Search Results - "Szak, Suzanne"

BIN1 favors the spreading of Tau via extracellular vesicles by Crotti, Andrea, Sait, Hameetha Rajamohamend, McAvoy, Kathleen M., Estrada, Karol, Ergun, Ayla, Szak, Suzanne, Marsh, Galina, Jandreski, Luke, Peterson, Michael, Reynolds, Taylor L., Dalkilic-Liddle, Isin, Cameron, Andrew, Cahir-McFarland, Ellen, Ransohoff, Richard M.

“…Despite Bridging INtegrator 1 ( BIN1 ) being the second most statistically-significant locus associated to Late Onset Alzheimer’s Disease, its role in disease…”
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Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes by Boeke, Jef D, Han, Jeffrey S, Szak, Suzanne T

“…LINE-1 (L1) elements are the most abundant autonomous retrotransposons in the human genome, accounting for about 17% of human DNA. The L1 retrotransposon…”
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Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring by Calabresi, Peter A, Arnold, Douglas L, Sangurdekar, Dipen, Singh, Carol M, Altincatal, Arman, de Moor, Carl, Engle, Bob, Goyal, Jaya, Deykin, Aaron, Szak, Suzanne, Kieseier, Bernd C, Rudick, Richard A, Plavina, Tatiana

“…Objective: To understand how longitudinal serum neurofilament light chain (sNfL) patterns can inform its use as a prognostic biomarker in multiple sclerosis…”
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Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis by Nakagawa, Naoki, Xin, Cuiyan, Roach, Allie M, Naiman, Natalie, Shankland, Stuart J, Ligresti, Giovanni, Ren, Shuyu, Szak, Suzanne, Gomez, Ivan G, Duffield, Jeremy S

“…MicroRNAs, activated by the enzyme Dicer1, control post-transcriptional gene expression. Dicer1 has important roles in the epithelium during nephrogenesis, but…”
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TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease by Gomez, Ivan G, Roach, Allie M, Nakagawa, Naoki, Amatucci, Aldo, Johnson, Bryce G, Dunn, Kadeshia, Kelly, Mark C, Karaca, Gamze, Zheng, Timothy S, Szak, Suzanne, Peppiatt-Wildman, Claire M, Burkly, Linda C, Duffield, Jeremy S

“…The identification of the cellular origins of myofibroblasts has led to the discovery of novel pathways that potentially drive myofibroblast perpetuation in…”
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Molecular archeology of L1 insertions in the human genome by Szak, Suzanne T, Pickeral, Oxana K, Makalowski, Wojciech, Boguski, Mark S, Landsman, David, Boeke, Jef D

“…As the rough draft of the human genome sequence nears a finished product and other genome-sequencing projects accumulate sequence data exponentially,…”
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Human L1 Retrotransposition Is Associated with Genetic Instability In Vivo by Symer, David E., Connelly, Carla, Szak, Suzanne T., Caputo, Emerita M., Cost, Gregory J., Parmigiani, Giovanni, Boeke, Jef D.

“…Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic…”
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Kinetics of p53 Binding to Promoter Sites In Vivo by Szak, Suzanne T., Mays, Deborah, Pietenpol, Jennifer A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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p53 Regulation of G2 Checkpoint Is Retinoblastoma Protein Dependent by Flatt, Patricia M., Tang, Luo Jia, Scatena, Caroline D., Szak, Suzanne T., Pietenpol, Jennifer A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Arthritogenic Simulation of Human Synovial Fibroblasts by TWEAK by Zheng, Timothy, Senior Scientist, Biogen Idec, Inc., Cambridge, MA, Weng, Shawn, Associate Scientist, Biogen Idec, Inc., Cambridge, MA, Szak, Suzanne, Scientist II, Biogen Idec, Inc., Cambridge, MA, Burkly, Linda, Distinguished Investigator, Biogen Idec, Inc., Cambridge, MA

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Identifying related L1 retrotransposons by analyzing 3' transduced sequences by Szak, Suzanne T, Pickeral, Oxana K, Landsman, David, Boeke, Jef D

“…A large fraction of the human genome is attributable to L1 retrotransposon sequences. Not only do L1s themselves make up a significant portion of the genome,…”
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Associations of Serum Neurofilament Light Chain with Clinico-Radiological Characteristics in the MSPATHS Network: A Cross-Sectional Evaluation (1722) by Sotirchos, Elias, Fitzgerald, Kathryn, Smith, Matthew, Williams, James, de Moor, Carl, Szak, Suzanne, Singh, Carol, Fisher, Elizabeth, Bermel, Robert, Hersh, Carrie, Hyland, Megan, Krupp, Lauren, Montalban, Xavier, Naismith, Robert, Nicholas, Jacqueline, Comabella, Manuel, Ziemssen, Tjalf, Mowry, Ellen, Calabresi, Peter

“…Abstract only…”
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The NRF2 transcriptional target, OSGIN1, contributes to the cytoprotective properties of monomethyl fumarate. (P1.150) by Brennan, Melanie, Matos, Maria, Sun, Chao, Szak, Suzanne, Scannevin, Robert

“…Abstract only…”
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ProbeSelect: selecting differentially expressed probes in transcriptional profile data by Hosur, Raghavendra, Szak, Suzanne, Thai, Alice, Allaire, Norm, Bienkowska, Jadwiga

“…Transcriptional profiling still remains one of the most popular techniques for identifying relevant biomarkers in patient samples. However, heterogeneity in…”
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Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury by Dang, Lan T.H., Aburatani, Takahide, Marsh, Graham A., Johnson, Bryce G., Alimperti, Stella, Yoon, Christine J., Huang, Angela, Szak, Suzanne, Nakagawa, Naoki, Gomez, Ivan, Ren, Shuyu, Read, Sarah K., Sparages, Chris, Aplin, Alfred C., Nicosia, Roberto F., Chen, Chris, Ligresti, Giovanni, Duffield, Jeremy S.

“…Loss of the microvascular (MV) network results in tissue ischemia, loss of tissue function, and is a hallmark of chronic diseases. The incorporation of a…”
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Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis by Kawashima, Rei, Kawamura, Yuki I, Oshio, Tomoyuki, Son, Aoi, Yamazaki, Motomi, Hagiwara, Teruki, Okada, Toshihiko, Inagaki–Ohara, Kyoko, Wu, Ping, Szak, Suzanne, Kawamura, Yutaka J, Konishi, Fumio, Miyake, Oki, Yano, Hideaki, Saito, Yukio, Burkly, Linda C, Dohi, Taeko

“…Background & Aims TWEAK, a member of the tumor necrosis factor (TNF) superfamily, promotes intestinal epithelial cell injury and signals through the receptor…”
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Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies by Ranger, Ann, Ray, Soma, Szak, Suzanne, Dearth, Andrea, Allaire, Norm, Murray, Ronald, Gardner, Rebecca, Cadavid, Diego, Mi, Sha

“…To evaluate whether the anti-LINGO-1 antibody has immunomodulatory effects. Human peripheral blood mononuclear cells (hPBMCs), rat splenocytes, and rat CD4 T…”
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Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts by Mullenbrock, Steven, Liu, Fei, Szak, Suzanne, Hronowski, Xiaoping, Gao, Benbo, Juhasz, Peter, Sun, Chao, Liu, Mei, McLaughlin, Helen, Xiao, Qiurong, Feghali-Bostwick, Carol, Zheng, Timothy S

“…Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular matrix (ECM) deposition and fibrosis progression in both…”
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Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines by Demarest, Stephen J, Gardner, Jennifer, Vendel, Michelle C, Ailor, Eric, Szak, Suzanne, Huang, Flora, Doern, Adam, Tan, Xiangyang, Yang, Weixing, Grueneberg, Dorre A, Richards, Edward J, Endege, Wilson O, Harlow, Ed, Koopman, Louise A

“…Tyro3, a member of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, has emerged as a potential oncogene in melanoma. Here, we confirm that Tyro3 is…”
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Blocking LINGO-1 Does Not Affect Inflammatory Markers in the Cerebrospinal Fluid of Individuals with Multiple Sclerosis (P1.186) by Ranger, Ann, Ray, Soma, Szak, Suzanne, Dearth, Andrea, Allaire, Normand, Cadavid, Diego

“…Abstract only…”
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