Search Results - "Szal, Teresa"

Engineered ribosomes with tethered subunits for expanding biological function by Carlson, Erik D., d’Aquino, Anne E., Kim, Do Soon, Fulk, Emily M., Hoang, Kim, Szal, Teresa, Mankin, Alexander S., Jewett, Michael C.

“…Ribo-T is a ribosome with covalently tethered subunits where core 16S and 23S ribosomal RNAs form a single chimeric molecule. Ribo-T makes possible a…”
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A fully orthogonal system for protein synthesis in bacterial cells by Aleksashin, Nikolay A., Szal, Teresa, d’Aquino, Anne E., Jewett, Michael C., Vázquez-Laslop, Nora, Mankin, Alexander S.

“…Ribosome engineering is a powerful approach for expanding the catalytic potential of the protein synthesis apparatus. Due to the potential detriment the…”
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Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics by Tsai, Kaitlyn, Stojković, Vanja, Lee, D. John, Young, Iris D., Szal, Teresa, Klepacki, Dorota, Vázquez-Laslop, Nora, Mankin, Alexander S., Fraser, James S., Fujimori, Danica Galonić

“…The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the…”
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Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly by Huang, Shijie, Aleksashin, Nikolay A., Loveland, Anna B., Klepacki, Dorota, Reier, Kaspar, Kefi, Amira, Szal, Teresa, Remme, Jaanus, Jaeger, Luc, Vázquez-Laslop, Nora, Korostelev, Andrei A., Mankin, Alexander S.

“…5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an…”
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The Genetic Environment of the cfr Gene and the Presence of Other Mechanisms Account for the Very High Linezolid Resistance of Staphylococcus epidermidis Isolate 426-3147L by LAMARRE, Jacqueline, MENDES, Rodrigo E, SZAL, Teresa, SCHWARZ, Stefan, JONES, Ronald N, MANKIN, Alexander S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis by Schulze, Christopher J, Bray, Walter M, Loganzo, Frank, Lam, My-Hanh, Szal, Teresa, Villalobos, Anabella, Koehn, Frank E, Linington, Roger G

“…Borrelidin (1) is a nitrile-containing bacterially derived polyketide that is a potent inhibitor of bacterial and eukaryotic threonyl-tRNA synthetases. We now…”
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Protein synthesis by ribosomes with tethered subunits by Orelle, Cédric, Carlson, Erik D., Szal, Teresa, Florin, Tanja, Jewett, Michael C., Mankin, Alexander S.

“…A ribosome with tethered subunits, ‘Ribo-T’, is engineered by making a hybrid RNA composed of ribosomal RNA of large and small subunits; Ribo-T can support…”
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Charting the sequence-activity landscape of peptide inhibitors of translation termination by Baliga, Chetana, Brown, Tyler J., Florin, Tanja, Colon, Sarah, Shah, Vallari, Skowron, Kornelia J., Kefi, Amira, Szal, Teresa, Klepacki, Dorota, Moore, Terry W., Vázquez-Laslop, Nora, Mankin, Alexander S.

“…Apidaecin (Api), an unmodified 18-amino-acid-long proline-rich antibacterial peptide produced by bees, has been recently described as a specific inhibitor of…”
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Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition by Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J, Vázquez-Laslop, Nora, Mankin, Alexander S

“…Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery…”
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Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome by Polikanov, Yury S., Osterman, Ilya A., Szal, Teresa, Tashlitsky, Vadim N., Serebryakova, Marina V., Kusochek, Pavel, Bulkley, David, Malanicheva, Irina A., Efimenko, Tatyana A., Efremenkova, Olga V., Konevega, Andrey L., Shaw, Karen J., Bogdanov, Alexey A., Rodnina, Marina V., Dontsova, Olga A., Mankin, Alexander S., Steitz, Thomas A., Sergiev, Petr V.

“…We demonstrate that the antibiotic amicoumacin A (AMI) is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the…”
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Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA by Polikanov, Yury S., Szal, Teresa, Jiang, Fuyan, Gupta, Pulkit, Matsuda, Ryoichi, Shiozuka, Masataka, Steitz, Thomas A., Vázquez-Laslop, Nora, Mankin, Alexander S.

“…Negamycin (NEG) is a ribosome-targeting antibiotic that exhibits clinically promising activity. Its binding site and mode of action have remained unknown. We…”
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