEEVER, A, TRISCHMANN, T, WEISS, J. L

“…Recent studies suggest that intracellular Trypanosoma cruzi invasion with release of intracellular myocardial antigens during T. cruzi infection is crucial to…”
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